知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

13 条记录 (耗时 0.023 秒)

    Process for purifying an organic acid
    3.
    发明授权
    Process for purifying an organic acid 失效
    纯化有机酸的方法

    公开(公告)号：US06641734B2

    公开(公告)日：2003-11-04

    申请号：US10037664

    申请日：2002-01-03

    申请人： Michael Charles Milner Cockrem ,  Istvan Kovacs ,  Idris Mohamednur ,  David Heidel

    发明人： Michael Charles Milner Cockrem ,  Istvan Kovacs ,  Idris Mohamednur ,  David Heidel

    IPC分类号： B01D1100

    CPC分类号： C07C51/48 ,  C07C59/08

    摘要： A process is disclosed for purifying an aqueous feed stream comprising a product organic acid, such as lactic acid, and a strong contaminant, such as pyruvic acid or oxalic acid. The molar concentration of the product organic acid in the feed stream typically is at least 20 times greater than the molar concentration of the strong contaminant. The aqueous feed stream is contacted with a first immiscible basic extractant that has at least a 3-fold greater affinity for the strong contaminant than for the product organic acid. The majority of the strong contaminant and some product organic acid become complexed with the first immiscible basic extractant. The complexed first immiscible basic extractant is separated from the aqueous stream, thereby producing a first effluent stream that comprises product organic acid and that has a greater ratio of molar product organic acid to molar strong contaminant than the aqueous feed stream did. The complexed first immiscible basic extractant is contacted with a displacing acid. The first immiscible basic extractant has a greater affinity for the displacing acid than it does for the strong contaminant or the product organic acid, and as a result, product organic acid and strong contaminant are displaced over a period of time from the complexed first immiscible basic extractant, producing a second effluent stream that comprises a major amount of product organic acid and a third effluent stream that comprises a major amount of strong contaminant.

    摘要翻译： 公开了用于纯化包含产物有机酸如乳酸和强烈污染物如丙酮酸或草酸的含水进料流的方法。 进料流中产物有机酸的摩尔浓度通常比强污染物的摩尔浓度大至少20倍。 含水进料流与第一不混溶碱性萃取剂接触，对于强污染物的亲和力比产物有机酸具有至少3倍的亲和力。 大部分强烈的污染物和一些产品的有机酸与第一个不混溶的碱性萃取剂复合。 将复合的第一不混溶的碱性萃取剂与水流分离，从而产生包含产物有机酸的第一流出物流，并且与含水进料流具有更大的摩尔产物有机酸与摩尔强的污染物的比例。 复合的第一不混溶碱性萃取剂与置换酸接触。 第一种不混溶的碱性萃取剂对于排出酸的亲和力高于对强的污染物或产品有机酸的亲和性，结果产物有机酸和强的污染物在一段时间内从复合的第一不溶混碱 产生包含大量产物有机酸的第二流出物流和包含主要量的强污染物的第三流出物流。

    Process for production of esters
    4.
    发明授权
    Process for production of esters 失效
    酯类的生产工艺

    公开(公告)号：US06664413B1

    公开(公告)日：2003-12-16

    申请号：US09196266

    申请日：1998-11-19

    申请人： Michael Charles Milner Cockrem

    发明人： Michael Charles Milner Cockrem

    IPC分类号： C07C6736

    CPC分类号： C07C67/08 ,  C07C69/68

    摘要： A process for producing an ester comprises the steps of: (a) feeding to a first vessel a feed that comprises organic acid, alcohol, and water, whereby organic acid and alcohol react to form monomeric ester and water, and whereby a first liquid effluent is produced that comprises as its components at least some ester, alcohol, and water, the components of the first liquid effluent being substantially in reaction equilibrium; and (b) feeding the first liquid effluent to a second vessel, whereby a vapor product stream and a second liquid effluent stream are produced, the vapor stream comprising ester, alcohol, and water, wherein the second vessel is maintained substantially at vapor-liquid equilibrium but not substantially at reaction equilibrium.

    摘要翻译： 一种制备酯的方法包括以下步骤：（a）向第一容器供给包含有机酸，醇和水的进料，由此有机酸和醇反应形成单体酯和水，由此第一液体流出物 产生，其包含至少一些酯，醇和水作为其组分，第一液体流出物的组分基本上处于反应平衡状态; 和（b）将第一液体流出物供给到第二容器中，由此产生蒸气产物流和第二液体流出物流，所述蒸气流包含酯，醇和水，其中第二容器基本维持在气液 平衡但基本上不反应平衡。

    Azeotropic distillation of cyclic esters of hydroxy organic acids
    6.
    发明授权
    Azeotropic distillation of cyclic esters of hydroxy organic acids 失效
    共沸蒸馏羟基有机酸的环酯

    公开(公告)号：US06984293B2

    公开(公告)日：2006-01-10

    申请号：US09809534

    申请日：2001-03-15

    申请人： Michael Charles Milner Cockrem ,  Istvan Kovacs

    发明人： Michael Charles Milner Cockrem ,  Istvan Kovacs

    IPC分类号： C07D319/00 ,  B01D3/38

    CPC分类号： C07C51/46 ,  B01D3/36 ,  C07C51/42 ,  C07C59/06 ,  C07C59/08

    摘要： Cyclic esters of hydroxy organic acids can be produced and recovered via azeotropic distillation. In certain embodiments cyclic esters, such as glycolide and lactide, can be produced from a fermentation broth or other feed stream that contains a hydroxy organic acid, an ammonium salt of a hydroxy organic acid, an amide of a hydroxy organic acid, or an ester of a hydroxy organic acid using azeotropic distillation. The hydroxy organic acid of the feed stream or the hydroxy organic acid derived from the feed stream by decomposition is reacted to produce the cyclic ester. In other embodiments a crude composition of a cyclic ester of an organic ester can be purified using azeotropic distillation.

    摘要翻译： 羟基有机酸的环状酯可以通过共沸蒸馏生产和回收。 在某些实施方案中，环状酯如乙交酯和丙交酯可以由发酵液或其它进料流生产，所述发酵液或其它进料流含有羟基有机酸，羟基有机酸的铵盐，羟基有机酸的酰胺或酯 的使用共沸蒸馏的羟基有机酸。 进料流的羟基有机酸或通过分解得自进料流的羟基有机酸反应生成环状酯。 在其它实施方案中，可以使用共沸蒸馏纯化有机酯的环状酯的粗组合物。

    Process for obtaining an organic acid from an organic acid ammonium salt, an organic acid amide, or an alkylamine organic acid complex
    7.
    发明授权
    Process for obtaining an organic acid from an organic acid ammonium salt, an organic acid amide, or an alkylamine organic acid complex 失效
    从有机酸铵盐，有机酸酰胺或烷基胺有机酸络合物中获得有机酸的方法

    公开(公告)号：US06926810B2

    公开(公告)日：2005-08-09

    申请号：US09809243

    申请日：2001-03-15

    申请人： Michael Charles Milner Cockrem ,  Istvan Kovacs

    发明人： Michael Charles Milner Cockrem ,  Istvan Kovacs

    IPC分类号： B01D3/36 ,  C07C51/02 ,  C07C51/06 ,  C07C51/46 ,  C07C231/24 ,  C07C235/06 ,  B01D3/10 ,  B01D3/14 ,  C07C51/48

    CPC分类号： C07C235/06 ,  B01D3/36 ,  C07C51/02 ,  C07C51/06 ,  C07C51/46 ,  C07C231/24 ,  Y10S516/07 ,  C07C59/08

    摘要： Disclosed herein are methods for the recovery of an organic acid, such as a heat stable lactic acid, from a feed stream which contains at least one of an organic acid amide, an organic acid ammonium salt, or an alkylamine-organic acid complex. The feed stream is mixed with at least one azeotroping agent. The azeotroping agent is a hydrocarbon capable of forming at least one azeotrope with the organic acid that is produced by the thermal decomposition of the amide, ammonium salt, or complex in the feed stream. Preferably the azeotrope is a heteroazeotrope. The mixture of the feed stream and the azeotroping agent is heated to produce a vapor stream. The azeotrope is a component of the vapor stream. The vapor stream can be condensed to a liquid stream, and the organic acid is recovered in the liquid stream that is produced. When the azeotrope is a heteroazeotrope, the vapor stream can be condensed into a liquid stream, which can be separated into a first phase and a second phase. The first phase contains the highest concentration of organic acid and the second phase contains azeotroping agent. The organic acid can be further purified and/or concentrated from the separated first phase or from the liquid stream.

    摘要翻译： 本文公开了从含有有机酸酰胺，有机酸铵盐或烷基胺 - 有机酸络合物中的至少一种的进料流中回收有机酸如热稳定性乳酸的方法。 进料流与至少一种共沸剂混合。 共沸剂是能够与通过进料流中的酰胺，铵盐或络合物的热分解产生的有机酸形成至少一种共沸物的烃。 共沸物优选为杂光子。 将进料流和共沸剂的混合物加热以产生蒸气流。 共沸物是蒸气流的一个组成部分。 蒸气流可以冷凝成液体流，有机酸在所生产的液体流中回收。 当共沸物是杂合物时，蒸汽流可以冷凝成液体流，其可以分离成第一相和第二相。 第一相含有最高浓度的有机酸，第二相含有共沸剂。 有机酸可以从分离的第一相或液体流进一步纯化和/或浓缩。

    Process for production of organic acids and esters thereof
    8.
    发明授权
    Process for production of organic acids and esters thereof 失效
    生产有机酸及其酯的方法

    公开(公告)号：US06291708B1

    公开(公告)日：2001-09-18

    申请号：US09301466

    申请日：1999-04-28

    申请人： Michael Charles Milner Cockrem

    发明人： Michael Charles Milner Cockrem

    IPC分类号： C07C5908

    CPC分类号： C07C51/42 ,  C07C51/412 ,  C07C67/08 ,  C07C59/08 ,  C07C69/68

    摘要： A process is disclosed for producing an organic acid and optionally for simultaneously producing an ester of the organic acid. The process comprises the steps of: (a) combining an aqueous diluent, an ammonium salt of an organic acid, and an alcohol, thereby forming a homogeneous liquid feed mixture; (b) rapidly heating the feed mixture at a pressure sufficient to suppress at least some vaporization of the alcohol and holding it at a temperature and for a time sufficient to decompose the ammonium salt of the organic acid into ammonia and free organic acid while rapidly removing the ammonia from the reaction-mass transfer equipment, and optionally to react at least some of the free organic acid with the alcohol to form an ester of the organic acid, thereby producing (i) a vapor product stream that comprises ammonia, water, and alcohol, and (ii) a liquid product stream that comprises free organic acid, optionally ester, and alcohol, where of the total quantity of alcohol in the vapor product stream and the liquid product stream, at least about 10% by weight is present in the liquid product stream; and (c) recovering the free organic acid and optionally the ester from the liquid product stream. The liquid feed mixture can comprise a concentrated crude or partially purified broth produced by a fermentation process.

    摘要翻译： 公开了一种用于生产有机酸和任选地同时生产有机酸酯的方法。 该方法包括以下步骤：（a）将水性稀释剂，有机酸的铵盐和醇组合，从而形成均匀的液体进料混合物; （b）以足以抑制醇的至少一些蒸发并将其保持在足以将有机酸的铵盐分解成氨和游离有机酸的温度和时间的温度快速加热进料混合物，同时快速除去 来自反应 - 传质设备的氨，并且任选地使至少一些游离有机酸与醇反应以形成有机酸的酯，从而产生（i）包含氨，水和 醇，和（ii）液体产物流，其包含游离有机酸，任选的酯和醇，其中蒸气产物流和液体产物流中的醇的总量至少约10重量％存在于 液体产品流; 和（c）从液体产物流中回收游离的有机酸和任选的酯。 液体进料混合物可以包含通过发酵过程产生的浓缩的粗制或部分纯化的肉汤。