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公开(公告)号：US20230099074A1
公开(公告)日：2023-03-30
申请号：US18049711
申请日：2022-10-26
发明人： Philip E. Brandish , Robert M. Garbaccio , Jeffrey Kern , Linda Liang , Sanjiv Shah , Dennis Zaller , Andrew Beck , Dennis Gately , Nick Knudsen , Anthony Manibusan , Jianing Wang , Ying Sun
摘要： Antibody drug conjugates (ADCs) comprising an antibody conjugated to an anti-inflammatory therapeutic agent via a phosphate-based linker with tunable extracellular and intracellular stability are described.
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公开(公告)号：US20230333090A1
公开(公告)日：2023-10-19
申请号：US17786039
申请日：2020-12-16
发明人： Kevin B. Gurney , Yue Zhang , Linda Liang , Cuiwei Ai
IPC分类号： G01N33/50 , C12N5/0783
CPC分类号： G01N33/505 , C12N5/0636 , G01N33/5023 , G01N2333/55 , G01N2333/70503
摘要： The present disclosure describes a murine T cell 3A9 comprising a polynucleotide sequence encoding human LAG3, and a murine IL-2 promotor operably associated with a reporter gene. The disclosure also describes a cell-based potency assay for measuring LAG3 antagonist activity using a co-cultured system with the murine T cells and LK35.2 murine B cells, and hen egg lysozyme peptide.
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公开(公告)号：US12102680B2
公开(公告)日：2024-10-01
申请号：US16806658
申请日：2020-05-15
发明人： Sybil M. G. Williams , Drake LaFace , Laurence Fayadat-Dilman , Gopalan Raghunathan , Linda Liang , Wolfgang Seghezzi
IPC分类号： A61K39/395 , A61K45/06 , C07K16/28 , A61K39/00
CPC分类号： A61K39/39541 , A61K39/3955 , A61K45/06 , C07K16/28 , C07K16/2803 , C07K16/2818 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to anti-TIGIT antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease.
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公开(公告)号：US11958902B2
公开(公告)日：2024-04-16
申请号：US16939883
申请日：2020-07-27
发明人： Sybil M. G. Williams , Wolfgang Seghezzi , Laurence Fayadat-Dilman , Linda Liang , Veronica Juan
IPC分类号： C07K16/28 , A61K39/395 , A61P31/00 , A61K39/00
CPC分类号： C07K16/2803 , A61K39/3955 , A61K39/39558 , A61K39/39566 , A61P31/00 , A61K2039/572 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention relates to anti-TIGIT antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease.
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公开(公告)号：US12102681B2
公开(公告)日：2024-10-01
申请号：US17669891
申请日：2022-02-11
IPC分类号： A61K39/395 , A61K45/06 , C07K16/28 , A61K39/00
CPC分类号： A61K39/39566 , A61K39/395 , A61K45/06 , C07K16/2803 , C07K16/2818 , C07K16/2896 , A61K2039/505 , A61K2039/507 , C07K2317/24 , C07K2317/32 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/50 , C07K2317/76 , C07K2317/92
摘要： The present invention includes antibodies and antigen-binding fragments thereof that specifically bind to human or cynomolgous monkey LAG3 as well as immunoglobulin chains thereof and polynucleotides encoding the same along with injection devices comprising such antibodies or fragments. Vaccines including such antibodies and fragments as well as compositions comprising the antibodies and fragments (e.g., including anti-PD1 antibodies) are included in the invention. Methods for treating or preventing cancer or infection using such compositions are also provided. In addition, methods for recombinant expression of the antibodies and fragments are part of the present invention.
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公开(公告)号：US11510993B2
公开(公告)日：2022-11-29
申请号：US15765515
申请日：2016-09-30
发明人： Philip E. Brandish , Robert M. Garbaccio , Jeffrey Kern , Linda Liang , Sanjiv Shah , Dennis Zaller , Andrew Beck , Dennis Gately , Nick Knudsen , Anthony Manibusan , Jianing Wang , Ying Sun
摘要： Antibody drug conjugates (ADCs) comprising an antibody conjugated to an anti-inflammatory therapeutic agent via a phosphate-based linker with tunable extracellular and intracellular stability are described.
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公开(公告)号：US10550190B2
公开(公告)日：2020-02-04
申请号：US15301564
申请日：2015-03-30
发明人： Robert M. Garbaccio , Jeffrey Kern , Philip E. Brandish , Sanjiv Shah , Linda Liang , Ying Sun , Jianing Wang , Nick Knudsen , Andrew Beck , Anthony Manibusan , Dennis Gately
摘要： Phosphate-based linkers with tunable stability for intracellular delivery of drug conjugates are described. The phosphate-based linkers comprise a monophosphate, diphosphate, triphosphate, or tetraphosphate group (phosphate group) and a linker arm comprising a tuning element and optionally a spacer. A payload is covalently linked to the phosphate group at the distal end of the linker arm and the functional group at the proximal end of the linker arm is covalently linked to a cell-specific targeting ligand such as an antibody. These phosphate-based linkers have a differentiated and tunable stability in blood vs. an intracellular environment (e.g. lysosomal compartment).
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公开(公告)号：US20200164085A1
公开(公告)日：2020-05-28
申请号：US15765515
申请日：2016-09-30
发明人： Philip E. Brandish , Robert M Garbaccio , Jeffrey Kern , Linda Liang , Sanjiv Shah , Dennis Zaller , Andrew Beck , Dennis Gately , Nick Knudsen , Anthony Manibusan , Jianing Wang , Ying Sun
摘要： Antibody drug conjugates (ADCs) comprising an antibody conjugated to an anti-inflammatory therapeutic agent via a phosphate-based linker with tunable extracellular and intracellular stability are described.
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公开(公告)号：US20170182181A1
公开(公告)日：2017-06-29
申请号：US15301564
申请日：2015-03-30
发明人： Robert M. Garbaccio , Jeffrey Kern , Philip E. Brandish , Sanjiv Shah , Linda Liang , Ying Sun , Jianing Wang , Nick Knudsen , Andrew Beck , Anthony Manibusan , Dennis Gately
CPC分类号： C07K16/2866 , A61K47/6803 , A61K47/6817 , A61K47/6849 , A61K47/6889 , A61K51/1045 , C07F9/091 , C07F9/098 , C07F9/12 , C07F9/2458 , C07F9/572 , C07F9/65517 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07H19/10
摘要： Phosphate-based linkers with tunable stability for intracellular delivery of drug conjugates are described. The phosphate-based linkers comprise a monophosphate, diphosphate, triphosphate, or tetraphosphate group (phosphate group) and a linker arm comprising a tuning element and optionally a spacer. A payload is covalently linked to the phosphate group at the distal end of the linker arm and the functional group at the proximal end of the linker arm is covalently linked to a cell-specific targeting ligand such as an antibody. These phosphate-based linkers have a differentiated and tunable stability in blood vs. an intracellular environment (e.g. lysosomal compartment).
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