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    GASTROINTESTINAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS
    1.
    发明申请
    GASTROINTESTINAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS 有权

    公开(公告)号：US20210259762A1

    公开(公告)日：2021-08-26

    申请号：US17313875

    申请日：2021-05-06

    Applicant: Medtronic Ardian Luxembourg S.a.r.l.

    Inventor： Neil Barman ,  Ayala Hezi-Yamit ,  Stefan Tunev

    IPC: A61B18/14 ,  A61B5/00 ,  A61B18/02 ,  A61B18/18 ,  A61B18/20 ,  A61N7/00

    Abstract: Methods for treating gastrointestinal conditions, conditions associated with sympathetic and/or parasympathetic activity in the gastrointestinal organs, and conditions associated with central sympathetic and/or parasympathetic activity in a patient with therapeutic gastrointestinalneuromodulation and associated systems and methods are disclosed herein. One aspect of the present technology is directed to methods that at least partially inhibit sympathetic neural activity in nerves proximate a gastrointestinal artery of a gastrointestinal organ of a patient. Sympathetic drive in the patient can thereby be reduced in a manner that treats the patient for the gastrointestinal condition.

    SYSTEMS, DEVICES, AND METHODS FOR MODULATING RENAL NERVE TISSUE
    2.
    发明公开
    SYSTEMS, DEVICES, AND METHODS FOR MODULATING RENAL NERVE TISSUE 审中-公开

    公开(公告)号：US20230181251A1

    公开(公告)日：2023-06-15

    申请号：US18163615

    申请日：2023-02-02

    Applicant: Medtronic Ardian Luxembourg S.a.r.l.

    Inventor： Robert Melder ,  Martin Rothman ,  Stefan Tunev

    IPC: A61B18/14

    CPC classification number: A61B18/1492 ,  A61B2018/00214

    Abstract: Methods for treating a patient using therapeutic renal neuromodulation and associated devices, system, and methods are disclosed herein. One aspect of the present technology is directed to neuromodulating nerve tissue in selected anatomical regions. In one embodiment, the method can include intravascularly advancing an elongate shaft of a catheter to renal vasculature of a human patient and locating a first neuromodulation element of the catheter within a distalmost portion of a main renal artery. The method includes locating a second neuromodulation element of the catheter within a branch vessel of the renal artery distal to a bifurcation at a distal end of the main renal artery. Neuromodulation of the nerve tissue surrounding the selected anatomical treatment locations can inhibit sympathetic neural activity in nerves proximate a portion of a renal artery and/or a renal branch artery proximate a renal parenchyma.

    SELECTIVE MODULATION OF RENAL NERVES
    3.
    发明申请
    SELECTIVE MODULATION OF RENAL NERVES 审中-公开

    公开(公告)号：US20190328439A1

    公开(公告)日：2019-10-31

    申请号：US16409442

    申请日：2019-05-10

    Applicant: Medtronic Ardian Luxembourg S.a.r.l.

    Inventor： Stefan Tunev ,  Julie Trudel

    IPC: A61B18/04 ,  A61N1/36 ,  A61B18/02 ,  A61N7/00 ,  A61N1/32 ,  A61B18/14 ,  A61B18/18 ,  A61N1/05 ,  A61M25/00

    Abstract: Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to methods including selectively neuromodulating afferent or efferent renal nerves. One or more measurable physiological parameters corresponding to systemic sympathetic overactivity or hyperactivity in the patient can thereby be reduced. Selectively neuromodulating afferent renal nerves can include inhibiting sympathetic neural activity in nerves proximate a renal pelvis. This can include, for example, neuromodulating via fluid within the renal pelvis. Selectively neuromodulating efferent renal nerves can include inhibiting sympathetic neural activity in nerves proximate a portion of a renal artery or a renal branch artery proximate a renal parenchyma. This can include, for example, neuromodulating via a therapeutic element within the portion of the renal artery or the renal branch artery.

    SYSTEMS, DEVICES, AND METHODS FOR MODULATING RENAL NERVE TISSUE
    4.
    发明申请
    SYSTEMS, DEVICES, AND METHODS FOR MODULATING RENAL NERVE TISSUE 审中-公开
    用于调节神经组织的系统，装置和方法

    公开(公告)号：US20150327924A1

    公开(公告)日：2015-11-19

    申请号：US14713604

    申请日：2015-05-15

    Applicant: Medtronic Ardian Luxembourg S.a.r.l.

    Inventor： Robert Melder ,  Martin Rothman ,  Stefan Tunev

    IPC: A61B18/14

    CPC classification number: A61B18/1492 ,  A61B18/082 ,  A61B18/24 ,  A61B2018/00214 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/1435 ,  A61B2018/1475 ,  A61B2018/1861 ,  A61N7/022

    Abstract: Methods for treating a patient using therapeutic renal neuromodulation and associated devices, system, and methods are disclosed herein. One aspect of the present technology is directed to neuromodulating nerve tissue in selected anatomical regions. In one embodiment, the method can include intravascularly advancing an elongate shaft of a catheter to renal vasculature of a human patient and locating a first neuromodulation element of the catheter within a distalmost portion of a main renal artery. The method includes locating a second neuromodulation element of the catheter within a branch vessel of the renal artery distal to a bifurcation at a distal end of the main renal artery. Neuromodulation of the nerve tissue surrounding the selected anatomical treatment locations can inhibit sympathetic neural activity in nerves proximate a portion of a renal artery and/or a renal branch artery proximate a renal parenchyma.

    Abstract translation: 本文公开了使用治疗性肾神经调节和相关装置，系统和方法治疗患者的方法。 本技术的一个方面是针对选择的解剖区域中的神经调节神经组织。 在一个实施例中，该方法可以包括将导管的细长轴血管内推进到人类患者的肾血管，并将导管的第一神经调节元件定位在主肾动脉的最远部分内。 该方法包括将导管的第二神经调节元件定位在远端主肾动脉末端的分叉处的肾动脉分支血管内。 围绕选择的解剖治疗位置的神经组织的神经调节可抑制靠近肾实质部分的肾动脉和/或肾分支动脉附近的神经中的交感神经活动。

    Selective modulation of renal nerves
    5.
    发明授权
    Selective modulation of renal nerves 有权

    公开(公告)号：US11457968B2

    公开(公告)日：2022-10-04

    申请号：US16409442

    申请日：2019-05-10

    Applicant: Medtronic Ardian Luxembourg S.a.r.l.

    Inventor： Stefan Tunev ,  Julie Trudel

    IPC: A61B18/02 ,  A61B18/04 ,  A61N1/05 ,  A61N1/36 ,  A61B18/14 ,  A61B18/18 ,  A61M25/00 ,  A61N1/32 ,  A61N7/00 ,  A61B18/00

    Abstract: Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to methods including selectively neuromodulating afferent or efferent renal nerves. One or more measurable physiological parameters corresponding to systemic sympathetic overactivity or hyperactivity in the patient can thereby be reduced. Selectively neuromodulating afferent renal nerves can include inhibiting sympathetic neural activity in nerves proximate a renal pelvis. This can include, for example, neuromodulating via fluid within the renal pelvis. Selectively neuromodulating efferent renal nerves can include inhibiting sympathetic neural activity in nerves proximate a portion of a renal artery or a renal branch artery proximate a renal parenchyma. This can include, for example, neuromodulating via a therapeutic element within the portion of the renal artery or the renal branch artery.

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