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    CATHETER APPARATUSES FOR MODULATION OF NERVES IN COMMUNICATION WITH THE PULMONARY SYSTEM AND ASSOCIATED SYSTEMS AND METHODS
    1.
    发明申请
    CATHETER APPARATUSES FOR MODULATION OF NERVES IN COMMUNICATION WITH THE PULMONARY SYSTEM AND ASSOCIATED SYSTEMS AND METHODS 有权

    公开(公告)号：US20220160424A1

    公开(公告)日：2022-05-26

    申请号：US17650352

    申请日：2022-02-08

    Applicant: Medtronic Ardian Luxembourg S.a.r.l.

    Inventor： Martin Rothman ,  Justin Goshgarian ,  William Chang

    IPC: A61B18/14

    Abstract: Devices, systems, and methods for the selective positioning of an intravascular neuromodulation device are disclosed herein. Such systems can include, for example, an elongated shaft and a therapeutic assembly carried by a distal portion of the elongated shaft. The therapeutic assembly is configured for delivery within a blood vessel. The therapeutic assembly can include a pre-formed shape and can be transformable between a substantially straight delivery configuration: and a treatment configuration having the pre-formed helical shape to position the therapeutic assembly in stable contact with a wall of the body vessel. The therapeutic assembly can also include a mechanical decoupler operably connected to the therapeutic assembly that is configured to absorb at least a portion of a force exerted on the therapeutic assembly by the shaft so that the therapeutic assembly maintains a generally stationary position relative to the target site.

    Catheter apparatuses for modulation of nerves in communication with the pulmonary system and associated systems and methods
    3.
    发明授权
    Catheter apparatuses for modulation of nerves in communication with the pulmonary system and associated systems and methods 有权

    公开(公告)号：US11154351B2

    公开(公告)日：2021-10-26

    申请号：US15516349

    申请日：2015-11-14

    Applicant: Medtronic Ardian Luxembourg S.a.r.l.

    Inventor： Martin Rothman ,  Paul Coates

    IPC: A61B18/14 ,  A61B18/02 ,  G01R5/26 ,  A61B18/00 ,  A61N7/00 ,  A61B90/00

    Abstract: Devices and systems for the selective positioning of an intravascular neuromodulation device are disclosed herein. Such systems can include, for example, an elongated shaft and a therapeutic assembly carried by a distal portion of the elongated shaft. The therapeutic assembly is configured for delivery within a blood vessel. The therapeutic assembly can include a pre-formed shape and can be transformable between a substantially straight delivery configuration; and a treatment configuration having the pre-formed helical shape to position the therapeutic assembly in stable contact with a wall of the body vessel. The therapeutic assembly can also include a mechanical decoupler operably connected to the therapeutic assembly that is configured to absorb at least a portion of a force exerted on the therapeutic assembly by the shaft so that the therapeutic assembly maintains a generally stationary position relative to the target site.

    SYSTEMS, DEVICES, AND METHODS FOR MODULATING RENAL NERVE TISSUE
    4.
    发明申请
    SYSTEMS, DEVICES, AND METHODS FOR MODULATING RENAL NERVE TISSUE 审中-公开
    用于调节神经组织的系统，装置和方法

    公开(公告)号：US20150327924A1

    公开(公告)日：2015-11-19

    申请号：US14713604

    申请日：2015-05-15

    Applicant: Medtronic Ardian Luxembourg S.a.r.l.

    Inventor： Robert Melder ,  Martin Rothman ,  Stefan Tunev

    IPC: A61B18/14

    CPC classification number: A61B18/1492 ,  A61B18/082 ,  A61B18/24 ,  A61B2018/00214 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/1435 ,  A61B2018/1475 ,  A61B2018/1861 ,  A61N7/022

    Abstract: Methods for treating a patient using therapeutic renal neuromodulation and associated devices, system, and methods are disclosed herein. One aspect of the present technology is directed to neuromodulating nerve tissue in selected anatomical regions. In one embodiment, the method can include intravascularly advancing an elongate shaft of a catheter to renal vasculature of a human patient and locating a first neuromodulation element of the catheter within a distalmost portion of a main renal artery. The method includes locating a second neuromodulation element of the catheter within a branch vessel of the renal artery distal to a bifurcation at a distal end of the main renal artery. Neuromodulation of the nerve tissue surrounding the selected anatomical treatment locations can inhibit sympathetic neural activity in nerves proximate a portion of a renal artery and/or a renal branch artery proximate a renal parenchyma.

    Abstract translation: 本文公开了使用治疗性肾神经调节和相关装置，系统和方法治疗患者的方法。 本技术的一个方面是针对选择的解剖区域中的神经调节神经组织。 在一个实施例中，该方法可以包括将导管的细长轴血管内推进到人类患者的肾血管，并将导管的第一神经调节元件定位在主肾动脉的最远部分内。 该方法包括将导管的第二神经调节元件定位在远端主肾动脉末端的分叉处的肾动脉分支血管内。 围绕选择的解剖治疗位置的神经组织的神经调节可抑制靠近肾实质部分的肾动脉和/或肾分支动脉附近的神经中的交感神经活动。

    SYSTEMS, DEVICES, AND METHODS FOR MODULATING RENAL NERVE TISSUE
    5.
    发明公开
    SYSTEMS, DEVICES, AND METHODS FOR MODULATING RENAL NERVE TISSUE 审中-公开

    公开(公告)号：US20230181251A1

    公开(公告)日：2023-06-15

    申请号：US18163615

    申请日：2023-02-02

    Applicant: Medtronic Ardian Luxembourg S.a.r.l.

    Inventor： Robert Melder ,  Martin Rothman ,  Stefan Tunev

    IPC: A61B18/14

    CPC classification number: A61B18/1492 ,  A61B2018/00214

    Abstract: Methods for treating a patient using therapeutic renal neuromodulation and associated devices, system, and methods are disclosed herein. One aspect of the present technology is directed to neuromodulating nerve tissue in selected anatomical regions. In one embodiment, the method can include intravascularly advancing an elongate shaft of a catheter to renal vasculature of a human patient and locating a first neuromodulation element of the catheter within a distalmost portion of a main renal artery. The method includes locating a second neuromodulation element of the catheter within a branch vessel of the renal artery distal to a bifurcation at a distal end of the main renal artery. Neuromodulation of the nerve tissue surrounding the selected anatomical treatment locations can inhibit sympathetic neural activity in nerves proximate a portion of a renal artery and/or a renal branch artery proximate a renal parenchyma.

    CATHETER APPARATUSES FOR MODULATION OF NERVES IN COMMUNICATION WITH THE PULMONARY SYSTEM AND ASSOCIATED SYSTEMS AND METHODS
    6.
    发明申请
    CATHETER APPARATUSES FOR MODULATION OF NERVES IN COMMUNICATION WITH THE PULMONARY SYSTEM AND ASSOCIATED SYSTEMS AND METHODS 有权

    公开(公告)号：US20220096153A1

    公开(公告)日：2022-03-31

    申请号：US17494648

    申请日：2021-10-05

    Applicant: Medtronic Ardian Luxembourg S.a.r.l.

    Inventor： Martin Rothman ,  Paul Coates

    IPC: A61B18/14 ,  A61B18/02 ,  G01R5/26

    Abstract: Devices, systems, and methods for the selective positioning of an intravascular neuromodulation device are disclosed herein. Such systems can include, for example, an elongated shaft and a therapeutic assembly carried by a distal portion of the elongated shaft. The therapeutic assembly is configured for delivery within a blood vessel. The therapeutic assembly can include a pre-formed shape and can be transformable between a substantially straight delivery configuration; and a treatment configuration having the pre-formed helical shape to position the therapeutic assembly in stable contact with a wall of the body vessel. The therapeutic assembly can also include a mechanical decoupler operably connected to the therapeutic assembly that is configured to absorb at least a portion of a force exerted on the therapeutic assembly by the shaft so that the therapeutic assembly maintains a generally stationary position relative to the target site.

    INTRAVASCULAR NEUROMODULATION DEVICE HAVING A HELICAL THERAPEUTIC ASSEMBLY WITH PROUD PORTIONS AND ASSOCIATED METHODS
    7.
    发明申请
    INTRAVASCULAR NEUROMODULATION DEVICE HAVING A HELICAL THERAPEUTIC ASSEMBLY WITH PROUD PORTIONS AND ASSOCIATED METHODS 审中-公开
    具有麻醉部位和相关方法的螺旋管理装置的血管内神经修复装置

    公开(公告)号：US20150359589A1

    公开(公告)日：2015-12-17

    申请号：US14301508

    申请日：2014-06-11

    Applicant: Medtronic Ardian Luxembourg S.a.r.l.

    Inventor： Kevin Mauch ,  Martin Rothman

    IPC: A61B18/14 ,  A61M25/09 ,  A61M25/00 ,  A61N1/05 ,  A61N1/36

    CPC classification number: A61B18/1492 ,  A61B2018/00214 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/1407 ,  A61B2018/1435 ,  A61M25/0045 ,  A61M25/09 ,  A61N1/05 ,  A61N1/36117

    Abstract: Catheter apparatuses, systems, and methods for achieving neuromodulation by intravascular access. A treatment device has a pre-formed helical therapeutic assembly with spaced-apart proud portions that are offset with respect to the pre-formed helical shape when in a deployed configuration. The therapeutic assembly includes a plurality of energy delivery elements carried by and associated with the proud portions such that, in the deployed configuration, the proud portions are configured to position the energy delivery elements in apposition with an inner wall of a target blood vessel. The energy delivery elements can deliver energy across the inner wall of a renal artery, for example, to heat or otherwise electrically modulate neural fibers that contribute to renal function.

    Abstract translation: 用于通过血管内通路实现神经调节的导管器械，系统和方法。 处理装置具有预先形成的螺旋治疗组件，其具有间隔开的自由部分，当处于展开构型时，该部分相对于预先形成的螺旋形状偏移。 治疗组件包括由骄傲部分携带并与其相关联的多个能量递送元件，使得在展开构造中，骄傲部分构造成将能量传递元件定位成与目标血管的内壁相对。 能量递送元件可以传递穿过肾动脉内壁的能量，例如加热或以其他方式电调节有助于肾功能的神经纤维。

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