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    Systems and methods for evaluating neuromodulation therapy via hemodynamic responses
    2.
    发明授权
    Systems and methods for evaluating neuromodulation therapy via hemodynamic responses 有权

    公开(公告)号：US11311205B2

    公开(公告)日：2022-04-26

    申请号：US16451395

    申请日：2019-06-25

    Applicant: Medtronic Ardian Luxembourg S.a.r.l.

    Inventor： Douglas Hettrick ,  Avram Scheiner

    IPC: A61B18/12 ,  A61B18/14 ,  A61B5/0538 ,  A61B5/00 ,  A61M25/00 ,  A61N1/05 ,  A61B18/00

    Abstract: Systems and methods for evaluating neuromodulation via hemodynamic responses are disclosed herein. A system configured in accordance with embodiments of the present technology can include, for example, a neuromodulation catheter comprising an elongated shaft having a distal portion, and a plurality of electrodes spaced along a distal portion. The system can further include a controller communicatively coupled to the electrodes. The controller can be configured to apply first and second stimuli at and/or proximate to a target site within a blood vessel before and after delivering neuromodulation energy to the target site, and detect, via at least one of the electrodes, vessel impedance resulting from the first and second stimuli to determine a baseline impedance and a post-neuromodulation impedance. The controller can further be configured to assess the efficacy of the neuromodulation based, at least in part, on a comparison of the baseline impedance and the post-neuromodulation impedance.

    SYSTEMS AND METHODS FOR ASSESSING EFFICACY OF RENAL NEUROMODULATION THERAPY
    4.
    发明申请
    SYSTEMS AND METHODS FOR ASSESSING EFFICACY OF RENAL NEUROMODULATION THERAPY 审中-公开

    公开(公告)号：US20200069196A1

    公开(公告)日：2020-03-05

    申请号：US16121472

    申请日：2018-09-04

    Applicant: Medtronic Ardian Luxembourg S.a.r.l.

    Inventor： Douglas Hettrick ,  Paul Coates

    IPC: A61B5/027 ,  A61B18/14 ,  A61B5/0275 ,  A61B5/00

    Abstract: Systems and methods for performing and assessing neuromodulation therapy are disclosed herein. One method for assessing the efficacy of neuromodulation therapy includes positioning a neuromodulation catheter at a target site within a renal blood vessel of a human patient and delivering neuromodulation energy at the target site with the neuromodulation catheter. The method can further include obtaining a measurement related to a blood flow rate through the renal blood vessel via the neuromodulation catheter. The measurement can be compared to a baseline measurement related to the blood flow rate through the renal blood vessel to assess the efficacy of the neuromodulation therapy. In some embodiments, the baseline and post-neuromodulation measurements are obtained by injecting an indicator fluid into the renal blood vessel upstream of the target site and detecting a transient change in vessel impedance caused by the indicator fluid.

    METHODS FOR TREATING DEPRESSION IN PATIENTS VIA RENAL NEUROMODULATION
    7.
    发明申请
    METHODS FOR TREATING DEPRESSION IN PATIENTS VIA RENAL NEUROMODULATION 审中-公开

    公开(公告)号：US20190008583A1

    公开(公告)日：2019-01-10

    申请号：US16026369

    申请日：2018-07-03

    Applicant: Medtronic Ardian Luxembourg S.a.r.l.

    Inventor： Marcia Gallagher ,  Douglas Hettrick

    IPC: A61B18/14 ,  A61B18/02 ,  A61N1/36 ,  G16H50/30

    Abstract: Methods for treating depression and for reducing a risk associated with developing depression in patients via therapeutic renal neuromodulation and associated systems are disclosed herein. Sympathetic nerve activity can contribute to several cellular and physiological conditions associated with depression as well as an increased risk of developing depression. One aspect of the present technology is directed to methods for improving a patient's calculated risk score corresponding to a depression status in the patient. Other aspects are directed to reducing a likelihood of developing depression in patients presenting one or more depression risk factors. Renal sympathetic nerve activity can be attenuated to improve a patient's depression status or risk of developing depression. The attenuation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly configured to use, e.g., electrically-induced, thermally-induced, and/or chemically-induced approaches to modulate the renal sympathetic nerve.

    Systems and methods for assessing efficacy of renal neuromodulation therapy
    9.
    发明授权
    Systems and methods for assessing efficacy of renal neuromodulation therapy 有权

    公开(公告)号：US11633120B2

    公开(公告)日：2023-04-25

    申请号：US16121472

    申请日：2018-09-04

    Applicant: Medtronic Ardian Luxembourg S.a.r.l.

    Inventor： Douglas Hettrick ,  Paul Coates

    IPC: A61B5/02 ,  A61B5/027 ,  A61B18/14 ,  A61B5/0275 ,  A61B5/00 ,  A61B18/00 ,  A61B18/02 ,  A61B18/16

    Abstract: Systems and methods for performing and assessing neuromodulation therapy are disclosed herein. One method for assessing the efficacy of neuromodulation therapy includes positioning a neuromodulation catheter at a target site within a renal blood vessel of a human patient and delivering neuromodulation energy at the target site with the neuromodulation catheter. The method can further include obtaining a measurement related to a blood flow rate through the renal blood vessel via the neuromodulation catheter. The measurement can be compared to a baseline measurement related to the blood flow rate through the renal blood vessel to assess the efficacy of the neuromodulation therapy. In some embodiments, the baseline and post-neuromodulation measurements are obtained by injecting an indicator fluid into the renal blood vessel upstream of the target site and detecting a transient change in vessel impedance caused by the indicator fluid.

    SYSTEMS AND METHODS FOR EVALUATING NEUROMODULATION THERAPY VIA HEMODYNAMIC RESPONSES
    10.
    发明申请
    SYSTEMS AND METHODS FOR EVALUATING NEUROMODULATION THERAPY VIA HEMODYNAMIC RESPONSES 有权

    公开(公告)号：US20220240807A1

    公开(公告)日：2022-08-04

    申请号：US17724906

    申请日：2022-04-20

    Applicant: Medtronic Ardian Luxembourg S.a.r.l.

    Inventor： Douglas Hettrick ,  Avram Scheiner

    IPC: A61B5/0538 ,  A61B18/12 ,  A61B18/14 ,  A61B5/00 ,  A61M25/00

    Abstract: Systems and methods for evaluating neuromodulation via hemodynamic responses are disclosed herein. A system configured in accordance with embodiments of the present technology can include, for example, a neuromodulation catheter comprising an elongated shaft having a distal portion, and a plurality of electrodes spaced along a distal portion. The system can further include a controller communicatively coupled to the electrodes. The controller can be configured to apply first and second stimuli at and/or proximate to a target site within a blood vessel before and after delivering neuromodulation energy to the target site, and detect, via at least one of the electrodes, vessel impedance resulting from the first and second stimuli to determine a baseline impedance and a post-neuromodulation impedance. The controller can further be configured to assess the efficacy of the neuromodulation based, at least in part, on a comparison of the baseline impedance and the post-neuromodulation impedance.

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