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公开(公告)号：US20170107473A1
公开(公告)日：2017-04-20
申请号：US15161112
申请日：2016-05-20
Applicant: Massachusetts Institute of Technology , Sanofi
Inventor： Shireen Goh , Rajeev Jagga Ram , Michelangelo Canzoneri , Horst Blum
CPC classification number: C12M41/34 , B01L3/502723 , C12M23/24 , C12M23/26 , C12M23/34 , C12M29/04 , C12M41/26 , C12M41/32 , C12M41/44
Abstract: Strategies to control the level of dissolved carbon dioxide (CO2) concentrations and/or pH in small volume reactor chambers, and associated articles, systems, and methods, are generally provided. In certain embodiments, the reactor chambers can be configured to contain at least one biological cell.
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公开(公告)号：US11827871B2
公开(公告)日：2023-11-28
申请号：US16673805
申请日：2019-11-04
Applicant: Massachusetts Institute of Technology , Sanofi
Inventor： Shireen Goh , Rajeev Jagga Ram , Michelangelo Canzoneri , Horst Blum
Abstract: Control of volume in bioreactors and associated systems is generally described. Feeding and/or sampling strategies can be employed, in some embodiments, such that the working volume within the bioreactor remains substantially constant.
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公开(公告)号：US20220411741A1
公开(公告)日：2022-12-29
申请号：US17897489
申请日：2022-08-29
Applicant: Sanofi , Massachusetts Institute of Technology
Inventor： Shireen Goh , Rajeev Jagga Ram , Kevin Shao-Kwan Lee , Michelangelo Canzoneri , Horst Blum
Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.
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4.发明申请SMALL VOLUME BIOREACTORS WITH SUBSTANTIALLY CONSTANT WORKING VOLUMES AND ASSOCIATED SYSTEMS AND METHODS 审中-公开具有大量恒定工作量和相关系统和方法的小容量生物反应器公开(公告)号：US20160215246A1
公开(公告)日：2016-07-28
申请号：US14913734
申请日：2014-08-22
Applicant: Massachusetts Institute of Technology , SANOFI
Inventor： Shireen Goh , Rajeev Jagga Ram , Michelangelo Canzoneri , Horst Blum
Abstract: Control of volume in bioreactors and associated systems is generally described. Feeding and/or sampling strategies can be employed, in some embodiments, such that the working volume within the bioreactor remains substantially constant.
Abstract translation: 通常描述生物反应器和相关系统中体积的控制。 在一些实施方案中，可以采用进料和/或取样策略，使得生物反应器内的工作体积保持基本恒定。
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公开(公告)号：US11459538B2
公开(公告)日：2022-10-04
申请号：US16654808
申请日：2019-10-16
Applicant: Sanofi , Massachusetts Institute of Technology
Inventor： Shireen Goh , Rajeev Jagga Ram , Kevin Shao-Kwan Lee , Michelangelo Canzoneri , Horst Blum
Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.
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Patent Agency Ranking
公开(公告)号：US20200040298A1
公开(公告)日：2020-02-06
申请号：US16654808
申请日：2019-10-16
Applicant: Sanofi , Massachusetts Institute of Technology
Inventor： Shireen Goh , Rajeev Jagga Ram , Kevin Shao-Kwan Lee , Michelangelo Canzoneri , Horst Blum
Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.
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公开(公告)号：US10472602B2
公开(公告)日：2019-11-12
申请号：US14064021
申请日：2013-10-25
Applicant: Massachusetts Institute of Technology
Inventor： Shireen Goh , Rajeev Jagga Ram , Kevin Shao-Kwan Lee , Michelangelo Canzoneri , Horst Blum
Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.
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公开(公告)号：US20140120609A1
公开(公告)日：2014-05-01
申请号：US14064021
申请日：2013-10-25
Applicant: Massachusetts Institute of Technology
Inventor： Shireen Goh , Rajeev Jagga Ram , Kevin Shao-Kwan Lee , Michelangelo Canzoneri , Horst Blum
IPC: C12M1/34
Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.
Abstract translation: 通常描述化学反应器中的湿度控制以及相关系统和方法。 在某些实施例中，可以控制气体输送导管和腔室内的湿度以抑制气体输送路径内的不需要的冷凝。 通过抑制气体输送通道内的冷凝，可以限制（或消除）这种途径的堵塞，使得气体的输送可以更容易和可控地实现。 此外，还描述了用于从化学反应器系统中吹扫冷凝液体的策略。
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公开(公告)号：US11725176B2
公开(公告)日：2023-08-15
申请号：US17897489
申请日：2022-08-29
Applicant: Sanofi , Massachusetts Institute of Technology
Inventor： Shireen Goh , Rajeev Jagga Ram , Kevin Shao-Kwan Lee , Michelangelo Canzoneri , Horst Blum
CPC classification number: C12M41/44 , B01J19/0006 , C12M23/24 , C12M29/26 , C12M41/34
Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.
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10.发明授权公开(公告)号：US10479973B2
公开(公告)日：2019-11-19
申请号：US14913734
申请日：2014-08-22
Applicant: Massachusetts Institute of Technology , Sanofi
Inventor： Shireen Goh , Rajeev Jagga Ram , Michelangelo Canzoneri , Horst Blum
Abstract: Control of volume in bioreactors and associated systems is generally described. Feeding and/or sampling strategies can be employed, in some embodiments, such that the working volume within the bioreactor remains substantially constant.
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