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    MUTANT SOX PROTEINS AND METHODS OF INDUCING PLURIPOTENCY
    5.
    发明申请
    MUTANT SOX PROTEINS AND METHODS OF INDUCING PLURIPOTENCY 有权
    突变型SOX蛋白及其诱导方法

    公开(公告)号：US20120220029A1

    公开(公告)日：2012-08-30

    申请号：US13505369

    申请日：2010-11-04

    申请人： Prasanna R. Kolatkar ,  Irene Aksoy ,  Ralf Jauch ,  Lawrence W. Stanton

    发明人： Prasanna R. Kolatkar ,  Irene Aksoy ,  Ralf Jauch ,  Lawrence W. Stanton

    IPC分类号： C07K14/435 ,  C12N5/10 ,  C12N15/12

    CPC分类号： C07K14/4702 ,  C12N15/62

    摘要： There is presently provided mutant Sox2, Sox7 and Sox17 proteins that have acquired or increased ability to induce pluripotency in a partially differentiated or fully differentiated cell. Sox7 and Sox17 are mutated to resemble in part Sox2, or Sox2 is mutated to resemble in part Sox7 or Sox17. In one aspect, the Oct4 contact interface of Sox7 or Sox17 is mutated. In another aspect, the high mobility group (HMG) of Sox2 is fused to the C-terminal activation domain of Sox7 or Sox17. Methods relating to inducing pluripotency using a mutant Sox2, Sox7 or Sox17 protein are also provided.

    摘要翻译： 目前提供了在部分分化或完全分化的细胞中获得或增加诱导多能性的能力的突变Sox2，Sox7和Sox17蛋白。 Sox7和Sox17被突变以类似于部分Sox2，或者Sox2被突变以类似于部分Sox7或Sox17。 在一方面，Sox7或Sox17的Oct4接触界面被突变。 另一方面，Sox2的高迁移率组（HMG）融合到Sox7或Sox17的C末端激活结构域。 还提供了使用突变Sox2，Sox7或Sox17蛋白诱导多能性的方法。

    Mutant sox proteins and methods of inducing pluripotency
    6.
    发明授权
    Mutant sox proteins and methods of inducing pluripotency 有权
    突变型sox蛋白和诱导多能性的方法

    公开(公告)号：US08907055B2

    公开(公告)日：2014-12-09

    申请号：US13505369

    申请日：2010-11-04

    申请人： Prasanna R. Kolatkar ,  Irene Aksoy ,  Ralf Jauch ,  Lawrence W. Stanton

    发明人： Prasanna R. Kolatkar ,  Irene Aksoy ,  Ralf Jauch ,  Lawrence W. Stanton

    IPC分类号： A61K38/00 ,  C07H21/04 ,  C12N5/00

    CPC分类号： C07K14/4702 ,  C12N15/62

    摘要： There is presently provided mutant Sox2, Sox7 and Sox17 proteins that have acquired or increased ability to induce pluripotency in a partially differentiated or fully differentiated cell. Sox7 and Sox17 are mutated to resemble in part Sox2, or Sox2 is mutated to resemble in part Sox7 or Sox17. In one aspect, the Oct4 contact interface of Sox7 or Sox17 is mutated. In another aspect, the high mobility group (HMG) of Sox2 is fused to the C-terminal activation domain of Sox7 or Sox17. Methods relating to inducing pluripotency using a mutant Sox2, Sox7 or Sox17 protein are also provided.

    摘要翻译： 目前提供了在部分分化或完全分化的细胞中获得或增加诱导多能性的能力的突变Sox2，Sox7和Sox17蛋白。 Sox7和Sox17被突变以类似于部分Sox2，或者Sox2被突变以类似于部分Sox7或Sox17。 在一方面，Sox7或Sox17的Oct4接触界面被突变。 另一方面，Sox2的高迁移率组（HMG）融合到Sox7或Sox17的C末端激活结构域。 还提供了使用突变Sox2，Sox7或Sox17蛋白诱导多能性的方法。