公开(公告)号：US20100156244A1

公开(公告)日：2010-06-24

申请号：US12562998

申请日：2009-09-18

申请人： Marc Lukacs ,  Chris Chaggares ,  Desmond Hirson ,  Guofeng Pang

发明人： Marc Lukacs ,  Chris Chaggares ,  Desmond Hirson ,  Guofeng Pang

IPC分类号： B06B1/06 ,  H01L41/22 ,  H04R31/00

CPC分类号： A61B8/543 ,  A61B8/13 ,  A61B8/14 ,  B06B1/0622 ,  H01L41/29 ,  Y10T29/42 ,  Y10T29/49005 ,  Y10T29/49156 ,  Y10T29/49169

摘要： The invention features methods for the manufacture of electrical components such as ultrasound transducers. In particular, the inventions provides methods of patterning electrodes, e.g., in the connection of an ultrasound transducer to an electrical circuit; methods of depositing metal on surfaces; and methods of making integrated matching layer for an ultrasound transducer. The invention also features ultrasound transducers produced by the methods described herein.

摘要翻译： 本发明的特征在于制造诸如超声换能器的电气部件的方法。 特别地，本发明提供了图案化电极的方法，例如在超声换能器与电路的连接中; 在表面上沉积金属的方法; 以及制造用于超声换能器的集成匹配层的方法。 本发明还具有通过本文所述的方法产生的超声换能器。

公开(公告)号：US08316518B2

公开(公告)日：2012-11-27

申请号：US12562998

申请日：2009-09-18

申请人： Marc Lukacs ,  Chris Chaggares ,  Desmond Hirson ,  Guofeng Pang

发明人： Marc Lukacs ,  Chris Chaggares ,  Desmond Hirson ,  Guofeng Pang

IPC分类号： H04R17/10 ,  B23K26/38 ,  H05K3/08

CPC分类号： A61B8/543 ,  A61B8/13 ,  A61B8/14 ,  B06B1/0622 ,  H01L41/29 ,  Y10T29/42 ,  Y10T29/49005 ,  Y10T29/49156 ,  Y10T29/49169

摘要： Methods for the manufacture of electrical components, such as ultrasound transducers, are illustrated and described. In particular, several embodiments of the methods can include patterning electrodes, such as for the connection of an ultrasound transducer to an electrical circuit. The methods also can include depositing metal on surfaces and making an integrated matching layer for an ultrasound transducer. Ultrasound transducers produced by these methods also are illustrated and described.

摘要翻译： 图示和描述了用于制造诸如超声换能器的电气部件的方法。 特别地，该方法的几个实施例可以包括图案化电极，例如用于将超声换能器连接到电路。 所述方法还可以包括在表面上沉积金属并制成用于超声换能器的集成匹配层。 通过这些方法产生的超声换能器也被示出和描述。

公开(公告)号：US07830069B2

公开(公告)日：2010-11-09

申请号：US11621884

申请日：2007-01-10

申请人： Marc Lukacs ,  F. Stuart Foster

发明人： Marc Lukacs ,  F. Stuart Foster

IPC分类号： H01L41/083

CPC分类号： B06B1/0622

摘要： An ultrasonic transducer comprises a stack having a first face, an opposed second face and a longitudinal axis extending therebetween. The stack comprises a plurality of layers, each layer having a top surface and an opposed bottom surface, wherein the plurality of layers of the stack comprises a piezoelectric layer and a dielectric layer. The dielectric layer is connected to the piezoelectric layer and defines an opening extending a second predetermined length in a direction substantially parallel to the axis of the stack. A plurality of first kerf slots are defined therein the stack, each first kerf slot extending a predetermined depth therein the stack and a first predetermined length in a direction substantially parallel to the axis. The first predetermined length of each first kerf slot is at least as long as the second predetermined length of the opening defined by the dielectric layer and is shorter than the longitudinal distance between the first face and the opposed second face of the stack in a lengthwise direction substantially parallel to the axis.

摘要翻译： 超声波换能器包括具有第一面，相对的第二面和在它们之间延伸的纵轴的叠层。 所述堆叠包括多个层，每个层具有顶表面和相对的底表面，其中堆叠的多个层包括压电层和电介质层。 电介质层连接到压电层并且限定了在基本上平行于堆叠的轴线的方向上延伸第二预定长度的开口。 在其中限定了多个第一切口槽，每个第一切口槽在堆叠中延伸预定深度，并且在基本上平行于轴线的方向上延伸第一预定长度。 每个第一切口槽的第一预定长度至少等于由电介质层限定的开口的第二预定长度，并且短于堆叠的第一面和相对的第二面之间在纵向上的纵向距离 基本上平行于轴线。

公开(公告)号：US09532769B2

公开(公告)日：2017-01-03

申请号：US13393500

申请日：2010-09-07

申请人： Paul A. Dayton ,  Ryan Gessner ,  Hyunggyun Lee ,  Marc Lukacs ,  Francis Stuart Foster

发明人： Paul A. Dayton ,  Ryan Gessner ,  Hyunggyun Lee ,  Marc Lukacs ,  Francis Stuart Foster

IPC分类号： A61B8/00 ,  A61B8/08 ,  A61M37/00

CPC分类号： A61B8/481 ,  A61M37/0092

摘要： Systems, methods, and computer readable media for high-frequency contrast imaging and image-guided therapeutics are disclosed. According to one aspect a method for high frequency contrast imaging and image-guided therapeutics includes: providing ultrasound of a first frequency bandwidth, directed toward the volume to be imaged, the volume containing a carrier having non-linear acoustical properties, wherein the ultrasound of the first frequency bandwidth causes the carrier to generate ultrasound of a second frequency bandwidth that is different from the first frequency bandwidth; receiving, from the volume to be imaged, ultrasound of the second frequency bandwidth; and using the received ultrasound of the second frequency bandwidth to generate an image of the volume to be imaged, wherein the components of the second frequency bandwidth that are detected are of a frequency greater than 20 MHz. According to another aspect, ultrasound at a first frequency bandwidth enables imaging of a target, and ultrasound at a second frequency bandwidth mediates drug or gene delivery to a portion of the target, as guided by the image provided by the first frequency.

摘要翻译： 公开了用于高频对比成像和图像引导治疗剂的系统，方法和计算机可读介质。 根据一个方面，用于高频对比成像和图像引导治疗的方法包括：提供针对待成像的体积的第一频率带宽的超声波，该体积包含具有非线性声学特性的载体，其中超声波 所述第一频率带宽使所述载波产生与所述第一频带宽度不同的第二频带宽度的超声波; 从要成像的体积中接收第二频带的超声波; 以及使用所接收的所述第二频率带宽的超声波产生要成像的体积的图像，其中所检测的所述第二频率带宽的分量具有大于20MHz的频率。 根据另一方面，在第一频率带宽上的超声使得能够对目标进行成像，并且在由第一频率提供的图像的指导下，以第二频率带宽的超声介导药物或基因递送到目标的一部分。

公开(公告)号：US07230368B2

公开(公告)日：2007-06-12

申请号：US11109986

申请日：2005-04-20

申请人： Marc Lukacs ,  F. Stuart Foster

发明人： Marc Lukacs ,  F. Stuart Foster

IPC分类号： H01L41/083

CPC分类号： B06B1/0622

摘要： An ultrasonic transducer comprises a stack having a first face, an opposed second face and a longitudinal axis extending therebetween. The stack comprises a plurality of layers, each layer having a top surface and an opposed bottom surface, wherein the plurality of layers of the stack comprises a piezoelectric layer and a dielectric layer. The dielectric layer is connected to the piezoelectric layer and defines an opening extending a second predetermined length in a direction substantially parallel to the axis of the stack. A plurality of first kerf slots are defined therein the stack, each first kerf slot extending a predetermined depth therein the stack and a first predetermined length in a direction substantially parallel to the axis. The first predetermined length of each first kerf slot is at least as long as the second predetermined length of the opening defined by the dielectric layer and is shorter than the longitudinal distance between the first face and the opposed second face of the stack in a lengthwise direction substantially parallel to the axis.

摘要翻译： 超声波换能器包括具有第一面，相对的第二面和在它们之间延伸的纵轴的叠层。 所述堆叠包括多个层，每个层具有顶表面和相对的底表面，其中堆叠的多个层包括压电层和电介质层。 电介质层连接到压电层并且限定了在基本上平行于堆叠的轴线的方向上延伸第二预定长度的开口。 在其中限定了多个第一切口槽，每个第一切口槽在堆叠中延伸预定深度，并且在基本上平行于轴线的方向上延伸第一预定长度。 每个第一切口槽的第一预定长度至少等于由电介质层限定的开口的第二预定长度，并且短于堆叠的第一面和相对的第二面之间在纵向上的纵向距离 基本上平行于轴线。

公开(公告)号：US20120220869A1

公开(公告)日：2012-08-30

申请号：US13393500

申请日：2010-09-07

申请人： Paul A. Dayton ,  Ryan Gessner ,  Hyunggyun Lee ,  Marc Lukacs ,  Francis Stuart Foster

发明人： Paul A. Dayton ,  Ryan Gessner ,  Hyunggyun Lee ,  Marc Lukacs ,  Francis Stuart Foster

IPC分类号： A61B8/14

CPC分类号： A61B8/481 ,  A61M37/0092

摘要： Systems, methods, and computer readable media for high-frequency contrast imaging and image-guided therapeutics are disclosed. According to one aspect a method for high frequency contrast imaging and image-guided therapeutics includes: providing ultrasound of a first frequency bandwidth, directed toward the volume to be imaged, the volume containing a carrier having non-linear acoustical properties, wherein the ultrasound of the first frequency bandwidth causes the carrier to generate ultrasound of a second frequency bandwidth that is different from the first frequency bandwidth; receiving, from the volume to be imaged, ultrasound of the second frequency bandwidth; and using the received ultrasound of the second frequency bandwidth to generate an image of the volume to be imaged, wherein the components of the second frequency bandwidth that are detected are of a frequency greater than 20 MHz. According to another aspect, ultrasound at a first frequency bandwidth enables imaging of a target, and ultrasound at a second frequency bandwidth mediates drug or gene delivery to a portion of the target, as guided by the image provided by the first frequency.

摘要翻译： 公开了用于高频对比成像和图像引导治疗剂的系统，方法和计算机可读介质。 根据一个方面，用于高频对比成像和图像引导治疗的方法包括：提供针对待成像的体积的第一频率带宽的超声波，该体积包含具有非线性声学特性的载体，其中超声波 所述第一频率带宽使所述载波产生与所述第一频带宽度不同的第二频带宽度的超声波; 从要成像的体积中接收第二频带的超声波; 以及使用所接收的所述第二频率带宽的超声波产生要成像的体积的图像，其中所检测的所述第二频率带宽的分量具有大于20MHz的频率。 根据另一方面，在第一频率带宽上的超声使得能够对目标进行成像，并且在由第一频率提供的图像的指导下，以第二频率带宽的超声介导药物或基因递送到目标的一部分。

公开(公告)号：US20070182287A1

公开(公告)日：2007-08-09

申请号：US11621884

申请日：2007-01-10

申请人： Marc Lukacs ,  F. Foster

发明人： Marc Lukacs ,  F. Foster

IPC分类号： H01L41/08

CPC分类号： B06B1/0622

摘要： An ultrasonic transducer comprises a stack having a first face, an opposed second face and a longitudinal axis extending therebetween. The stack comprises a plurality of layers, each layer having a top surface and an opposed bottom surface, wherein the plurality of layers of the stack comprises a piezoelectric layer and a dielectric layer. The dielectric layer is connected to the piezoelectric layer and defines an opening extending a second predetermined length in a direction substantially parallel to the axis of the stack. A plurality of first kerf slots are defined therein the stack, each first kerf slot extending a predetermined depth therein the stack and a first predetermined length in a direction substantially parallel to the axis. The first predetermined length of each first kerf slot is at least as long as the second predetermined length of the opening defined by the dielectric layer and is shorter than the longitudinal distance between the first face and the opposed second face of the stack in a lengthwise direction substantially parallel to the axis.

摘要翻译： 超声波换能器包括具有第一面，相对的第二面和在它们之间延伸的纵轴的叠层。 所述堆叠包括多个层，每个层具有顶表面和相对的底表面，其中堆叠的多个层包括压电层和电介质层。 电介质层连接到压电层并且限定了在基本上平行于堆叠的轴线的方向上延伸第二预定长度的开口。 在其中限定了多个第一切口槽，每个第一切口槽在堆叠中延伸预定深度，并且在基本上平行于轴线的方向上延伸第一预定长度。 每个第一切口槽的第一预定长度至少等于由电介质层限定的开口的第二预定长度，并且短于堆叠的第一面和相对的第二面之间在纵向上的纵向距离 基本上平行于轴线。

公开(公告)号：US20050272183A1

公开(公告)日：2005-12-08

申请号：US11109986

申请日：2005-04-20

申请人： Marc Lukacs ,  F. Foster

发明人： Marc Lukacs ,  F. Foster

IPC分类号： B06B1/06 ,  H01L21/44 ,  H01L21/48

CPC分类号： B06B1/0622

摘要： An ultrasonic transducer comprises a stack having a first face, an opposed second face and a longitudinal axis extending therebetween. The stack comprises a plurality of layers, each layer having a top surface and an opposed bottom surface, wherein the plurality of layers of the stack comprises a piezoelectric layer and a dielectric layer. The dielectric layer is connected to the piezoelectric layer and defines an opening extending a second predetermined length in a direction substantially parallel to the axis of the stack. A plurality of first kerf slots are defined therein the stack, each first kerf slot extending a predetermined depth therein the stack and a first predetermined length in a direction substantially parallel to the axis. The first predetermined length of each first kerf slot is at least as long as the second predetermined length of the opening defined by the dielectric layer and is shorter than the longitudinal distance between the first face and the opposed second face of the stack in a lengthwise direction substantially parallel to the axis.

摘要翻译： 超声波换能器包括具有第一面，相对的第二面和在它们之间延伸的纵轴的叠层。 所述堆叠包括多个层，每个层具有顶表面和相对的底表面，其中堆叠的多个层包括压电层和电介质层。 电介质层连接到压电层并且限定了在基本上平行于堆叠的轴线的方向上延伸第二预定长度的开口。 在其中限定了多个第一切口槽，每个第一切口槽在堆叠中延伸预定深度，并且在基本上平行于轴线的方向上延伸第一预定长度。 每个第一切口槽的第一预定长度至少等于由电介质层限定的开口的第二预定长度，并且短于堆叠的第一面和相对的第二面之间在纵向上的纵向距离 基本上平行于轴线。