公开(公告)号：US20100316612A1

公开(公告)日：2010-12-16

申请号：US12626567

申请日：2009-11-25

申请人： MOON JONG NOH ,  YOUNGSUK YI ,  KWAN HEE LEE

发明人： MOON JONG NOH ,  YOUNGSUK YI ,  KWAN HEE LEE

IPC分类号： A61K38/19 ,  A61P43/00 ,  A61P19/02 ,  C12N5/077 ,  C12N5/071

CPC分类号： C12N5/0655 ,  A61K35/12 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/155

摘要： The subject invention is directed to a composition comprising primed connective tissue cells and a pharmaceutically acceptable carrier thereof.

摘要翻译： 本发明涉及包含底漆的结缔组织细胞及其药学上可接受的载体的组合物。

公开(公告)号：US20230190819A1

公开(公告)日：2023-06-22

申请号：US17055573

申请日：2020-05-06

申请人： YOUNGSUK YI

发明人： YOUNGSUK YI

IPC分类号： A61K35/32 ,  A61K47/42 ,  A61K38/18 ,  A61K35/33 ,  A61K35/30 ,  C12N5/0793 ,  C12N5/079

CPC分类号： A61K35/32 ,  A61K47/42 ,  A61K38/1841 ,  A61K35/33 ,  A61K35/30 ,  C12N5/0619 ,  C12N5/0622 ,  C12N2506/45 ,  C12N2506/1353

摘要： Disclosed herein is a technology platform for delivering macromolecules of interest to a subject over a period of time without repeated administration. The compositions disclosed herein are comprised of genetically modified cells, engineered exosomes, and adhesive scaffold materials. The compositions are designed to sustain the supply macromolecules of interest at a site of administration for a long period of time ranging from days to months.

公开(公告)号：US20240024220A1

公开(公告)日：2024-01-25

申请号：US17055572

申请日：2020-05-06

申请人： YOUNGSUK YI

发明人： YOUNGSUK YI

IPC分类号： A61K8/64 ,  C12N5/0793 ,  C07K1/36

CPC分类号： A61K8/64 ,  C12N5/0619 ,  C07K1/36 ,  C12N2506/45

摘要： Present invention provides improved compositions and methods of releasing cargo molecules to recipient cells. Described herein are engineered exosomes carrying neurotoxins and/or compounds, and releasing the neurotoxins to recipient cells by permeating the skin.