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公开(公告)号：US20230151398A1
公开(公告)日：2023-05-18
申请号：US17797907
申请日：2021-02-08
Applicant: METABOLIC EXPLORER
Inventor： Laurence DUMON-SEIGNOVERT , Céline RAYNAUD , Thomas DESFOUGERES
CPC classification number: C12P17/12 , C12N9/1025 , C12Y203/01178 , C12Y203/03001
Abstract: The present invention relates to a microorganism genetically modified for production of ectoine, wherein said microorganism comprises the following modifications: expression of a heterologous gene ectA encoding a diaminobutyric acid acetyltransferase having at least 90% similarity with SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4 or SEQ ID NO: 5, a heterologous gene ectB encoding a diaminobutyric acid aminotransferase having at least 90% similarity with SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9 or SEQ ID NO: 10, a heterologous gene ectC encoding an ectoine synthase having at least 90% similarity with SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14 or SEQ ID NO: 15 and deletion of pykA and pykF genes. The present invention also relates to a method for the production of ectoine using said microorganism.
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公开(公告)号：US20230357808A1
公开(公告)日：2023-11-09
申请号：US18023960
申请日：2021-09-01
Applicant: METABOLIC EXPLORER
Inventor： Laurence DUMON-SEIGNOVERT , Céline RAYNAUD
CPC classification number: C12P13/06 , C12N9/0016 , C12Y104/01001
Abstract: The present invention relates to a microorganism genetically modified for improved production of alanine, wherein the microorganism expresses a heterologous alaD gene coding an alanine dehydrogenase and has reduced Lrp transcription factor activity and/or expression. The present invention also relates to a method for the production of alanine using said microorganism.
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公开(公告)号：US20210254108A1
公开(公告)日：2021-08-19
申请号：US17267347
申请日：2019-08-09
Applicant: METABOLIC EXPLORER
Inventor： Wanda DISCHERT , Céline RAYNAUD , Laurence DUMON-SEIGNOVERT , Nadège DUMOULIN
Abstract: The present invention concerns a new mutant strain of Clostridium acetobutylicum comprising attenuated glycerol kinase activity. In addition, the present invention concerns a consortium of Clostridium comprising at least said mutant strain and at least one other species of Clostridium chosen among C. sporogenes and C. sphenoides. As this modified strain may be adapted for growth and for the production of 1,3-propanediol in an appropriate culture medium with high glycerol content, the invention also relates to a method for the production of 1,3-propanediol and butyric acid, by culturing at least this mutant strain in an appropriate culture medium.
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公开(公告)号：US20180312890A1
公开(公告)日：2018-11-01
申请号：US15770449
申请日：2015-10-23
Applicant: METABOLIC EXPLORER
Inventor： Gwenaëlle CORRE , Laurence DUMON-SEIGNOVERT , Philippe SOUCAILLE
CPC classification number: C12P17/18 , C12N1/16 , C12N1/20 , C12N9/1029 , C12N9/13 , C12N9/93 , C12N15/52 , C12N15/70 , C12N15/81 , C12P7/065 , C12P7/16 , C12P7/18 , C12P7/42 , C12P7/46 , C12P13/08 , C12P13/12 , C12Y203/01009 , C12Y203/01016 , C12Y208/03005 , C12Y208/03008 , C12Y602/01 , Y02E50/10 , Y02E50/17
Abstract: The present invention relates to a genetically modified microorganism for the fermentative conversion of levulinic acid into propionyl-CoA and acetyl-CoA, and to a fermentation process for performing said conversion.
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Patent Agency Ranking
5.发明申请公开(公告)号：US20160177351A1
公开(公告)日：2016-06-23
申请号：US14915128
申请日：2014-09-01
Applicant: METABOLIC EXPLORER
Inventor： Rainer FIGGE , Laurence DUMON-SEIGNOVERT
Abstract: The present invention is related to a recombinant Escherichia coli (E. coli) strain optimised for the fermentative production of methionine and/or its derivatives, wherein in said recombinant strain, the methionine import is attenuated and the methionine efflux is enhanced. It is also related to a method for optimising the fermentative production of methionine or its derivatives comprising the steps of: a. culturing a recombinant microorganism wherein in said microorganism, the methionine import is attenuated and the methionine efflux is enhanced, in an appropriate culture medium comprising a fermentable source of carbon and a source of sulphur, and b. recovering methionine and/or its derivatives from the culture medium.
Abstract translation: 本发明涉及针对甲硫氨酸和/或其衍生物的发酵产生优化的重组大肠杆菌（E.coli）菌株，其中在所述重组菌株中，导入的甲硫氨酸减毒，并且甲硫氨酸流出增强。 它还涉及用于优化甲硫氨酸或其衍生物的发酵生产的方法，包括以下步骤：a。 培养重组微生物，其中在包含可发酵碳源和硫源的适当培养基中，在所述微生物中，导入甲硫氨酸并且甲硫氨酸流出增强，b。 从培养基中回收甲硫氨酸和/或其衍生物。
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6.发明申请公开(公告)号：US20200181652A1
公开(公告)日：2020-06-11
申请号：US16465560
申请日：2017-12-29
Applicant: METABOLIC EXPLORER
Inventor： Laetitia FAURE , Gwenaëlle CORRE , Céline RAYNAUD , Laurence DUMON-SEIGNOVERT
Abstract: The present invention relates to new methylglyoxal reductase (MGR) enzymes which are useful for efficiently converting methylglyoxal into hydroxyacetone. The invention more particularly relates to a method for efficiently converting methylglyoxal into hydroxyacetone using said enzymes, to a method for producing 1,2-propanediol using a microorganism overexpressing said enzymes, and to said microorganism.
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7.发明申请公开(公告)号：US20180105845A1
公开(公告)日：2018-04-19
申请号：US15564943
申请日：2016-04-07
Applicant: METABOLIC EXPLORER
Inventor： Wanda DISCHERT , Laurence DUMON-SEIGNOVERT , Perrine VASSEUR , Gwénaëlle BESTEL-CORRE , Philippe SOUCAILLE
CPC classification number: C12P7/42 , C07K14/245 , C07K14/39 , C07K14/395 , C12N9/0006 , C12N9/0008 , C12N9/18 , C12N15/52 , C12Y101/01175 , C12Y301/01068
Abstract: The present invention relates to a recombinant microorganism capable of producing 2,4-dihydroxybutyrate, which is characterized by an increased cellular export, and preferably by a decreased cellular import, of said 2,4 DHB. The invention also relates to a method for the optimized productionof 2,4-dihydroxybutyrate by culturing said microorganism in a fermentation medium and recovering 2,4-DHB from said medium.
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公开(公告)号：US20180100169A1
公开(公告)日：2018-04-12
申请号：US15564919
申请日：2015-04-07
Applicant: METABOLIC EXPLORER
CPC classification number: C12P7/42 , C07C31/22 , C07C47/19 , C07C59/10 , C12N9/0004 , C12N9/0006 , C12P7/18 , C12R1/07 , C12R1/145 , C12R1/19 , C12Y101/01001 , C12Y102/01003 , C12Y102/01004 , C12Y102/03001
Abstract: The present invention relates to a genetically modified microorganism for the production of 2,4-dihydroxybutyrate, by metabolic transformation of xylose via the 1,2,4-butanetriol intermediate. The invention also relates to a method for the production of 2,4-dihydroxybutyrate by culturing said genetically modified microorganism in a fermentation medium and recovering 2,4-DHB from said medium.
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9.发明申请公开(公告)号：US20170240938A1
公开(公告)日：2017-08-24
申请号：US15507435
申请日：2015-08-31
Applicant: METABOLIC EXPLORER
Inventor： Rainer FIGGE , Laurence DUMON-SEIGNOVERT , Perrine VASSEUR , Wanda DISCHERT
IPC: C12P13/12 , C07K14/245
CPC classification number: C12P13/12 , C07K14/245
Abstract: The present invention is related to a recombinant microorganism optimised for the fermentative production of methionine and/or its derivatives, wherein in said recombinant strain, the methionine efflux is enhanced by overexpressing the homologous logous genes of ygaZ and ygaH genes from Escherichia coli. It is also related to a method for optimising the fermentative production of methionine or its derivatives comprising the steps of: a. culturing a recombinant microorganism wherein in said microorganism, the methionine efflux is enhanced by overexpressing the ygaZH homologous genes of ygaZ and ygaH genes from Escherichia coli, in an appropriate culture medium comprising a fermentable source of carbon and a source of sulphur, and b. recovering methionine and/or its derivatives from the culture medium.
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