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1.发明授权公开(公告)号：US12016924B2
公开(公告)日：2024-06-25
申请号：US16564587
申请日：2019-09-09
申请人： MEDRX CO., LTD.
IPC分类号： A61K47/18 , A61K9/70 , A61K31/165 , A61K31/167 , A61K31/407 , A61K31/485 , A61K31/7088 , A61K38/23 , A61K47/14 , A61K47/32 , A61K47/38
CPC分类号： A61K47/18 , A61K9/7053 , A61K31/165 , A61K31/167 , A61K31/407 , A61K31/485 , A61K31/7088 , A61K38/23 , A61K47/14 , A61K47/32 , A61K47/38
摘要： A non-aqueous patch preparation may include a drug solution in which a drug is dissolved in an organic solvent, a lipophilic mass base, and anhydrous silicic acid powders that are insoluble both in the organic solvent and in the lipophilic mass base. The organic solvent is selected from the group consisting of propylene glycol, 1,3-butanediol, polyethylene glycol, and propylene carbonate. The lipophilic mass base comprises an elastomer, a tackifier, and a softening agent wherein the elastomer is styrene-isoprene-styrene copolymer (SIS). The patch preparation has 2% to 10% by weight of the anhydrous silicic acid powders.
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公开(公告)号：US20240108578A1
公开(公告)日：2024-04-04
申请号：US18276937
申请日：2022-02-10
申请人： MEDRx Co., Ltd.
摘要： The present invention provides a composition comprising an ionic liquid and a poorly absorbable drug, wherein the ionic liquid is prepared from an anion and a cation, the anion is an organic acid having 3 to 7 carbon atoms, and the cation is selected from the group consisting of arginine, meglumine, trometamol and diethanolamine, which remarkably improves the absorbability of the poorly absorbable drug.
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公开(公告)号：US11903939B2
公开(公告)日：2024-02-20
申请号：US16282215
申请日：2019-02-21
申请人： MEDRx Co., LTD
IPC分类号： A61K31/485 , A61K9/70 , A61F13/02 , A61F13/00 , A61K31/4468 , A61M35/00
CPC分类号： A61K31/485 , A61F13/00063 , A61F13/023 , A61F13/0289 , A61K9/7084 , A61K31/4468 , A61M2205/273
摘要： The present disclosure provides a patch preparation having features that prevent accidental use. In some embodiments, a patch preparation containing a plaster on a support, wherein the plaster comprises a solvent that is a combination of ethyl acetate and n-heptane. The patch preparation can lose its adhesion after the plaster is exposed to air and at least some of the solvent has evaporated, or if the patch is removed from the skin. This feature prevent the used patch from being applied to the skin again, and can prevent accidental use. A method of forming a patch preparation is also disclosed.
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公开(公告)号：US20230414912A1
公开(公告)日：2023-12-28
申请号：US18036637
申请日：2021-11-11
申请人： MEDRx Co., Ltd.
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0053
摘要： The present invention provides a microneedle array having microneedles coated with a composition comprising a poorly water-soluble or water-insoluble particle with a mean particle size of 1 μm or less, 2% to 20% by weight of a binding agent and 60% by weight or more of water in which the poorly water-soluble or water-insoluble particle is loaded on the microneedles in equal amounts that shows good puncturability.
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公开(公告)号：US20220370376A1
公开(公告)日：2022-11-24
申请号：US17769944
申请日：2020-10-14
申请人： MEDRX CO., LTD.
发明人： Yasushi Miwa , Hidetoshi Hamamoto
摘要： The present disclosure, for example, can include a laminated type patch A, comprising a release layer 1, a drug layer 2, a drug support layer 3 having elasticity, an adhesive layer 4, and an adhesive support layer 5 laminated in this order, wherein the outer edges of the release layer, the adhesive layer, and the adhesive support layer are all outside the outer edges of both the drug layer and the drug support layer; wherein the portion surrounded by the outer edges of the drug layer and the drug support layer, and the inner sides of the release layer and the adhesive layer has a space; and wherein the cross-sectional area of the space is 0.3 mm2 or more, at least when cut along the longitudinal centerline and the transverse centerline on the plane surfaces of the drug layer and the drug support layer.
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公开(公告)号：US11351348B2
公开(公告)日：2022-06-07
申请号：US16469137
申请日：2017-12-11
申请人： MEDRX CO., LTD
IPC分类号： A61M37/00
摘要： Provided are a method of applying a microneedle array, and a patch or an assistant tool used therefor. When skin is to be stretched and punctured with microneedles, the microneedle array can be prevented from detaching from the skin by providing adhesive layers, with the microneedle array therebetween, in a direction different from the direction in which the skin is stretched. Additionally, the application method can be appropriately implemented by producing a patch or an assistant tool having a rigid flat plate. As a result, the microneedle array can be punctured more accurately with less stress.
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公开(公告)号：US20220023423A1
公开(公告)日：2022-01-27
申请号：US17414026
申请日：2019-12-19
申请人： MEDRx Co., Ltd.
IPC分类号： A61K47/12 , A61K31/167 , A61K31/196 , A61K9/00 , A61K47/14 , A61K47/22 , A61K47/10
摘要： The present invention provides an external preparation composition comprising lactic acid salt of lidocaine consisting of lidocaine and a lactic acid ingredient and diclofenac or a salt thereof wherein the lactic acid ingredient is lactic acid and an alkali metal salt or alkaline earth metal salt of lactic acid, and an external preparation which exhibits higher transdermal absorbability of both lidocaine and diclofenac and the skin permeability suitable for clinical use, and enhances the storage stability and safety of the preparation to allow the long-term storage.
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公开(公告)号：US10932955B2
公开(公告)日：2021-03-02
申请号：US15774441
申请日：2016-11-09
申请人： MEDRX CO., LTD.
发明人： Hidetoshi Hamamoto
IPC分类号： A61F13/02 , A61K9/70 , A61F15/00 , A61F13/00 , B32B5/02 , B32B7/06 , B32B7/12 , B32B27/08 , B32B27/12
摘要： A percutaneous absorption agent delivery device with: a solvent-impermeable cover film that has a first layer and a second layer, which are integrally continuous via a first fold and are superimposed, a non-seal region and a seal region are formed between the first layer and the second layer, the non-seal region disposed along the first fold, the seal region to surround the outer peripheral section of the non-seal region except for the section along the first fold, and an endless cut portion forming the non-seal region formed in the cover film; a percutaneous absorption agent carrying member is disposed in the non-seal region between the first layer and the second layer, and fixed to the cover film on the inner side of the cut portion; and an adhesive sheet that is detachably affixed to the outer surface of the cover film.
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公开(公告)号：US20200171156A1
公开(公告)日：2020-06-04
申请号：US16782988
申请日：2020-02-05
申请人： MEDRx CO., LTD
发明人： Yasushi Miwa , Hidetoshi Hamamoto , Naoya Akazawa
IPC分类号： A61K47/12 , A61K31/433 , A61K31/485 , A61K9/70
摘要： The embodiments provide a percutaneous absorption composition for a basic medicament having improved transdermal absorbability. The percutaneous absorption composition comprises a sorbic acid and/or a metal sorbate as a percutaneous absorption promotor. The molar ration of the sorbic acid and/or the metal sorbate to the basic medicament is 0.5-2.5. The composition of the present disclosure may further comprise a basic component.
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公开(公告)号：US10556098B2
公开(公告)日：2020-02-11
申请号：US14424840
申请日：2013-08-30
申请人： TEIJIN LIMITED , MEDRX CO., LTD
摘要： The present disclosure relates to a microneedle array having a pin frog shape which is coated with a drug composition comprising a drug and an additive and having Vickers hardness of about 3 or more is applied to a microneedle array. The microneedle array coated with the drug composition according to the present invention can be used in the field in which the drug is required to be administered with high quantitative performance even when the drug is contained at low content.
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