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11 条记录 (耗时 0.02 秒)

    Reversibly bonded devices and methods of making and using the same
    2.
    发明授权
    Reversibly bonded devices and methods of making and using the same 有权

    公开(公告)号：US10737261B1

    公开(公告)日：2020-08-11

    申请号：US15719187

    申请日：2017-09-28

    申请人： Los Alamos National Security, LLC

    发明人： Pulak Nath ,  Jen-Huang Huang

    IPC分类号： B01L3/00 ,  G01N33/50

    摘要： The present disclosure concerns embodiments of reversibly bonded devices that comprise a reversible bonding component. The reversible bonding component is able to exhibit strong adhesive properties so as to couple device components, but upon exposure to an energy source, the strong adhesive properties are weakened. By weakening the adhesive strength of the reversible bonding component, the device can be deconstructed to access internal biological samples for analysis and characterization.

    SAMPLE PLATFORM AND METHODS OF USE
    6.
    发明申请
    SAMPLE PLATFORM AND METHODS OF USE 审中-公开
    样品平台和使用方法

    公开(公告)号：US20170059555A1

    公开(公告)日：2017-03-02

    申请号：US15252082

    申请日：2016-08-30

    申请人： Los Alamos National Security, LLC

    发明人： Rashi Iyer ,  Piyush Bajaj ,  Jen-Huang Huang

    IPC分类号： G01N33/50 ,  C12M1/34 ,  C12M1/32 ,  C12M1/42 ,  C12M3/00 ,  C12M1/12

    CPC分类号： G01N33/5005 ,  C12M23/12 ,  C12M23/42 ,  C12M25/04 ,  C12M35/00 ,  C12M35/08 ,  C12M41/46 ,  G01N2800/40

    摘要： Disclosed herein is a platform for holding a biological sample with a movable radiation source that can be used to expose the sample to controlled dosages of radiation in a targeted manner. In some embodiments, the platform includes a support structure and a cartridge for holding a sample. In some embodiments, the support structure includes a support for holding the sample, which may be in a well in the support structure. A radiation source can be adjusted relative to the sample (for example, the distance between the sample and the radiation source is controlled) in order to administer a particular dose of radiation to the sample.

    摘要翻译： 本文公开了一种用于保持具有可移动辐射源的生物样品的平台，其可以用于以目标方式将样品暴露于受控辐射剂量。 在一些实施例中，平台包括支撑结构和用于保持样品的盒。 在一些实施例中，支撑结构包括用于保持样品的支撑件，其可以在支撑结构中的井中。 可以相对于样品调节辐射源（例如，控制样品和辐射源之间的距离），以便向样品施加特定剂量的辐射。

    Microfluidic aspirator and methods of making and using the same
    9.
    发明授权
    Microfluidic aspirator and methods of making and using the same 有权

    公开(公告)号：US10408821B2

    公开(公告)日：2019-09-10

    申请号：US15488245

    申请日：2017-04-14

    申请人： Los Alamos National Security, LLC

    发明人： Pulak Nath ,  Jen-Huang Huang

    IPC分类号： C12M1/00 ,  C12M3/00 ,  G01N33/50 ,  C12N5/071 ,  C12M1/12

    摘要： Disclosed herein are devices that include a top chamber including at least one port, a bottom chamber including at least one inlet and at least one outlet, wherein the opening of the at least one inlet is smaller than the opening of the at least one outlet, and a membrane located between the top chamber and the bottom chamber, wherein the membrane is fluidly coupled with the top chamber and the bottom chamber. Also disclosed herein are systems including the disclosed devices. The systems include liquid in one or more of the chambers of the device. Methods of using the devices and systems include producing a vacuum by flowing a liquid through the bottom chamber of the system. Due to the difference in size of the inlet and outlet in the bottom chamber, a vacuum is produced in the top chamber.