公开(公告)号：US20190330608A1

公开(公告)日：2019-10-31

申请号：US16343069

申请日：2017-10-20

申请人： LYSANDO AG

发明人： Manfred BIEBL ,  Eva SCHIRMEIER ,  Martin GRIESSL

IPC分类号： C12N9/36 ,  A01N37/18

摘要： The present invention relates to the field of antimicrobial agents active against Enterococcus bacteria. In particular, the present invention relates to a polypeptide comprising a first and a second amino acid sequence, wherein the first amino acid sequence is a sequence selected from SEQ ID NO:2; SEQ ID NO:3; SEQ ID NO: 5; and derivatives thereof; and wherein the second amino acid sequence is an antimicrobial peptide, amphipathic peptide, cationic peptide, hydrophobic peptide, sushi peptide or defensin. In addition, the present invention relates to nucleic acids encoding such polypeptides, vectors comprising such nucleic acids, and corresponding host cells. Finally, the present invention relates to applications of the inventive polypeptides, nucleic acids, vectors, and/or host cells, in particular in the pharmaceutical field.

公开(公告)号：US20170051266A1

公开(公告)日：2017-02-23

申请号：US15118775

申请日：2015-02-13

申请人： Lysando AG

发明人： Yves BRIERS ,  Rob LAVIGNE ,  Martin GRIESSL

IPC分类号： C12N9/36 ,  C12N15/62 ,  C07K14/46 ,  A23K20/147 ,  C07K14/47 ,  A01N37/18 ,  A23L33/18 ,  C12N9/80 ,  C07K14/435

CPC分类号： C12N9/2462 ,  A01N37/18 ,  A23K20/147 ,  A23L33/18 ,  A23V2002/00 ,  A61K38/00 ,  C07K14/43563 ,  C07K14/43572 ,  C07K14/43577 ,  C07K14/461 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/55 ,  C07K2319/95 ,  C12N9/80 ,  C12N15/62 ,  C12Y302/01017 ,  C12Y305/01028

摘要： The present invention relates to polypeptides comprising an amino sequence selected from the group consisting of: SEQ ID NO: 1, and fragments and derivatives of these. The invention also relates to the corresponding nucleic acids vectors, host cells and compositions. The present inventions also relates to the use of said polypeptides, nucleic acids, vectors, host cells and compositions in a method for treatment of the human or animal body by surgery or therapy or in diagnostic methods practiced on the human or animal body, in particular for the treatment or prevention of Gram-negative bacterial infections. The polypeptides, nucleic acids, vectors, host cells and compositions according to the invention may also be used as an antimicrobial in food or feed, or in cosmetics, as disinfecting agent or in the environmental field.

摘要翻译： 本发明涉及包含选自SEQ ID NO：1的氨基酸序列的多肽，以及它们的片段和衍生物。 本发明还涉及相应的核酸载体，宿主细胞和组合物。 本发明还涉及通过手术或治疗或在人体或动物身上实施的诊断方法中所述多肽，核酸，载体，宿主细胞和组合物在用于治疗人或动物体的方法中的用途，特别是 用于治疗或预防革兰阴性细菌感染。 根据本发明的多肽，核酸，载体，宿主细胞和组合物也可以用作食品或饲料中的抗微生物剂，或在化妆品中用作消毒剂或在环境领域中。

公开(公告)号：US20210300979A1

公开(公告)日：2021-09-30

申请号：US17057933

申请日：2019-05-29

申请人： LYSANDO AG

发明人： Manfred BIEBL ,  Martin GRIESSL

IPC分类号： C07K14/47 ,  C12N9/36 ,  A01N63/50 ,  C07K14/435 ,  A61P31/04

摘要： The present invention relates to a polypeptide comprising a Gram negative endolysin and a peptide selected from the group consisting of an antimicrobial peptide, an amphipathic peptide, a cationic peptide, a sushi peptide or a defensin, wherein the endolysin in turn is selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9 and sequences having at least 80% sequence identity with SEQ ID NO:1, SEQ ID NO:2, SEQ ID NOG, SEQ ID NO:4, SEQ ID NOG, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8 and/or SEQ ID NO:9. The present invention relates also to corresponding nucleic acids, vectors, bacteriophages, host cells, compositions and kits. The present inventions also relates to the use of said polypeptides, nucleic acids, vectors, bacteriophages, host cells, compositions and kits in methods for treatment of the human or animal body by surgery or therapy or in diagnostic methods practiced on the human or animal body. The polypeptides, nucleic acids, vectors, bacteriophages, host cells, compositions and kits according to the invention may also be used as an antimicrobial in, e.g., food or feed, in cosmetics, or as disinfecting agent.

公开(公告)号：US20210198645A1

公开(公告)日：2021-07-01

申请号：US17057746

申请日：2019-05-29

申请人： LYSANDO AG

发明人： Manfred BIEBL ,  Martin GRIESSL

IPC分类号： C12N9/36 ,  C07K14/47 ,  A61L2/16 ,  C07K14/435

摘要： The present invention relates to a polypeptide comprising a Gram negative endolysin and a peptide selected from the group consisting of an antimicrobial peptide, an amphipathic peptide, a cationic peptide, a sushi peptide or a defensin, wherein the endolysin in turn is an endolysin comprising a sequence according to SEQ ID NO:1 or SEQ ID NO:2. The present invention relates also to corresponding nucleic acids, vectors, bacteriophages, host cells, compositions and kits. The present inventions also relates to the use of said polypeptides, nucleic acids, vectors, bacteriophages, host cells, compositions and kits in methods for treatment of the human or animal body by surgery or therapy or in diagnostic methods practiced on the human or animal body. The polypeptides, nucleic acids, vectors, bacteriophages, host cells, compositions and kits according to the invention may also be used as an antimicrobial in, e.g., food or feed, in cosmetics, or as disinfecting agent.

公开(公告)号：US20190125897A1

公开(公告)日：2019-05-02

申请号：US16097142

申请日：2017-04-28

申请人： LYSANDO AG

发明人： Martin GRIESSL ,  Manfred BIEBL ,  Eva SCHIRMEIER

IPC分类号： A61K48/00 ,  C07K14/46 ,  C12N15/62 ,  A61P31/04

摘要： The present invention relates to the field of antimicrobial agents active against Salmonella bacteria. In particular, the present invention relates to polypeptides comprising a first and a second amino acid sequence, wherein the first amino acid sequence is an endolysin, and wherein the second amino acid sequence is an antimicrobial peptide, cationic peptide, hydrophobic peptide, amphipathic peptide or sushi peptide, and wherein the polypeptide comprises at least one sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:4 and derivatives thereof. In addition, the present invention relates to nucleic acids encoding such polypeptides, vectors comprising such nucleic acids, and corresponding host cells. Finally, the present invention relates to applications of the inventive polypeptides, nucleic acids, vectors, and/or host cells, in particular in the pharmaceutical field and in the field of food and feed.