公开(公告)号：US20220096393A1

公开(公告)日：2022-03-31

申请号：US17295101

申请日：2019-11-20

申请人： LTS Lohmann Therapie-Systeme AG

发明人： Florian HAMMES ,  Anja TOMELERI ,  Tobias KLEUDGEN

IPC分类号： A61K9/70

摘要： The invention relates to a system containing: a transdermal therapeutic system (TTS); a cylindrical separating layer having an outer periphery and an inner periphery; and a backing layer, which is applied to the cylindrical separating layer and protrudes beyond the cylindrical separating layer over the entire periphery. The invention further relates to a system for improving the adhesion of a TTS, to the use of the system, and to a kit containing the system.

公开(公告)号：US20230285323A1

公开(公告)日：2023-09-14

申请号：US18019505

申请日：2021-07-22

申请人： LTS LOHMANN THERAPIE-SYSTEME AG

发明人： Florian HAMMES ,  Anja TOMELERI ,  Tobias KLEUDGEN

IPC分类号： A61K31/135 ,  A61K9/70 ,  A61K47/14 ,  A61K47/12 ,  A61K47/10

CPC分类号： A61K31/135 ,  A61K9/7069 ,  A61K47/14 ,  A61K47/12 ,  A61K47/10

摘要： The present invention concerns a transdermal therapeutic system, comprising a backing layer, which is not permeable N for the active ingredient, and at least one matrix layer on one side of the backing layer, wherein the matrix layer contains at least one pressure sensitive adhesive and ketamine or a pharmaceutically acceptable salt or solvate thereof, wherein the at least one pressure sensitive adhesive comprises a silicone pressure sensitive adhesive, as well as its use as medicament, in particular for the treatment of depression and pain.

公开(公告)号：US20220160646A1

公开(公告)日：2022-05-26

申请号：US17522200

申请日：2021-11-09

申请人： LTS LOHMANN THERAPIE-SYSTEME AG

发明人： Markus MÜLLER ,  Mario FICKER ,  Michael LINN ,  Florian HAMMES

IPC分类号： A61K9/70 ,  A61K47/32 ,  A61K31/135

摘要： Described is an oral thin film comprising at least one matrix layer, wherein the at least one matrix layer comprises at least one pharmaceutically active agent, at least one polyvinyl alcohol and at least one polyvinyl alcohol-polyethylene glycol graft copolymer, a method for producing same, and use thereof as a medicament.

公开(公告)号：US20230233480A1

公开(公告)日：2023-07-27

申请号：US17769548

申请日：2020-10-21

申请人： LTS LOHMANN THERAPIE-SYSTEME AG

发明人： Florian HAMMES ,  Anja TOMELERI ,  Tobias KLEUDGEN

IPC分类号： A61K9/70 ,  A61K31/137 ,  A61K47/38 ,  A61K47/10 ,  A61K47/34 ,  A61K47/32 ,  A61F13/15

CPC分类号： A61K9/7084 ,  A61K31/137 ,  A61K47/38 ,  A61K47/10 ,  A61K47/34 ,  A61K47/32 ,  A61F13/15 ,  A61F2013/0296

摘要： The present invention relates to transdermal therapeutic systems (TTS) for the transdermal administration of fingolimod.

公开(公告)号：US20220265568A1

公开(公告)日：2022-08-25

申请号：US17631629

申请日：2020-07-28

申请人： LTS LOHMANN THERAPIE-SYSTEME AG

发明人： Michael ORTH ,  Tobias TELLKAMP-SCHEHR ,  Florian HAMMES ,  Julia LODDER-GADACZEK

IPC分类号： A61K9/70 ,  A61K31/137 ,  A61K45/06

摘要： The invention relates to a process for preparing an active-principle-containing adhesive formulation for use in a transdermal therapeutic system, comprising the following steps: a) providing an adhesive formulation containing a carboxylic acid ester-based solvent and a self-adhesive polymer matrix containing monomers of the compounds on which the polymer matrix is based, b) removing the carboxylic acid ester-based solvent and the monomers from the adhesive formulation, c) re-dissolving the compound obtained in step b) in an organic solvent that does not contain any ester groups, and adding a pharmacologically active principle having at least one hydroxyl group, carboxyl group, amino group and/or ester group so that the active-principle-containing adhesive formulation is obtained. The invention also relates to a transdermal therapeutic system containing the active-principle-containing adhesive formulation. The invention further relates to the use of said transdermal therapeutic system and to a kit containing the transdermal therapeutic system.

公开(公告)号：US20230381116A1

公开(公告)日：2023-11-30

申请号：US18446645

申请日：2023-08-09

申请人： LTS Lohmann Therapie-Systeme AG

发明人： Florian HAMMES ,  René EIFLER

IPC分类号： A61K9/70 ,  A61K9/00 ,  A61K31/485

CPC分类号： A61K9/7061 ,  A61K9/0014 ,  A61K31/485

摘要： The invention relates to systems formed from closed liquid-tight packaging and a preferably dimensionally stable aqueous composition which is sealed therein and which, upon activation, releases a liquid phase essentially composed of water in a time-delayed manner. The invention further relates to methods for manufacturing such systems and the use thereof during the production of self-decomposing transdermal therapeutic systems (TTS).

公开(公告)号：US20220241218A1

公开(公告)日：2022-08-04

申请号：US17603885

申请日：2020-04-17

申请人： LTS LOHMANN THERAPIE-SYSTEME AG

发明人： Florian HAMMES ,  Tobias KLEUDGEN ,  Anja TOMELERI

IPC分类号： A61K31/135 ,  A61K9/70

摘要： The present invention concerns a transdermal therapeutic system, comprising a backing layer, which is not permeable for the active ingredient, and a matrix layer on one side of the backing layer, wherein the matrix layer contains at least one pressure sensitive adhesive and ketamine or a pharmaceutically acceptable salt or solvate thereof, wherein the at least one pressure sensitive adhesive has free hydroxyl groups, as well as its use as medicament, in particular for the treatment of depression and pain.