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![NEW PROCESS FOR THE RESOLUTION OF ENANTIOMERS OF (3,4 DIMETHOXY-BICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL)NITRILE AND APPLICATION IN THE SYNTHESIS OF IVABRADINE](/abs-image/US/2013/08/15/US20130211070A1/abs.jpg.150x150.jpg)
1.发明申请NEW PROCESS FOR THE RESOLUTION OF ENANTIOMERS OF (3,4 DIMETHOXY-BICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL)NITRILE AND APPLICATION IN THE SYNTHESIS OF IVABRADINE 有权（3,4二甲基 - 二苯甲酮[4.2.0] OCTA-1,3,5-三烯-7-YL）衍生物的合成新方法及其在合成IVABRADINE中的应用公开(公告)号：US20130211070A1
公开(公告)日：2013-08-15
申请号：US13850514
申请日：2013-03-26
Applicant: LES LABORATOIRES SERVIER
Inventor： Jean-Michel LERESTIF , Jean-Pierre LECOUVE , Daniel DRON , Eric GOJON , Maryse PHAN
IPC: C07C253/30 , C07D223/10
CPC classification number: C07C253/30 , C07C209/48 , C07C255/47 , C07D223/10 , C07D223/16
Abstract: Process for the optical resolution of the compound of formula (I): by chiral chromatography.Application in the synthesis of ivabradine, of its addition salts with a pharmaceutically acceptable acid and of their hydrates.
Abstract translation: 式（I）化合物的光学拆分方法：用手性色谱法。 应用于伊伐布雷定的合成，其与药学上可接受的酸及其水合物的加成盐。
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公开(公告)号：US20160368859A1
公开(公告)日：2016-12-22
申请号：US15100782
申请日：2014-12-04
Applicant: LES LABORATOIRES SERVIER
Inventor： Jean-François BRIERE , Raphaël LEBEUF , Vincent LEVACHER , Christophe HARDOUIN , Jean-Pierre LECOUVE
IPC: C07C231/12 , C07C303/28 , C07C231/06 , C07C309/66 , C07C309/73
CPC classification number: C07C231/12 , C07C41/16 , C07C41/18 , C07C41/26 , C07C41/32 , C07C43/23 , C07C45/30 , C07C213/02 , C07C217/58 , C07C217/60 , C07C231/02 , C07C231/06 , C07C231/065 , C07C231/10 , C07C235/34 , C07C253/30 , C07C303/28 , C07C303/30 , C07C309/65 , C07C309/66 , C07C309/73 , C07D307/92 , C07C255/37 , C07C233/18 , C07C43/215 , C07C47/277
Abstract: Process for the industrial synthesis of the compound of formula (I):
Abstract translation: 本发明涉及一种用于工业合成式（I）化合物的方法。
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3.发明申请SYNTHESIS PROCESS, AND CRYSTALLINE FORM OF 4-{3[CIS-HEXAHYDROCYCLOPENT A[CjPYRROL-2( 1 H)-YLjPROPOXYj BENZAMI DE HYDROCHLORI DE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT 审中-公开合成方法和4- {3 [联苯二甲酰氯[A]吡啶-2-（1H） - 吡啶并[b]]]]]] IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT公开(公告)号：US20140155453A1
公开(公告)日：2014-06-05
申请号：US14174272
申请日：2014-02-06
Applicant: LES LABORATOIRES SERVIER
Inventor： Nicolas ROBERT , Jean-Michel LERESTIF , Jean-Pierre LECOUVE , Marina GAILLARD , Loic MEUNIER , Philippe LETELLIER , Mathieu BOIRET
IPC: C07D209/52
CPC classification number: C07C309/63 , C07B2200/13 , C07C235/46 , C07D209/52 , C07D317/22 , C07D319/06
Abstract: Medicinal products containing the crystalline form I of the compound of formula (I): and/or crystalline form I of the associated free base which are useful in the treatment of disorders of the histaminergic system.
Abstract translation: 含有式（I）化合物的结晶形式I的药用产品：和/或可用于治疗组胺能系统疾病的相关游离碱的结晶形式I.
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