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![NEW PROCESS FOR THE RESOLUTION OF ENANTIOMERS OF (3,4 DIMETHOXY-BICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL)NITRILE AND APPLICATION IN THE SYNTHESIS OF IVABRADINE](/abs-image/US/2013/08/15/US20130211070A1/abs.jpg.150x150.jpg)
1.发明申请NEW PROCESS FOR THE RESOLUTION OF ENANTIOMERS OF (3,4 DIMETHOXY-BICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL)NITRILE AND APPLICATION IN THE SYNTHESIS OF IVABRADINE 有权（3,4二甲基 - 二苯甲酮[4.2.0] OCTA-1,3,5-三烯-7-YL）衍生物的合成新方法及其在合成IVABRADINE中的应用公开(公告)号：US20130211070A1
公开(公告)日：2013-08-15
申请号：US13850514
申请日：2013-03-26
Applicant: LES LABORATOIRES SERVIER
Inventor： Jean-Michel LERESTIF , Jean-Pierre LECOUVE , Daniel DRON , Eric GOJON , Maryse PHAN
IPC: C07C253/30 , C07D223/10
CPC classification number: C07C253/30 , C07C209/48 , C07C255/47 , C07D223/10 , C07D223/16
Abstract: Process for the optical resolution of the compound of formula (I): by chiral chromatography.Application in the synthesis of ivabradine, of its addition salts with a pharmaceutically acceptable acid and of their hydrates.
Abstract translation: 式（I）化合物的光学拆分方法：用手性色谱法。 应用于伊伐布雷定的合成，其与药学上可接受的酸及其水合物的加成盐。
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