公开(公告)号：US20170025265A1

公开(公告)日：2017-01-26

申请号：US15301249

申请日：2015-03-31

Applicant: LECO Corporation

Inventor： Anatoly N. VERENCHIKOV ,  Aleksey VOROBYEV

IPC: H01J49/40 ,  G01T1/20

CPC classification number: H01J49/406 ,  G01T1/20 ,  H01J49/025

Abstract: There is proposed a right angle time-of-flight detector (41, 117, 124, 143, 144, 145) comprising a conductive converter (46) for emitting and accelerating secondary electrons, a magnetic field formed by at least one magnet (47) for deflecting the secondary electrons at a right angle and a sealed photo-multiplier (26). The detector is expected to provide an extended resource and dynamic range and may be fit into tight assemblies, such as MR-TOF MS.

Abstract translation: 提出了包括用于发射和加速二次电子的导电转换器（46）的直角飞行时间检测器（41,117,124,143,144,145），由至少一个磁体（47）形成的磁场 ），用于以直角偏转二次电子和密封的光电倍增器（26）。 检测器预计将提供扩展的资源和动态范围，并且可以适合于诸如MR-TOF MS之类的紧密组件。

公开(公告)号：US20170278688A1

公开(公告)日：2017-09-28

申请号：US15508800

申请日：2015-09-04

Applicant: LECO CORPORATION

Inventor： Anatoly N. VERENCHIKOV ,  Alexander KOLOSOV

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/10

CPC classification number: H01J49/0031 ,  G01N2030/8482 ,  H01J49/0036 ,  H01J49/0418 ,  H01J49/102 ,  H01J49/145

Abstract: One aspect of the disclosure provides a method of mass spectrometric analysis that includes producing either glow discharge within a noble gas between 3-100 mBar pressure, sampling and conditioning glow discharge products within a gas flow through a conductive channel, removing charged particles while transferring excited Ridberg atoms, and mixing conditioned discharge products with analyte flow within an enclosed chamber at elevated temperatures above 150° Celsius for producing a Penning reaction between analyte molecules and Ridberg atoms. The method further includes sampling, by a gas flow, said analyte ions for mass spectrometric analysis, and at least one of the following steps: (i) removing charge within said conditioning channel; (ii) coaxially mixing of analyte flow with the flow of conditioned plasma; and (iii) cooling of the mixed flow within a sonic or supersonic jet for reducing the region of Penning ionization to cold jet.

公开(公告)号：US20170016863A1

公开(公告)日：2017-01-19

申请号：US15301129

申请日：2014-10-23

Applicant: LECO Corporation

Inventor： Anatoly N. VERENCHIKOV

IPC: G01N30/72 ,  H01J49/00 ,  H01J49/14 ,  H01J49/40

CPC classification number: G01N30/7206 ,  H01J49/0031 ,  H01J49/147 ,  H01J49/401 ,  H01J49/406

Abstract: A method of targeted mass spectrometric analysis is provided for analyzing trace compounds at sub-ppb level compared to sample matrix. Sample is chromatographically separated at standard conditions to employ a map of target mass (M) versus retention time (RT). Small mass ions under M(RT) are rejected by RF field, and remaining ions are accumulated for pulsed injection into a multi-reflecting TOF MS, either directly from EI source, or from linear RF trap or via a heated RF only quadrupole with axial ion trapping. In combination with EI source the method provides sub femtogram sensitivity at matrices loads in microgram range.

Abstract translation: 提供了一种靶向质谱分析方法，用于分析与样品基质相比亚ppb级别的痕量化合物。 样品在标准条件下进行色谱分离，以使用目标质量（M）与保留时间（RT）的对照。 在M（RT）下的小质量离子被RF场排斥，并且剩余的离子被累积用于脉冲注入到多反射TOF MS中，直接来自EI源，或者来自线性RF陷阱，或者通过加热的RF仅四极杆轴向 离子捕获。 与EI源组合，该方法在微克范围内的矩阵载荷下提供副飞镖敏感度。