公开(公告)号：US20190117599A1

公开(公告)日：2019-04-25

申请号：US16172208

申请日：2018-10-26

申请人： LAURENT PHARMACEUTICALS

发明人： Aimesther BETANCOURT ,  Marc LEMIEUX ,  Roch THIBERT

IPC分类号： A61K31/167 ,  A61K9/20 ,  A61K9/48

CPC分类号： A61K31/167 ,  A61K9/146 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2095 ,  A61K9/4808 ,  A61K9/4833 ,  A61K9/4858 ,  A61K9/4866 ,  A61K9/5084

摘要： Amorphous solid dispersions suitable for oral delivery comprising fenretinide or an analog thereof and at least one matrix polymer, and processes for making the dispersions, are disclosed. Also disclosed are solid oral formulations comprising the amorphous solid dispersions, as well as uses thereof for the prevention and/or treatment of diseases or conditions treatable by fenretinide, including but not limited to cancers, conditions associated with a lipid imbalance, cystic fibrosis, osteoporosis, conditions associated with inflammation or opportunistic infections, and other diseases such as diabetes, obesity, dry-form age-related macular degeneration.

公开(公告)号：US20170189356A1

公开(公告)日：2017-07-06

申请号：US15328381

申请日：2015-07-24

申请人： LAURENT PHARMACEUTICALS

发明人： Aimesther BETANCOURT ,  Marc LEMIEUX ,  Roch THIBERT

IPC分类号： A61K31/167 ,  A61K9/20 ,  A61K9/48

CPC分类号： A61K31/167 ,  A61K9/146 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2095 ,  A61K9/4808 ,  A61K9/4833 ,  A61K9/4858 ,  A61K9/4866

摘要： Amorphous solid dispersions suitable for oral delivery comprising fenretinide or an analog thereof and at least one matrix polymer, and processes for making the dispersions, are disclosed. Also disclosed are solid oral formulations comprising the amorphous solid dispersions, as well as uses thereof for the prevention and/or treatment of diseases or conditions treatable by fenretinide, including but not limited to cancers, conditions associated with a lipid imbalance, cystic fibrosis, osteoporosis, conditions associated with inflammation or opportunistic infections, and other diseases such as diabetes, obesity, dry-form age-related macular degeneration.