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    Monopartite RNA virus transformation vectors
    2.
    发明申请
    Monopartite RNA virus transformation vectors 审中-公开
    单分子RNA病毒转化载体

    公开(公告)号：US20030150019A1

    公开(公告)日：2003-08-07

    申请号：US10280679

    申请日：2002-10-24

    申请人： LARGE SCALE BIOLOGY CORPORATION

    发明人： Thomas H. Turpen ,  Ann Myers Turpen ,  Stephen J. Garger ,  Laurence K. Grill ,  Jonathan Donson ,  William O. Dawson ,  George L. Granthan

    IPC分类号： A01H001/00 ,  C12N015/82 ,  C12N007/00

    CPC分类号： C12Y114/18001 ,  C07K14/005 ,  C07K14/415 ,  C12N9/0059 ,  C12N9/0071 ,  C12N9/1074 ,  C12N9/14 ,  C12N9/16 ,  C12N9/18 ,  C12N9/20 ,  C12N9/6459 ,  C12N9/78 ,  C12N9/84 ,  C12N15/8203 ,  C12N15/86 ,  C12N2770/00022 ,  C12N2770/36122 ,  C12N2830/00 ,  C12N2830/60 ,  C12P41/003 ,  C12Y301/11002 ,  C12Y302/01031 ,  C12Y304/21069

    摘要： The present invention relates to a recombinant viral nucleic acid selected from a (null) sense, single stranded RNA virus possessing a native subgenomic promoter encoding for a first viral subgenomic promoter, a nucleic acid sequence that codes for a viral coat protein whose transcription is regulated by the first viral subgenomic promoter, a second viral subgenomic promoter and a second nucleic acid sequence whose transcription is regulated by the second viral subgenomic promoter. The first and second viral subgenomic promoters of the recombinant viral nucleic acid do not have homologous sequences relative to each other. The recombinant viral nucleic acid provides the particular adivantage that it systemically transcribes the second nucleic acid in the host. Host organisms encompassed by the present invention include procaryotes and eucaryotes, particularly animals and plants. The present invention also relates to viruses containing the viral vectors which are infective, production cells which are capable of producing the viruses or parts thereof, a host infected by the viruses of the invention, the gene products produced by expression of the viral nucleic acids and a process for the production of a desired product by growing the infected hosts.

    摘要翻译： 本发明涉及选自具有编码第一病毒亚基因组启动子的天然亚基因启动子的（+）有义单链RNA病毒的重组病毒核酸，编码转录调节的病毒外壳蛋白的核酸序列 通过第一病毒亚基因组启动子，第二病毒亚基因组启动子和其转录受第二病毒亚基因组启动子调控的第二核酸序列。 重组病毒核酸的第一和第二病毒亚基因组启动子相对于彼此不具有同源序列。 重组病毒核酸提供其系统地转录宿主中的第二核酸的特别优点。 本发明包括的宿主生物包括原核生物和真核生物，特别是动物和植物。 本发明还涉及含有感染性病毒载体的病毒，能够产生病毒或其部分的生产细胞，被本发明的病毒感染的宿主，通过表达病毒核酸产生的基因产物和 通过生长受感染的宿主来生产所需产品的方法。