公开(公告)号：US20240166641A1

公开(公告)日：2024-05-23

申请号：US18463134

申请日：2023-09-07

Applicant: Kumquat Biosciences Inc.

Inventor： Liansheng Li ,  Xiuwen Zhu ,  Pingda Ren ,  Jonathan Deane ,  Lomon So ,  Yi Liu

IPC: C07D417/14 ,  A61P35/00 ,  C07D417/04 ,  C07D471/04

CPC classification number: C07D417/14 ,  A61P35/00 ,  C07D417/04 ,  C07D471/04

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salt thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US20240425525A1

公开(公告)日：2024-12-26

申请号：US18787939

申请日：2024-07-29

Applicant: Kumquat Biosciences Inc.

Inventor： Pingda Ren ,  Liansheng Li ,  Baogen Wu ,  Xiaoming Li ,  Zhiyong Chen ,  Siling Zhao ,  Yi Liu ,  Xiuwen Zhu

IPC: C07D519/00 ,  A61K31/519 ,  A61K31/551 ,  A61K31/553

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US20240254129A1

公开(公告)日：2024-08-01

申请号：US18446017

申请日：2023-08-08

Applicant: Kumquat Biosciences Inc.

Inventor： Liansheng Li ,  Xiuwen Zhu ,  Zhimin Zhu ,  Pingda Ren ,  Yuan Liu ,  Yi Liu

IPC: C07D487/04 ,  A61P35/00 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/08 ,  C07D487/10 ,  C07D491/048 ,  C07D519/00

CPC classification number: C07D487/04 ,  A61P35/00 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/08 ,  C07D487/10 ,  C07D491/048 ,  C07D519/00

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salt thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US20240425522A1

公开(公告)日：2024-12-26

申请号：US18668025

申请日：2024-05-17

Applicant: Kumquat Biosciences Inc.

Inventor： Pingda Ren ,  Liansheng Li ,  Baogen Wu ,  Xiaoming Li ,  Zhiyong Chen ,  Siling Zhao ,  Yi Liu ,  Xiuwen Zhu

IPC: C07D519/00 ,  A61K31/519 ,  A61K31/551 ,  A61K31/553

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US20240398828A1

公开(公告)日：2024-12-05

申请号：US18669349

申请日：2024-05-20

Applicant: Kumquat Biosciences Inc.

Inventor： Liansheng Li ,  Xiuwen Zhu ,  Pingda Ren ,  Jonathan Deane ,  Lomon So ,  Yi Liu

IPC: A61K31/553 ,  A61K31/433 ,  A61K31/437 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K45/06 ,  A61P37/04 ,  C07D285/06 ,  C07D417/10 ,  C07D417/14 ,  C07D471/08 ,  C07D487/10 ,  C07D491/107

Abstract: The present disclosure provides compounds and pharmaceutical compositions comprising the same. The compounds, pharmaceutical compositions thereof, and methods of using the same have a range of utilities as therapeutics, diagnostics, and research tools. The subject compositions and methods are particularly useful for potentiating immune response and/or applicable for treating cancer and other diseases.

公开(公告)号：US12209102B2

公开(公告)日：2025-01-28

申请号：US18668025

申请日：2024-05-17

Applicant: Kumquat Biosciences Inc.

Inventor： Pingda Ren ,  Liansheng Li ,  Baogen Wu ,  Xiaoming Li ,  Zhiyong Chen ,  Siling Zhao ,  Yi Liu ,  Xiuwen Zhu

IPC: C07D519/00 ,  A61K31/519 ,  A61K31/551 ,  A61K31/553

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US20240383888A1

公开(公告)日：2024-11-21

申请号：US18778527

申请日：2024-07-19

Applicant: Kumquat Biosciences Inc.

Inventor： Yi Liu ,  Pingda Ren ,  Liansheng Li ,  Zhimin Zhu ,  Xiuwen Zhu

IPC: C07D417/14 ,  A61P35/00 ,  C07D487/04 ,  C07D519/00

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salt thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US20240270736A1

公开(公告)日：2024-08-15

申请号：US18521254

申请日：2023-11-28

Applicant: Kumquat Biosciences Inc.

Inventor： Baogen Wu ,  Liansheng Li ,  Pingda Ren ,  Zhiyong Chen ,  Siling Zhao ,  Xiuwen Zhu

IPC: C07D417/12 ,  A61K45/06 ,  C07C235/88 ,  C07D207/16 ,  C07D209/18 ,  C07D241/44 ,  C07D401/04 ,  C07D403/06 ,  C07D493/06

CPC classification number: C07D417/12 ,  A61K45/06 ,  C07C235/88 ,  C07D207/16 ,  C07D209/18 ,  C07D241/44 ,  C07D401/04 ,  C07D403/06 ,  C07D493/06

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US20230331717A1

公开(公告)日：2023-10-19

申请号：US18175349

申请日：2023-02-27

Applicant: Kumquat Biosciences Inc.

Inventor： Yi Liu ,  Pingda Ren ,  Liansheng Li ,  Zhimin Zhu ,  Xiuwen Zhu

IPC: C07D417/14 ,  C07D487/04 ,  C07D519/00 ,  A61P35/00

CPC classification number: C07D417/14 ,  C07D487/04 ,  C07D519/00 ,  A61P35/00

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salt thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.