公开(公告)号：US12195465B2

公开(公告)日：2025-01-14

申请号：US18497515

申请日：2023-10-30

Applicant: Kumquat Biosciences Inc.

Inventor： Baogen Wu ,  Pingda Ren ,  Zhiyong Chen ,  Yi Liu

IPC: C07D471/22 ,  A61K45/06 ,  C07D495/22 ,  C07D498/22

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salt thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US20240166641A1

公开(公告)日：2024-05-23

申请号：US18463134

申请日：2023-09-07

Applicant: Kumquat Biosciences Inc.

Inventor： Liansheng Li ,  Xiuwen Zhu ,  Pingda Ren ,  Jonathan Deane ,  Lomon So ,  Yi Liu

IPC: C07D417/14 ,  A61P35/00 ,  C07D417/04 ,  C07D471/04

CPC classification number: C07D417/14 ,  A61P35/00 ,  C07D417/04 ,  C07D471/04

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salt thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US20240109918A1

公开(公告)日：2024-04-04

申请号：US18311853

申请日：2023-05-03

Applicant: Kumquat Biosciences Inc.

Inventor： Xiaoming Li ,  Yuan Liu ,  Pingda Ren ,  Liansheng Li ,  Zhiyong Chen ,  Baogen Wu ,  Siling Zhao

IPC: C07D519/00 ,  A61P35/00 ,  C07D471/10 ,  C07D487/10

CPC classification number: C07D519/00 ,  A61P35/00 ,  C07D471/10 ,  C07D487/10

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US11912708B2

公开(公告)日：2024-02-27

申请号：US18328109

申请日：2023-06-02

Applicant: Kumquat Biosciences Inc.

Inventor： Baogen Wu ,  Pingda Ren ,  Zhiyong Chen ,  Yi Liu

IPC: C07D471/22 ,  A61K45/06 ,  C07D495/22 ,  C07D498/22

CPC classification number: C07D471/22 ,  A61K45/06 ,  C07D495/22 ,  C07D498/22

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salt thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US20240425522A1

公开(公告)日：2024-12-26

申请号：US18668025

申请日：2024-05-17

Applicant: Kumquat Biosciences Inc.

Inventor： Pingda Ren ,  Liansheng Li ,  Baogen Wu ,  Xiaoming Li ,  Zhiyong Chen ,  Siling Zhao ,  Yi Liu ,  Xiuwen Zhu

IPC: C07D519/00 ,  A61K31/519 ,  A61K31/551 ,  A61K31/553

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US20240398828A1

公开(公告)日：2024-12-05

申请号：US18669349

申请日：2024-05-20

Applicant: Kumquat Biosciences Inc.

Inventor： Liansheng Li ,  Xiuwen Zhu ,  Pingda Ren ,  Jonathan Deane ,  Lomon So ,  Yi Liu

IPC: A61K31/553 ,  A61K31/433 ,  A61K31/437 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K45/06 ,  A61P37/04 ,  C07D285/06 ,  C07D417/10 ,  C07D417/14 ,  C07D471/08 ,  C07D487/10 ,  C07D491/107

Abstract: The present disclosure provides compounds and pharmaceutical compositions comprising the same. The compounds, pharmaceutical compositions thereof, and methods of using the same have a range of utilities as therapeutics, diagnostics, and research tools. The subject compositions and methods are particularly useful for potentiating immune response and/or applicable for treating cancer and other diseases.

公开(公告)号：US20240390389A1

公开(公告)日：2024-11-28

申请号：US18634495

申请日：2024-04-12

Applicant: Kumquat Biosciences Inc.

Inventor： Baogen Wu ,  Liansheng Li ,  Pingda Ren ,  Yi Liu ,  Siling Zhao ,  Xiaoming Li ,  Zhiyong Chen ,  Zhimin Zhu

IPC: A61K31/553 ,  A61K31/519 ,  A61P35/00 ,  C07D519/00

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of certain oncogenic proteins.

公开(公告)号：US20240208975A1

公开(公告)日：2024-06-27

申请号：US18497515

申请日：2023-10-30

Applicant: Kumquat Biosciences Inc.

Inventor： Baogen Wu ,  Pingda Ren ,  Zhiyong Chen ,  Yi Liu

IPC: C07D471/22 ,  A61K45/06 ,  C07D495/22 ,  C07D498/22

CPC classification number: C07D471/22 ,  A61K45/06 ,  C07D495/22 ,  C07D498/22

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salt thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US20230092294A1

公开(公告)日：2023-03-23

申请号：US17838068

申请日：2022-06-10

Applicant: Kumquat Biosciences Inc.

Inventor： Yi Liu ,  Jonathan Deane ,  Amy Strasner ,  Matthew R. Janes ,  Liansheng Li ,  Karen K. Wong ,  Pingda Ren

IPC: A61K38/17 ,  A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  A61K45/06

Abstract: The present disclosure provides compositions and methods for enhancing immunity (or immune response). The compositions and methods are particularly useful for potentiating immune response of a lymphoid cell. The compositions and methods are applicable for treating cancer and other diseases.

公开(公告)号：US20230044323A1

公开(公告)日：2023-02-09

申请号：US17838064

申请日：2022-06-10

Applicant: Kumquat Biosciences Inc.

Inventor： Yi Liu ,  Jonathan Deane ,  Amy Strasner ,  Liansheng Li ,  Matthew R. Janes ,  Karen K. Wong ,  Pingda Ren

IPC: A61K39/395 ,  A61K38/17 ,  A61K35/17 ,  A61K45/06 ,  A61P35/00

Abstract: The present disclosure provides compositions and methods for enhancing immunity (or immune response). The compositions and methods are particularly useful for potentiating immune response of a lymphoid cell. The compositions and methods are also applicable for treating cancer and other diseases.