公开(公告)号：US20240109918A1

公开(公告)日：2024-04-04

申请号：US18311853

申请日：2023-05-03

Applicant: Kumquat Biosciences Inc.

Inventor： Xiaoming Li ,  Yuan Liu ,  Pingda Ren ,  Liansheng Li ,  Zhiyong Chen ,  Baogen Wu ,  Siling Zhao

IPC: C07D519/00 ,  A61P35/00 ,  C07D471/10 ,  C07D487/10

CPC classification number: C07D519/00 ,  A61P35/00 ,  C07D471/10 ,  C07D487/10

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US20240425522A1

公开(公告)日：2024-12-26

申请号：US18668025

申请日：2024-05-17

Applicant: Kumquat Biosciences Inc.

Inventor： Pingda Ren ,  Liansheng Li ,  Baogen Wu ,  Xiaoming Li ,  Zhiyong Chen ,  Siling Zhao ,  Yi Liu ,  Xiuwen Zhu

IPC: C07D519/00 ,  A61K31/519 ,  A61K31/551 ,  A61K31/553

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US20240390389A1

公开(公告)日：2024-11-28

申请号：US18634495

申请日：2024-04-12

Applicant: Kumquat Biosciences Inc.

Inventor： Baogen Wu ,  Liansheng Li ,  Pingda Ren ,  Yi Liu ,  Siling Zhao ,  Xiaoming Li ,  Zhiyong Chen ,  Zhimin Zhu

IPC: A61K31/553 ,  A61K31/519 ,  A61P35/00 ,  C07D519/00

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of certain oncogenic proteins.

公开(公告)号：US20240425525A1

公开(公告)日：2024-12-26

申请号：US18787939

申请日：2024-07-29

Applicant: Kumquat Biosciences Inc.

Inventor： Pingda Ren ,  Liansheng Li ,  Baogen Wu ,  Xiaoming Li ,  Zhiyong Chen ,  Siling Zhao ,  Yi Liu ,  Xiuwen Zhu

IPC: C07D519/00 ,  A61K31/519 ,  A61K31/551 ,  A61K31/553

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US20240368191A1

公开(公告)日：2024-11-07

申请号：US18506478

申请日：2023-11-10

Applicant: Kumquat Biosciences Inc.

Inventor： Xiaoming Li ,  Liansheng Li ,  Baogen Wu ,  Yuan Liu ,  Rasmus Hansen ,  Zhiyong Chen ,  Pingda Ren

IPC: C07D519/00 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5383 ,  A61K31/5386 ,  A61K31/55 ,  A61K31/551 ,  A61K31/553 ,  C07D487/04 ,  C07D498/10

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US20240116951A1

公开(公告)日：2024-04-11

申请号：US18311850

申请日：2023-05-03

Applicant: Kumquat Biosciences Inc.

Inventor： Xiaoming Li ,  Yuan Liu ,  Pingda Ren ,  Liansheng Li

IPC: C07D519/00 ,  A61P35/00 ,  C07D471/10 ,  C07D487/10

CPC classification number: C07D519/00 ,  A61P35/00 ,  C07D471/10 ,  C07D487/10

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US11648254B2

公开(公告)日：2023-05-16

申请号：US17685370

申请日：2022-03-02

Applicant: Kumquat Biosciences Inc.

Inventor： Baogen Wu ,  Xiangzhu Wang ,  Xiaoming Li ,  Zhiyong Chen ,  Pingda Ren ,  Yi Liu

IPC: A61K31/519 ,  C07D487/04 ,  C07D471/04 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/506 ,  A61P35/00 ,  A61K31/541

CPC classification number: A61K31/519 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04

Abstract: The present disclosure provides compounds represented by Formula (I-1):




and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US12209102B2

公开(公告)日：2025-01-28

申请号：US18668025

申请日：2024-05-17

Applicant: Kumquat Biosciences Inc.

Inventor： Pingda Ren ,  Liansheng Li ,  Baogen Wu ,  Xiaoming Li ,  Zhiyong Chen ,  Siling Zhao ,  Yi Liu ,  Xiuwen Zhu

IPC: C07D519/00 ,  A61K31/519 ,  A61K31/551 ,  A61K31/553

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

公开(公告)号：US12059425B2

公开(公告)日：2024-08-13

申请号：US18439666

申请日：2024-02-12

Applicant: Kumquat Biosciences Inc.

Inventor： Baogen Wu ,  Liansheng Li ,  Pingda Ren ,  Yi Liu ,  Siling Zhao ,  Xiaoming Li ,  Zhiyong Chen ,  Zhimin Zhu

IPC: A61K31/553 ,  A61K31/519 ,  A61P35/00 ,  C07D519/00

CPC classification number: A61K31/553 ,  A61K31/519 ,  A61P35/00 ,  C07D519/00

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of certain oncogenic proteins.

公开(公告)号：US20240226113A1

公开(公告)日：2024-07-11

申请号：US18439666

申请日：2024-02-12

Applicant: Kumquat Biosciences Inc.

Inventor： Baogen Wu ,  Liansheng Li ,  Pingda Ren ,  Yi Liu ,  Siling Zhao ,  Xiaoming Li ,  Zhiyong Chen ,  Zhimin Zhu

IPC: A61K31/553 ,  A61K31/519 ,  A61P35/00 ,  C07D519/00

CPC classification number: A61K31/553 ,  A61K31/519 ,  A61P35/00 ,  C07D519/00

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of certain oncogenic proteins.