公开(公告)号：US20140275198A1

公开(公告)日：2014-09-18

申请号：US14178090

申请日：2014-02-11

Applicant: Korea Basic Science Institute

Inventor： Gun-Hwa Kim ,  Soohyun Kim ,  Jong-Soon Choi ,  Seung II Kim ,  Edmond Changkyun Park

IPC: A61K31/4192 ,  A61K31/4174 ,  A61K31/201 ,  A61K31/15 ,  A61K31/18

CPC classification number: A61K31/4192 ,  A61K31/15 ,  A61K31/155 ,  A61K31/18 ,  A61K31/201 ,  A61K31/4174

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating diabetes or fatty liver, and more specifically relates to a pharmaceutical composition for preventing or treating diabetes or fatty liver containing a CYP4A (cytochrome P450A) inhibitor as an active ingredient. According to the present invention, the CYP4A inhibitor suppresses endoplasmic reticulum stress, reduces the blood insulin concentration and suppresses apoptosis of liver cells, and hence exhibits effects in preventing or treating diabetes or fatty liver.

Abstract translation: 本发明涉及用于预防或治疗糖尿病或脂肪肝的药物组合物，更具体地涉及含有CYP4A（细胞色素P450A）抑制剂作为活性成分的糖尿病或脂肪肝的预防或治疗药物组合物。 根据本发明，CYP4A抑制剂抑制内质网应激，降低血胰岛素浓度，抑制肝细胞凋亡，因此具有预防或治疗糖尿病或脂肪肝的作用。

公开(公告)号：US20160090640A1

公开(公告)日：2016-03-31

申请号：US14499801

申请日：2014-09-29

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY

Inventor： Joseph Kwon ,  Jong-Soon Choi ,  Duwoon Kim ,  Hee-Min Lee

IPC: C12Q1/70 ,  C12N7/00

CPC classification number: C12Q1/701 ,  C12N7/02 ,  C12N2770/16011 ,  C12N2770/32411 ,  C12Q1/706 ,  Y02A50/54

Abstract: Disclosed is an economic method for concentrating virus and detecting virus, such that virus in a sample solution having low virus concentration can be concentrated with high efficiency within a short time. Particularly, the method comprising the steps of: (A) adding Concanavalin A (Con A) to a sample solution containing a virus, and reacting the added Concanavalin A with the virus in the sample solution to form a virus-Concanavalin A conjugate; and (B) separating the virus-Concanavalin A conjugate from the sample solution.

Abstract translation: 公开了一种用于浓缩病毒和检测病毒的经济方法，使得可以在短时间内以高效率浓缩具有低病毒浓度的样品溶液中的病毒。 特别地，该方法包括以下步骤：（A）将伴刀豆球蛋白A（Con A）加入到含有病毒的样品溶液中，并将加入的伴刀豆球蛋白A与病毒在样品溶液中反应，形成病毒 - 伴刀豆球蛋白A缀合物; 和（B）从样品溶液中分离病毒 - 伴刀豆球蛋白A缀合物。

公开(公告)号：US09295667B2

公开(公告)日：2016-03-29

申请号：US14178090

申请日：2014-02-11

Applicant: Korea Basic Science Institute

Inventor： Gun-Hwa Kim ,  Soohyun Kim ,  Jong-Soon Choi ,  Seung Il Kim ,  Edmond Changkyun Park

IPC: A61K31/41 ,  A61K31/415 ,  A61K31/20 ,  A61K31/18 ,  A61K31/15 ,  A61K31/4192 ,  A61K31/155 ,  A61K31/201 ,  A61K31/4174

CPC classification number: A61K31/4192 ,  A61K31/15 ,  A61K31/155 ,  A61K31/18 ,  A61K31/201 ,  A61K31/4174

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating diabetes or fatty liver, and more specifically relates to a pharmaceutical composition for preventing or treating diabetes or fatty liver containing a CYP4A (cytochrome P450A) inhibitor as an active ingredient. According to the present invention, the CYP4A inhibitor suppresses endoplasmic reticulum stress, reduces the blood insulin concentration and suppresses apoptosis of liver cells, and hence exhibits effects in preventing or treating diabetes or fatty liver.

Abstract translation: 本发明涉及用于预防或治疗糖尿病或脂肪肝的药物组合物，更具体地涉及含有CYP4A（细胞色素P450A）抑制剂作为活性成分的糖尿病或脂肪肝的预防或治疗药物组合物。 根据本发明，CYP4A抑制剂抑制内质网应激，降低血胰岛素浓度，抑制肝细胞凋亡，因此具有预防或治疗糖尿病或脂肪肝的作用。

公开(公告)号：US10094831B2

公开(公告)日：2018-10-09

申请号：US14584394

申请日：2014-12-29

Applicant: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KOREA BASIC SCIENCE INSTITUTE ,  INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY

Inventor： Sung Yang ,  Du-Woon Kim ,  Joseph Kwon ,  Sung-A Hong ,  Jong-Soon Choi ,  Heemin Lee

IPC: G01N33/569 ,  G01N27/327 ,  G01N33/543

Abstract: Disclosed herein are a norovirus detection sensor and an electrochemical sensing method using the sensor. Specifically, in the norovirus detection sensor including a bioreceptor and a signal detector, a three-dimensional gold nanosurface electrode is used as a substrate, and the bioreceptor employs concanavalin A as a sample capture agent immobilized to the substrate and capable of binding to norovirus. Therefore, the norovirus detection sensor has improved sensitivity by employing the three-dimensional gold nanosurface electrode having a wide surface area. In addition, the norovirus detection sensor has effects of reducing manufacturing costs using a non-antibody material, i.e., concanavalin A which is inexpensive and readily available.

公开(公告)号：US09322071B2

公开(公告)日：2016-04-26

申请号：US14499801

申请日：2014-09-29

Applicant: Korea Basic Science Institute ,  Industry Foundation of Chonnam National University

Inventor： Joseph Kwon ,  Jong-Soon Choi ,  Duwoon Kim ,  Hee-Min Lee

IPC: C12Q1/70 ,  C12N7/00

CPC classification number: C12Q1/701 ,  C12N7/02 ,  C12N2770/16011 ,  C12N2770/32411 ,  C12Q1/706 ,  Y02A50/54

Abstract: Disclosed is an economic method for concentrating virus and detecting virus, such that virus in a sample solution having low virus concentration can be concentrated with high efficiency within a short time. Particularly, the method comprising the steps of: (A) adding Concanavalin A (Con A) to a sample solution containing a virus, and reacting the added Concanavalin A with the virus in the sample solution to form a virus-Concanavalin A conjugate; and (B) separating the virus-Concanavalin A conjugate from the sample solution.

Abstract translation: 公开了一种用于浓缩病毒和检测病毒的经济方法，使得可以在短时间内以高效率浓缩具有低病毒浓度的样品溶液中的病毒。 特别地，该方法包括以下步骤：（A）将伴刀豆球蛋白A（Con A）加入到含有病毒的样品溶液中，并将加入的伴刀豆球蛋白A与病毒在样品溶液中反应，形成病毒 - 伴刀豆球蛋白A缀合物; 和（B）从样品溶液中分离病毒 - 伴刀豆球蛋白A缀合物。