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公开(公告)号：US08675807B2
公开(公告)日：2014-03-18
申请号：US12867976
申请日：2009-04-08
申请人： Koichi Tanimoto , Masaharu Watabe , Jiro Kasahara
发明人： Koichi Tanimoto , Masaharu Watabe , Jiro Kasahara
IPC分类号： G21C1/01
CPC分类号： C02F1/66 , C02F1/688 , C02F2103/023 , G21C9/00 , G21C15/18 , G21C17/0225 , Y02E30/40
摘要： Disclosed is a basket 50 that is located within a basket containment vessel, into which a boric acid solution capable of dissolving a pH adjuster flows, and can allow a pH adjuster solution to flow out by the inflowing boric acid solution. The basket 50 includes a plurality of containment units 71 stacked in a vertical direction with a predetermined first space L1 therebetween. The pH adjuster can be stored in each of the containment units 71. Also disclosed is a pH adjusting device including the basket 50, the basket containment vessel in which the basket 50 can be contained and in which cooling water can be stored, and an overflow pipe that, within the basket containment vessel, allows the pH adjuster solution that is obtained from the pH adjuster dissolved in the cooling water to flow out.
摘要翻译： 公开了一种篮子50，其位于篮筐容纳容器内，能够溶解pH调节剂的硼酸溶液流入其中，并且可以通过流入的硼酸溶液使pH调节剂溶液流出。 篮子50包括沿垂直方向堆叠的多个容纳单元71，其间具有预定的第一空间L1。 pH调节器可以存储在每个容纳单元71中。还公开了一种pH调节装置，其包括筐50，可容纳筐50并且可以储存冷却水的筐容纳容器，并且溢流 在篮筐容纳容器内，允许从溶解在冷却水中的pH调节剂获得的pH调节剂溶液流出。
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公开(公告)号：US20100329410A1
公开(公告)日：2010-12-30
申请号：US12867976
申请日：2009-04-08
申请人： Koichi Tanimoto , Masaharu Watabe , Jiro Kasahara
发明人： Koichi Tanimoto , Masaharu Watabe , Jiro Kasahara
CPC分类号： C02F1/66 , C02F1/688 , C02F2103/023 , G21C9/00 , G21C15/18 , G21C17/0225 , Y02E30/40
摘要： Disclosed is a basket 50 that is located within a basket containment vessel, into which a boric acid solution capable of dissolving a pH adjuster flows, and can allow a pH adjuster solution to flow out by the inflowing boric acid solution. The basket 50 includes a plurality of containment units 71 stacked in a vertical direction with a predetermined first space L1 therebetween. The pH adjuster can be stored in each of the containment units 71. Also disclosed is a pH adjusting device including the basket 50, the basket containment vessel in which the basket 50 can be contained and in which cooling water can be stored, and an overflow pipe that, within the basket containment vessel, allows the pH adjuster solution that is obtained from the pH adjuster dissolved in the cooling water to flow out.
摘要翻译： 公开了一种篮子50，其位于篮筐容纳容器内，能够溶解pH调节剂的硼酸溶液流入其中，并且可以通过流入的硼酸溶液使pH调节剂溶液流出。 篮子50包括沿垂直方向堆叠的多个容纳单元71，其间具有预定的第一空间L1。 pH调节器可以存储在每个容纳单元71中。还公开了一种pH调节装置，其包括筐50，可容纳筐50并且可以储存冷却水的筐容纳容器，并且溢流 在篮筐容纳容器内，允许从溶解在冷却水中的pH调节剂获得的pH调节剂溶液流出。
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3.发明授权公开(公告)号：US09188393B2
公开(公告)日：2015-11-17
申请号：US13239621
申请日：2011-09-22
申请人： Issaku Fujita , Satoshi Hiraoka , Jiro Kasahara , Seiho Utsumi , Koichi Tanimoto
发明人： Issaku Fujita , Satoshi Hiraoka , Jiro Kasahara , Seiho Utsumi , Koichi Tanimoto
摘要： A pressure bulkhead has a plurality of holes and divides a low-pressure chamber at low pressure in the vertical direction. A cooling-tube bank is located in an upper section of the low-pressure chamber and performs heat exchange with low-pressure steam guided to the low-pressure chamber by introducing coolant therein to condense the low-pressure steam to low-pressure steam condensate. A reheat chamber serves as a lower section of the low-pressure chamber and stores the low-pressure steam condensate falling from the holes in the pressure bulkhead. A high-pressure-steam introducing unit introduces high-pressure steam within a high-pressure chamber at high pressure to the reheat chamber. A plurality of plate members are parallel to each other below the pressure bulkhead and extend in a falling direction of the condensate falling from the holes in the pressure bulkhead.
摘要翻译： 压力隔板具有多个孔，并且在垂直方向上以低压分压低压室。 冷却管组位于低压室的上部，通过在其中引入冷却剂而将低压蒸汽引导到低压室的低压蒸汽进行热交换，将低压蒸汽冷凝成低压蒸汽冷凝物 。 再加热室用作低压室的下部，并存储从压力舱壁上的孔落下的低压蒸汽冷凝物。 高压蒸汽引入单元将高压蒸汽在高压室内以高压引入再热室。 多个板构件在压力隔板下方彼此平行并且沿着从压力隔板中的孔落下的冷凝器的下降方向延伸。
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4.发明申请公开(公告)号：US20120216541A1
公开(公告)日：2012-08-30
申请号：US13239621
申请日：2011-09-22
申请人： Issaku Fujita , Satoshi Hiraoka , Jiro Kasahara , Seiho Utsumi , Koichi Tanimoto
发明人： Issaku Fujita , Satoshi Hiraoka , Jiro Kasahara , Seiho Utsumi , Koichi Tanimoto
IPC分类号： F01K23/06
摘要： A pressure bulkhead has a plurality of holes and divides a low-pressure chamber at low pressure in the vertical direction. A cooling-tube bank is located in an upper section of the low-pressure chamber and performs heat exchange with low-pressure steam guided to the low-pressure chamber by introducing coolant therein to condense the low-pressure steam to low-pressure steam condensate. A reheat chamber serves as a lower section of the low-pressure chamber and stores the low-pressure steam condensate falling from the holes in the pressure bulkhead. A high-pressure-steam introducing unit introduces high-pressure steam within a high-pressure chamber at high pressure to the reheat chamber. A plurality of plate members are parallel to each other below the pressure bulkhead and extend in a falling direction of the condensate falling from the holes in the pressure bulkhead.
摘要翻译： 压力隔板具有多个孔，并且在垂直方向上以低压分压低压室。 冷却管组位于低压室的上部，通过在其中引入冷却剂而将低压蒸汽引导到低压室的低压蒸汽进行热交换，将低压蒸汽冷凝成低压蒸汽冷凝物 。 再加热室用作低压室的下部，并存储从压力舱壁上的孔落下的低压蒸汽冷凝物。 高压蒸汽引入单元将高压蒸汽在高压室内以高压引入再热室。 多个板构件在压力隔板下方彼此平行并且沿着从压力隔板中的孔落下的冷凝器的下降方向延伸。
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公开(公告)号：US20090217991A1
公开(公告)日：2009-09-03
申请号：US11990144
申请日：2006-11-22
IPC分类号： F16L41/00
CPC分类号： F16L9/19 , F16L41/021 , F22B37/10 , F22B37/106 , F22B37/125 , Y10T137/85938
摘要： A pipe capable of eliminating the adverse influence of a cavity flow on a branch pipe is provided. In a pipe 1 which is branched from a main pipe 3 through which a high-temperature fluid flows and which is configured to be closable, dividing part 5, 7, and 9 are provided in the pipe 1 for dividing a channel in the pipe 1 into a plurality of small channels.
摘要翻译： 提供了能够消除空腔流对分支管的不利影响的管道。 在从主管3分支出的高温流体流通并配置为可关闭的管道1中，分配部件5,7和9设置在用于分配管道1中的通道的管道1中 成多个小通道。
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公开(公告)号：US09181217B2
公开(公告)日：2015-11-10
申请号：US14240466
申请日：2012-08-24
IPC分类号： C07B53/00 , C07C25/06 , C07C255/03 , C07D401/04
CPC分类号： C07D401/04 , C07B53/00 , C07C25/06 , C07C255/03
摘要： The present invention provides an industrially advantageous method for producing an optically active naphthalene compound useful as a therapeutic agent for dermatitis or the like. Specifically, the present invention provides a method for producing an optically active naphthalene compound [I], which comprises: a step of reacting a compound [a-1] and a compound [b-1] with each other in the presence of a base and a catalyst that is composed of a Pd compound and a tertiary phosphine ligand (step a); a step of asymmetrically hydrogenating a compound [c-1] in the presence of a hydrogen donor and a complex that is prepared from a ruthenium compound and a chiral ligand, or alternatively in the presence of an optically active oxazaborolidine compound (a CBS catalyst) and a boron hydride compound (step b); and a step of treating a compound [d-1] with a reducing agent (step c). (In the above formulae, Ra and Rb represent the same or different lower alkyl groups; and X1 represents a halogen atom.).
摘要翻译： 本发明提供了用于制造用作皮炎等的治疗剂的光学活性萘化合物的工业上有利的方法。 具体而言，本发明提供了一种光学活性萘化合物[I]的制造方法，其特征在于，在碱的存在下，使化合物[a-1]和化合物[b-1] 和由Pd化合物和叔膦配体组成的催化剂（步骤a）; 在氢供体和由钌化合物和手性配体制备的络合物的存在下，或者在光学活性的恶唑硼烷化合物（CBS催化剂）存在下，不对称地氢化化合物[c-1] 和硼氢化合物（步骤b）; 和用还原剂处理化合物[d-1]（步骤c）的步骤。 （上述式中，Ra和Rb表示相同或不同的低级烷基，X1表示卤素原子。
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![Pyrazolo[1,5-a] pyrimidine compounds as CB1 receptor antagonist](/abs-image/US/2014/12/30/US08921380B2/abs.jpg.150x150.jpg)
7.发明授权公开(公告)号：US08921380B2
公开(公告)日：2014-12-30
申请号：US13418811
申请日：2012-03-13
申请人： Koichi Tanimoto , Mariko Oi , Yasunori Tsuboi , Yasunori Moritani
发明人： Koichi Tanimoto , Mariko Oi , Yasunori Tsuboi , Yasunori Moritani
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00 , C07D487/04
CPC分类号： C07D487/04
摘要： Pyrazolo[1,5-a]pyrimidine compound, having CB1 receptor-antagonizing activity, of formula [I]: wherein R1 and R2 are the same or different and each is an optionally substituted aryl group, etc., R0 is hydrogen, an alkyl group, etc., E is —C(═O)— or —SO2—, R is a group of formula [i], [ii] or [iii], etc: Ring A is a C3-8 cycloalkyl group optionally fused to a benzene ring or a benzene ring, Q is a single bond or a methylene group, Ring B is a 4- to 7-membered aliphatic heterocyclic group, said cyclic group binding via its ring-carbon atom to the adjacent nitrogen atom, X is sulfur atom, etc., R3 is an alkyl group optionally substituted by an alkylthio group, R4 is hydrogen atom, an alkyl group, etc., one of RA and RB is an alkyl group, etc., and the other is hydrogen, an alkyl group, etc., or a pharmaceutically acceptable salt thereof.
摘要翻译： 具有式[I]的CB 1受体拮抗活性的吡唑并[1,5-a]嘧啶化合物：其中R1和R2相同或不同，并且各自为任选取代的芳基等，R 0是氢， 烷基等，E是-C（= O） - 或-SO 2 - ，R是式[ⅰ]，[ⅱ]或[ⅲ]等基团：环A是任选的C 3-8环烷基 稠合到苯环或苯环，Q是单键或亚甲基，环B是4-至7-元脂族杂环基，所述环状基团通过其环碳原子与相邻氮原子结合， X是硫原子等，R 3是任选被烷硫基取代的烷基，R 4是氢原子，烷基等，RA和RB之一是烷基等，另一个是氢 ，烷基等，或其药学上可接受的盐。
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公开(公告)号：US20080152067A1
公开(公告)日：2008-06-26
申请号：US11806321
申请日：2007-05-31
IPC分类号： G21C9/016
摘要： A nuclear reactor housing includes a vertically held pressurized water reactor and a cavity formed below the pressurized water reactor. A granulating member is positioned between the pressurized water reactor and the cavity and that accelerates granulation of debris falling from the pressurized water reactor into the cavity.
摘要翻译： 核反应堆壳体包括垂直保持的加压水反应器和形成在加压水反应器下方的空腔。 造粒构件位于加压水反应器和空腔之间，并且加速从压水反应堆落入空腔中的碎屑的造粒。
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公开(公告)号：US20100212605A1
公开(公告)日：2010-08-26
申请号：US12666658
申请日：2009-02-20
IPC分类号： F22B21/04
摘要： A steam generator is provided in which the total heat transfer efficiency can be improved by suppressing a reduction in the amount of heat exchange at an inlet side of heat transfer tubes while maintaining the effect of increasing the amount of heat exchange at an outlet side thereof. A steam generator includes a heat transfer tube group formed of a plurality of heat transfer tubes secured to a tube plate; an annular channel that is formed so as to cover the circumference of the heat transfer tube group and that has an opening for communicating with the heat transfer tube group at a lower portion thereof; a water supply box that is disposed at an upper portion of the annular channel and that supplies water to a cold-side portion of the heat transfer tubes; and a steam/water separator that is disposed above the heat transfer tube group and that separates water heated while passing from the annular passage along the circumference of the heat transfer tubes into steam and hot water, in which a porous plate for removing air bubbles is provided at an upper portion of the annular channel in the hot-side portion of the heat transfer tubes.
摘要翻译： 提供一种蒸汽发生器，其中通过抑制换热管入口侧的热交换量的减少，同时保持增加其出口侧的热交换量的效果，可以提高总传热效率。 蒸汽发生器包括由固定在管板上的多个传热管形成的传热管组; 形成为覆盖传热管组的圆周并且在其下部具有用于与传热管组连通的开口的环形通道; 供水箱，其设置在所述环形通道的上部，并且向所述传热管的冷侧部分供水; 以及蒸汽/水分离器，其设置在传热管组上方，并且将沿着传热管的圆周从环形通道流过的水分离成蒸汽和热水，其中用于除去气泡的多孔板是 设置在传热管的热侧部分中的环形通道的上部。
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公开(公告)号：US20090090424A1
公开(公告)日：2009-04-09
申请号：US11989526
申请日：2006-09-28
CPC分类号： B01F5/045 , B01F2005/0017
摘要： An object is to prevent thermal fatigue, resulting from variations in temperature interfaces, of piping having a fluid-mixing region where fluids of different temperatures are mixed. Piping 1 having a fluid-mixing region M includes a reducer 5 including an end portion 5e disposed substantially on a central axis of a main pipe 2. Low-temperature water flows through the reducer 5 at a lower velocity than high-temperature water flowing outside the end portion 5e. The low-temperature water and the high-temperature water have different temperatures. The low-temperature water and the high-temperature water are mixed in the fluid-mixing region M downstream of the reducer 5. The reducer 5 has a weld line 5f formed to connect the end portion 5e and an elbow portion 5d together. The distance between the weld line 5f and a downstream end 5a is equal to or larger than the inner diameter D of the main pipe 2.
摘要翻译： 目的在于防止混合具有不同温度的流体的流体混合区域的管道的温度界面变化引起的热疲劳。 具有流体混合区域M的管道1包括具有基本上设置在主管2的中心轴线上的端部5e的减速器5.低温水以比流过外部的高温水低的速度流过减速器5 端部5e。 低温水和高温水有不同的温度。 低温水和高温水在还原剂5下游的流体混合区域M中混合。还原剂5具有形成为将端部5e和肘部5d连接在一起的熔接线5f。 焊接线5f和下游端部5a之间的距离等于或大于主管2的内径D.
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