摘要:
An improved apparatus for producing welded metallic can bodies is provided. The apparatus has two roll-like revolving electrodes and an elongate electrode, and the lap portions of two can bodies are disposed respectively between the two revolving electrodes and the elongate electrode. An alternating current flowing through these lap portions is supplied by coupling the two revolving electrodes to an ac power supply, or by dividing the elongate electrode into two electrically insulated portions and coupling these portions to the power supply.
摘要:
A can body of surface treated steel plate, such as TFS, having adjacent longitudinally extending edges of tubular shaped member welded by irradiation of laser beam and provided with inside surface of welded seam having reliable paint retaining characteristic and free from projections, such as upset. For the purpose, welding is carried out such that inside and outside width of molten-solidified zone and structure changed zone will be maintained within a predetermined range and that metallic wire or elongated backing strip is located oppositely to lower surface of both edges being butt-welded.
摘要:
A device for feeding electric power to a roll-like revolving electrode in an electrical resistance welding machine includes a feeder rotor provided in a shaft formed integrally with a revolving electrode and a feeder plate extending in the moving direction of the revolving electrode and disposed in contact with the periphery of the feeder rotor. The periphery of the feeder rotor is electrically coupled to the electrode surface of the revolving electrode, and the feeder plate is connected to a power supply. Consequently, the electrode surface of the revolving electrode is electrically coupled to the power supply.
摘要:
The present invention provides a STATS inhibitor containing as an active ingredient, a quinolinecarboxamide derivative represented by the formula (I) (in the formula, W represents a bond or an alkylene chain; X represents O, S, or NR34; and R1 to R8 and R34 each represent H, halogen, alkyl, phenyl, furyl, thienyl, or the like.), or a pharmacologically acceptable salt thereof.
摘要:
A method and apparatus for guiding the opposed edges of sheet material into substantially abutting edge-to-edge relationship with one another and thereafter welding said edges by a high energy welding source to form a seam. The invention enables the continuous high speed butt welding of the sheet material to form cylindrical bodies. The apparatus includes three elements, a mandrel, a mandrel holder and tube holders. Sheet material is fed to around said mandrel and advanced by a tube holder with an edge of two opposite edges of said sheet material being in intimate contact with a basis plane of said mandrel holder. Another edges is slided into contact with above mentioned edge of sheet material making abutting relationship after passing through the basis plane of said mandrel holder. These abutting edges pass a high energy zone of a welder and butt welded to make a tube.
摘要:
Disclosed are a method of and apparatus for making a welded metallic can body by effecting a mash resistance welding on a lapped side portion of a can body preform by means of a combination of a cooled elongated electrode and a cooled rotary electrode and, as required, with wire electrodes interposed between the lapped side portion and these electrodes. Also, disclosed are a tinfree steel welded can body and its making method wherein it is formed by a mash resistance welding on a lapped side portion of a can body preform made from tinfree steel, without requiring the removal of surface chromium film from the welded portion and its vicinity.
摘要:
The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要:
The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomeruloscierosis.
摘要:
The present invention is directed to methods for the expansion of non-terminally differentiated cells (“precursor cells”) using agonists of Notch function, by inhibiting the differentiation of the cells without inhibiting proliferation (mitotic activity) such that an expanded population of non-terminally differentiated cells is obtained. The cells are preferably stem or progenitor cells. These expanded cells can be used in cell replacement therapy to provide desired cell populations and help in the regeneration of diseased and/or injured tissues. The expanded cell populations can also be made recombinant and used for gene therapy, or can be used to supply functions associated with a particular precursor cell or its progeny cell.
摘要:
The present invention relates to amino acid sequences of the encoded deltex protein. The invention further relates to fragments and other derivatives, and analogs, of deltex proteins. In specific embodiments, the invention relates to deltex protein derivatives and analogs of the invention which are functionally active, or which comprise one or more domains of a deltex protein, including but not limited to the Gln-rich clusters, SH3 binding domains, domains which mediate binding to Notch or to a Notch derivative containing Notch cdc10/SW16/ankyrin ("ANK") repeats, domains which mediate binding to a second deltex protein, or any combination of the foregoing. The present invention also relates to compositions based on deltex proteins.