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    Compounds, compositions and methods of modulating the mitochondrial apoptosis-induced channel (MAC)
    1.
    发明申请
    Compounds, compositions and methods of modulating the mitochondrial apoptosis-induced channel (MAC) 审中-公开
    调节线粒体凋亡诱导通道（MAC）的化合物，组合物和方法

    公开(公告)号：US20050267128A1

    公开(公告)日：2005-12-01

    申请号：US11137119

    申请日：2005-05-25

    申请人： Kathleen Kinnally ,  Evgeny Pavlov

    发明人： Kathleen Kinnally ,  Evgeny Pavlov

    IPC分类号： A61K31/138 ,  A61K31/24 ,  A61K31/495

    CPC分类号： A61K31/138 ,  A61K31/24 ,  A61K31/495

    摘要： The present invention relates to methods of treating conditions or diseases in which apoptosis is either desirable or undesirable. In particular, in conditions whereby it is desirable to inhibit unwanted cellular proliferation such as in cancers or in hyperproliferative disorders, treatment with an agent that promotes opening of the mitochondrial apoptosis induced channel (MAC) is beneficial. In conditions whereby there is unwanted apoptosis, such as in certain conditions exemplified by cell death at the site of injury, such as stroke, Alzheimer's disease, myocardial infarct, traumatic brain injury and in spinal cord injury, it is desirable to treat with an agent that prevents opening of the MAC, or promotes closure of the MAC. The present invention also relates to pharmaceutical compositions comprising such agents. Methods of screening for novel agents are also disclosed.

    摘要翻译： 本发明涉及治疗其中凋亡是期望的或不期望的疾病的方法。 特别地，在期望抑制诸如癌症或过度增殖性疾病的不想要的细胞增殖的条件下，用促进线粒体凋亡诱导通道（MAC）开放的药物的治疗是有益的。 在有不想要的细胞凋亡的条件下，例如在损伤部位例如中风，阿尔茨海默氏病，心肌梗塞，创伤性脑损伤和脊髓损伤的细胞死亡的某些情况下，需要用药剂 这阻止MAC的打开，或者促进关闭MAC。 本发明还涉及包含这些试剂的药物组合物。 还公开了筛选新型试剂的方法。

    METHOD AND APPARATUS FOR MOVING MOLTEN METAL
    2.
    发明申请
    METHOD AND APPARATUS FOR MOVING MOLTEN METAL 有权
    用于移动金属的方法和装置

    公开(公告)号：US20160052050A1

    公开(公告)日：2016-02-25

    申请号：US14780796

    申请日：2014-03-28

    申请人： Evgeny PAVLOV

    发明人： Evgeny Pavlov ,  Dmitry Nikolaevich Ivanov ,  Pavel Olegovich Gasanov ,  Andrew Ivanovich Gulayev

    IPC分类号： B22D11/115 ,  H02K44/06 ,  F27D27/00 ,  B22D11/12 ,  B22D27/02

    CPC分类号： B22D11/115 ,  B22D11/122 ,  B22D27/02 ,  F27D3/14 ,  F27D27/00 ,  F27D2003/0039 ,  F27D2003/0054 ,  H01F7/206 ,  H02K44/06 ,  H05B6/34 ,  H05B6/367

    摘要： Methods and apparatus for moving a molten metal are provided in which the electromagnetic inductor includes at least two pairs of electromagnetic pole pairs and in which a first magnetic field component is generated between one pole in a first electromagnetic pole pair and a second pole in a different electromagnetic pole pair, and in which a second magnetic field component is generated between the two poles in one or more electromagnetic pole pairs, the second magnetic field component thereby generating one or more eddy currents in the molten metal. Those eddy currents are generally parallel to the surface of the molten metal and so have greater magnitude and extent that eddy currents perpendicular to the surface. Such eddy currents provide useful additional movement to the molten metal, for instance for stirring purposes, particularly when the depth of molten metal is small.

    摘要翻译： 提供了用于移动熔融金属的方法和装置，其中电磁感应器包括至少两对电磁极对，并且其中在第一电磁极对中的一个极和不同的第二极之间产生第一磁场分量 电磁极对，并且其中在一个或多个电磁极对中的两个极之间产生第二磁场分量，所述第二磁场分量由此在所述熔融金属中产生一个或多个涡流。 这些涡流通常平行于熔融金属的表面，因此具有垂直于表面的涡流的更大的幅度和程度。 这种涡流为熔融金属提供了有用的附加运动，例如用于搅拌目的，特别是当熔融金属的深度小时。