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1.发明申请公开(公告)号：US20180177963A1
公开(公告)日：2018-06-28
申请号：US15579228
申请日：2016-06-01
CPC分类号： A61M16/026 , A61B5/085 , A61B5/087 , A61B5/7203 , A61B5/7225 , A61B5/725 , A61B5/742 , A61M16/0677 , A61M2016/0027 , A61M2016/0036 , A61M2202/0208 , A61M2205/3303 , A61M2205/502 , A61M2205/505 , A61M2230/06 , A61M2230/205 , A61M2230/42 , A61M2230/432 , A61M2230/435 , A61M2230/46 , A61M2202/0007 , A61M2230/005
摘要： A Moving Window Least Squares (MWLS) approach is applied to estimate respiratory system parameters from measured air flow and pressure. In each window, elastance Ers (or resistance Rrs) is first estimated, and a Kalman filter may be applied to the estimate. This is input to a second estimator that estimates R (or E), to which a second Kalman filter may be applied. Finally, the estimated Ers and Rrs are used to calculate muscle pressure Pmus(t) in the time window. A system comprises a ventilator (100), an airway pressure sensor (112), and an air flow sensor (114), and a respiratory system analyzer (120) that performs the MWLS estimation. Estimated results may be displayed on a display (110) of the ventilator or of a patient monitor. The estimated Pmus(t) may be used to reduce patient-ventilator dyssynchrony, or integrated to generate a Work of Breathing (WOB) signal for controlling ventilation.
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公开(公告)号：US20210205558A1
公开(公告)日：2021-07-08
申请号：US15999588
申请日：2017-02-01
IPC分类号： A61M16/00
摘要： A respiratory monitoring apparatus (10) includes a central venous pressure sensor (24) configured to measure a central venous pressure (CVP) signal of a patient. At least one processor (32, 34, 36, 38, 40, 42, 44, 58) is programmed to process the CVP signal to generate respiratory information for the patient by operations including: segmenting the CVP signal based on detected breath intervals; calculating a surrogate muscle pressure signal from the segmented CVP signal; and filtering the surrogate muscle pressure signal to remove a cardiac activity component a cardiac activity component of the surrogate respiratory muscle pressure signal.
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公开(公告)号：US20210386948A1
公开(公告)日：2021-12-16
申请号：US17317031
申请日：2021-05-11
发明人： WILLIAM TRUSCHEL , PABLO ANDRES Ñañez Ojeda , FRANCESCO VICARIO , MICHAEL POLKEY , NIKOLAOS KARAMOLEGKOS
摘要： A method for controlling a ventilator to provide variable volume (VV) with average volume assured pressure support (AVAPS), including: producing a VV target volume using a VV distribution function; producing a volume error Verror that is the difference between the VV target volume and a measured volume of the previous breath; scaling the volume error Verror; producing a VV target difference as the difference between VV target volume and the VV target volume of the previous breath; producing a modified volume error by adding the VV target difference to the scaled volume error Verror; producing a delta pressure support ΔPS based upon the modified volume error and a dynamic compliance; and producing a current pressure support value based upon the delta pressure support ΔPS and the pressure support value of the previous breath.
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公开(公告)号：US20180001042A1
公开(公告)日：2018-01-04
申请号：US15538245
申请日：2015-12-21
CPC分类号： A61M16/026 , A61M16/0057 , A61M2016/0027 , A61M2016/003 , A61M2202/0208 , A61M2205/3303 , A61M2205/3344 , A61M2205/502 , A61M2230/04 , A61M2230/205 , G05B17/02 , G06F19/3481 , G16H40/63 , G16H50/50
摘要： A mechanical ventilator (10) is connected with a ventilated patient (12) to provide ventilation in accordance with ventilator settings of the mechanical ventilator. Physiological values (variables) are acquired for the ventilated patient using physiological sensors (32). A ventilated patient cardiopulmonary (CP) model (40) is fitted to the acquired physiological variables values to generate a fitted ventilated patient CP model by fine-tuning its parameters (50). Updated ventilator settings are determined by adjusting model ventilator settings of the fitted ventilated patient CP model to minimize a cost function (60). The updated ventilator settings may be displayed on a display component (22) as recommended ventilator settings for the ventilated patient, or the ventilator settings of the mechanical ventilator may be automatically changed to the updated ventilator settings so as to automatically control the mechanical ventilator.
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5.发明申请公开(公告)号：US20180317808A1
公开(公告)日：2018-11-08
申请号：US15772982
申请日：2016-10-25
发明人： DONG WANG , FRANCESCO VICARIO , ANTONIO ALBANESE , NIKOLAOS KARAMOLEGKOS , NICOLAS WADIH CHBAT , LIMEI CHENG
CPC分类号： A61B5/0816 , A61B5/085 , A61B5/4836 , A61B5/6867 , A61B5/7221 , A61B5/7242 , A61M16/0051 , A61M16/026 , A61M2016/0027 , A61M2016/0036 , A61M2230/40
摘要： In respiratory monitoring, a breathing cycle detector (44) detects a breath interval in airway pressure and/or flow data. A respiratory parameters estimator and validator (30) asynchronously fits the airway pressure and airway flow data to an equation of motion of the lungs relating airway pressure and airway flow to generate asynchronously estimated respiratory parameters for the breath interval, using a sliding time window that is not synchronized with the breath interval. The asynchronously estimated respiratory parameters for the breath interval are validated using at least one physiological plausibility criterion defined with respect to the breath interval. Responsive to failure of the validation, the airway pressure and airway flow data are synchronously fitted to the equation of motion of the lungs to generate synchronously estimated respiratory parameters for the breath interval. The synchronous fitting is performed in a time window aligned with the breath interval.
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6.发明申请公开(公告)号：US20180279963A1
公开(公告)日：2018-10-04
申请号：US15763876
申请日：2016-09-18
摘要： Respiratory variables are estimated on a per-breath basis from airway pressure and flow data acquired by airway pressure and flow sensors (20, 22). A breath detector (28) detects a breath interval. A per-breath respiratory variables estimator (30) fits the airway pressure and flow data over the detected breath interval to an equation of motion of the lungs relating airway pressure, airway flow, and a single-breath parameterized respiratory muscle pressure profile (40, 42) to generate optimized parameter values for the single-breath parameterized respiratory muscle pressure profile. Respiratory muscle pressure is estimated as a function of time over the detected breath interval as the single-breath parameterized respiratory muscle pressure profile with the optimized parameter values, and may for example be displayed as a trend line on a display device (26, 36) or integrated (32) to generate Work of Breathing (WoB) for use in adjusting settings of a ventilator (10).
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7.发明申请公开(公告)号：US20180001041A1
公开(公告)日：2018-01-04
申请号：US15546774
申请日：2016-01-12
摘要： A medical ventilator (10) performs a method including: receiving measurements of pressure of air inspired by or expired from a ventilated patient (12) operatively connected with the medical ventilator; receiving measurements of air flow into or out of the ventilated patient operatively connected with the medical ventilator; dividing a breath time interval into a plurality of fitting regions (60); and simultaneously estimating respiratory system's resistance and compliance or elastance, and respiratory muscle pressure in each fitting region by fitting to a time series of pressure and air flow samples in that fitting region. In one approach, the fitting includes parameterizing the respiratory muscle pressure by a continuous differentiable function, such as a polynomial function, over the fitting region. In another approach, the fitting is to an equation of motion of the lungs in each fitting region, while monotonicity constraints and inequalities bounding at least the respiratory muscle pressure Pmus(t) and respiratory system's resistence R and compliance C are applied to the respiratory muscle pressure in each region.
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