公开(公告)号：US09738641B2

公开(公告)日：2017-08-22

申请号：US14907095

申请日：2014-08-14

申请人： Kalvista Pharmaceuticals Limited

发明人： Hannah Joy Edwards ,  David Michael Evans ,  Rebecca Louise Davie ,  David Philip Rooker ,  Steven John Hewison

IPC分类号： A61K31/535 ,  A01N43/42 ,  A61K31/44 ,  C07D265/36 ,  C07D498/02 ,  C07D471/02 ,  C07D491/02 ,  C07D513/02 ,  C07D515/02 ,  C07D471/04 ,  A61K31/5365 ,  C07D401/04 ,  C07D413/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  A61K31/5365 ,  C07D401/04 ,  C07D413/04 ,  C07D519/00

摘要： The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein A, B, W, X and Y are as defined herein.

公开(公告)号：US09234000B2

公开(公告)日：2016-01-12

申请号：US14687127

申请日：2015-04-15

申请人： KalVista Pharmaceuticals Limited

发明人： David Michael Evans ,  Rebecca Louise Davie ,  Hannah Joy Edwards ,  David Philip Rooker

IPC分类号： C07D333/38 ,  C07D207/16 ,  C07D213/81 ,  C07D215/48 ,  C07D261/18 ,  C07C237/20 ,  C07C317/28 ,  C07K5/065 ,  C07C237/22 ,  C07K5/062 ,  C07K5/06 ,  C07D231/14 ,  C07D333/24 ,  C07D333/60 ,  C07D233/90 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D207/34 ,  C07D277/30 ,  C07D277/56 ,  C07D209/18 ,  C07D213/56 ,  C07D307/68 ,  A61K38/00

CPC分类号： C07K5/06078 ,  A61K38/00 ,  C07C237/20 ,  C07C237/22 ,  C07C317/28 ,  C07D207/16 ,  C07D207/34 ,  C07D209/18 ,  C07D213/56 ,  C07D213/81 ,  C07D215/48 ,  C07D231/14 ,  C07D233/90 ,  C07D261/18 ,  C07D277/30 ,  C07D277/56 ,  C07D307/68 ,  C07D333/24 ,  C07D333/38 ,  C07D333/60 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07K5/06 ,  C07K5/06026 ,  C07K5/06034 ,  C07K5/06191

摘要： The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R1 to R9 are as defined herein.

公开(公告)号：US20220002275A1

公开(公告)日：2022-01-06

申请号：US17480424

申请日：2021-09-21

申请人： KALVISTA PHARMACEUTICALS LIMITED

发明人： Rebecca Louise Davie ,  Hannah Joy Edwards ,  David Michael Evans ,  Simon Teanby Hodgson ,  Stephen John Pethen ,  David Philip Rooker

IPC分类号： C07D403/14 ,  C07D403/06 ,  C07D401/10 ,  C07D401/14 ,  A61P7/10 ,  C07D403/10

摘要： The present invention provides a selection of compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.

公开(公告)号：US11180484B2

公开(公告)日：2021-11-23

申请号：US16301192

申请日：2017-05-31

申请人： KALVISTA PHARMACEUTICALS LIMITED

发明人： Rebecca Louise Davie ,  Hanna Joy Edwards ,  David Michael Evans ,  Simon Teanby Hodgson ,  Stephen John Pethen ,  David Philip Rooker

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D403/06 ,  C07D401/10 ,  A61P7/10 ,  C07D403/10

摘要： The present invention provides a selection of compounds of formula (I): (I) compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.