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公开(公告)号：US11084809B2
公开(公告)日：2021-08-10
申请号：US16944658
申请日：2020-07-31
IPC分类号： A61K31/4439 , C07D413/14 , C07D401/14 , A61K31/445 , A61K31/496 , A61P9/00 , C07D401/10 , A61P43/00 , C07D231/14 , C07D401/06 , C07D403/10 , C07D409/14
摘要： The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.
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公开(公告)号：US09834513B2
公开(公告)日：2017-12-05
申请号：US15602688
申请日：2017-05-23
发明人： Christine Elizabeth Allan , Andrzej Roman Batt , Rebecca Louise Davie , Hannah Joy Edwards , David Michael Evans , Stephen John Pethen
IPC分类号： C07D207/34 , C07D231/14 , C07D417/14 , C07D417/06 , C07D413/06 , C07D409/14 , C07D409/06 , C07D403/10 , C07D401/14 , C07D401/10 , C07D401/06 , C07D249/10
CPC分类号： C07D207/34 , C07D231/14 , C07D249/10 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/10 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14
摘要： The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R1 to R3, R5 to R9, A, P, V, W, X, Y and Z are as defined herein.
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公开(公告)号：US09738641B2
公开(公告)日：2017-08-22
申请号：US14907095
申请日：2014-08-14
发明人： Hannah Joy Edwards , David Michael Evans , Rebecca Louise Davie , David Philip Rooker , Steven John Hewison
IPC分类号： A61K31/535 , A01N43/42 , A61K31/44 , C07D265/36 , C07D498/02 , C07D471/02 , C07D491/02 , C07D513/02 , C07D515/02 , C07D471/04 , A61K31/5365 , C07D401/04 , C07D413/04 , C07D519/00
CPC分类号： C07D471/04 , A61K31/5365 , C07D401/04 , C07D413/04 , C07D519/00
摘要： The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein A, B, W, X and Y are as defined herein.
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公开(公告)号：US20220153724A1
公开(公告)日：2022-05-19
申请号：US17666213
申请日：2022-02-07
IPC分类号： C07D401/14 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present invention provides compounds of formula (I), compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, R12, R13, A, L, B, n, W, X, Y and Z are as defined herein.
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公开(公告)号：US10221161B2
公开(公告)日：2019-03-05
申请号：US14907842
申请日：2014-08-14
IPC分类号： C07D401/14 , C07D413/14 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/14 , C07D417/14 , C07D471/04
摘要： The present invention provides compounds of formula (I), compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, R12, R13, A, L, B, n, W, X, Y and Z are as defined herein.
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公开(公告)号：US09670157B2
公开(公告)日：2017-06-06
申请号：US14759542
申请日：2014-01-08
发明人： Christine Elizabeth Allan , Andrzej Roman Batt , Rebecca Louise Davie , Hannah Joy Edwards , David Michael Evans , Stephen John Pethen
IPC分类号： C07D207/34 , C07D401/14 , C07D231/14 , C07D401/06 , C07D401/10 , C07D403/10 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D249/10
CPC分类号： C07D207/34 , C07D231/14 , C07D249/10 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/10 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14
摘要： The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R1 to R3, R5 to R9, A, P, V, W, X, Y and Z are as defined herein.
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公开(公告)号：US20220002275A1
公开(公告)日：2022-01-06
申请号：US17480424
申请日：2021-09-21
发明人： Rebecca Louise Davie , Hannah Joy Edwards , David Michael Evans , Simon Teanby Hodgson , Stephen John Pethen , David Philip Rooker
IPC分类号： C07D403/14 , C07D403/06 , C07D401/10 , C07D401/14 , A61P7/10 , C07D403/10
摘要： The present invention provides a selection of compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.
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公开(公告)号：US11198691B2
公开(公告)日：2021-12-14
申请号：US16804872
申请日：2020-02-28
IPC分类号： A61K31/445 , A61K31/496 , C07D413/14 , A61K31/4439 , A61P9/00 , C07D409/14 , C07D231/14 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/10 , A61P43/00
摘要： The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.
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公开(公告)号：US11180484B2
公开(公告)日：2021-11-23
申请号：US16301192
申请日：2017-05-31
发明人： Rebecca Louise Davie , Hanna Joy Edwards , David Michael Evans , Simon Teanby Hodgson , Stephen John Pethen , David Philip Rooker
IPC分类号： C07D401/14 , C07D403/14 , C07D403/06 , C07D401/10 , A61P7/10 , C07D403/10
摘要： The present invention provides a selection of compounds of formula (I): (I) compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.
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公开(公告)号：US09533987B2
公开(公告)日：2017-01-03
申请号：US14892055
申请日：2014-05-23
发明人： Rebecca Louise Davie , Hannah Joy Edwards , David Michael Evans , Simon Teanby Hodgson , Iain Miller , Andrew Richard Novak , Alun John Smith , Michael John Stocks
IPC分类号： C07D401/14 , C07D403/14 , C07D417/14 , C07D471/14 , A61K31/4725 , C07D471/04 , C07D413/14 , C07D417/06
CPC分类号： C07D471/04 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/06 , C07D417/14
摘要： The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.
摘要翻译： 本发明提供式（I）化合物：包含这些化合物的组合物; 这种化合物在治疗中的用途（例如在治疗或预防涉及血浆激肽释放酶活性的疾病或病症中）; 以及用这些化合物治疗患者的方法; 其中R5，R6，R7，A，B，W，X，Y和Z如本文所定义。
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