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公开(公告)号：US09079832B2
公开(公告)日：2015-07-14
申请号：US14072352
申请日：2013-11-05
Applicant: Jonathan Timothy Reeves , Chris H. Senanayake
Inventor： Jonathan Timothy Reeves , Chris H. Senanayake
IPC: C07C313/06 , C07D319/18 , C07D295/185 , C07C327/46
CPC classification number: C07C313/06 , C07C327/46 , C07C2601/02 , C07C2601/04 , C07C2603/74 , C07C2603/94 , C07D295/185 , C07D319/18
Abstract: Disclosed is a process for making diastereomeric N-sulfinyl α-amino amides by reaction of chiral sulfinimines with formamides and lithium diisopropylamide. The process of the invention provides the N-sulfinyl α-amino amides in high yields and with high diastereoselectivity.
Abstract translation: 公开了通过手性亚磺酰亚胺与甲酰胺和二异丙基氨基锂的反应来制备非对映异构N-亚磺酰基α-氨基酰胺的方法。 本发明的方法以高产率和高非对映选择性提供了N-亚磺酰基α-氨基酰胺。
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2.发明授权Carbonate and carbamate modified forms of glucocorticoids in combination with B2 adrenergic agonists 有权碳酸酯和氨基甲酸酯修饰形式的糖皮质激素与B2肾上腺素能激动剂组合公开(公告)号：US08445470B2
公开(公告)日：2013-05-21
申请号：US12277004
申请日：2008-11-24
Applicant: Mark G. Currie , Steve Jones , Paul Grover , Chris H. Senanayake , Q. Kevin Fang
Inventor： Mark G. Currie , Steve Jones , Paul Grover , Chris H. Senanayake , Q. Kevin Fang
IPC: A61K31/58 , A61K31/573
CPC classification number: A61K45/06 , A61K31/137 , A61K31/56 , A61K31/573 , A61K31/58 , Y10S514/87 , A61K2300/00
Abstract: Compositions containing β2 adrenergic agonists in combination with carbonates and carbamates of the formula. and in combination with related steroid carbonates and carbamates are disclosed. The compositions are useful for treating bronchospasm, for inducing bronchodilation and for treating rhinitis, asthma, and chronic obstructive pulmonary disease (COPD) and inflammatory diseases, particularly by inhalation.
Abstract translation: 含有β2肾上腺素能激动剂与下式的碳酸酯和氨基甲酸酯组合的组合物。 并结合相关类固醇碳酸酯和氨基甲酸酯。 该组合物可用于治疗支气管痉挛，用于诱发支气管扩张和治疗鼻炎，哮喘和慢性阻塞性肺疾病（COPD）和炎性疾病，特别是通过吸入治疗。
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公开(公告)号：US08222369B2
公开(公告)日：2012-07-17
申请号：US12552569
申请日：2009-09-02
Applicant: Carl Alan Busacca , Fabrice Gallou , Nizar Haddad , Azad Hossain , Suresh R. Kapadia , Jianxiu Liu , Chris H. Senanayake , Xudong Wei , Nathan K. Yee
Inventor： Carl Alan Busacca , Fabrice Gallou , Nizar Haddad , Azad Hossain , Suresh R. Kapadia , Jianxiu Liu , Chris H. Senanayake , Xudong Wei , Nathan K. Yee
IPC: C07K1/00
CPC classification number: C07D401/04 , C07D417/04 , C07D487/04 , C07K5/0808 , C07K5/0812
Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I) wherein a hydroxyl-substituted macrocyclic compound of formula (3) is reacted with a sulfonyl-substituted compound of formula QUIN: The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
Abstract translation: 公开了制备式（I）的大环化合物的方法，其中式（3）的羟基取代的大环化合物与磺酰基取代的式QuIN化合物反应：式（I）化合物是有效的活性剂 用于治疗丙型肝炎病毒（HCV）感染。
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公开(公告)号：US07964753B2
公开(公告)日：2011-06-21
申请号：US12794991
申请日：2010-06-07
Applicant: Gerald J. Tanoury , Chris H. Senanayake , Donald W. Kessler
Inventor： Gerald J. Tanoury , Chris H. Senanayake , Donald W. Kessler
IPC: C07C231/20 , C07C233/03
CPC classification number: A61K31/205 , C07B2200/13 , C07C231/24 , C07C233/25 , C07C233/43
Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
Abstract translation: 公开了制备R，R-福莫特醇L-酒石酸盐的高纯度盐的方法。 该方法通过重结晶新型多晶型物提供最热力学稳定的多晶型物。
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公开(公告)号：US20100204336A1
公开(公告)日：2010-08-12
申请号：US12767043
申请日：2010-04-26
Applicant: Gerald J. Tanoury , Chris H. Senanayake , Donald W. Kessler
Inventor： Gerald J. Tanoury , Chris H. Senanayake , Donald W. Kessler
IPC: A61K31/167 , C07C233/24 , A61P11/08
CPC classification number: A61K31/205 , C07B2200/13 , C07C231/24 , C07C233/25 , C07C233/43
Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
Abstract translation: 公开了制备R，R-福莫特醇L-酒石酸盐的高纯度盐的方法。 该方法通过重结晶新型多晶型物提供最热力学稳定的多晶型物。
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Patent Agency Ranking
公开(公告)号：US06720453B2
公开(公告)日：2004-04-13
申请号：US10238204
申请日：2002-09-10
Applicant: Gerald J. Tanoury , Chris H. Senanayake , Donald W Kessler
Inventor： Gerald J. Tanoury , Chris H. Senanayake , Donald W Kessler
IPC: C07C23120
CPC classification number: A61K31/205 , C07B2200/13 , C07C231/24 , C07C233/25 , C07C233/43
Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
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公开(公告)号：US06472563B1
公开(公告)日：2002-10-29
申请号：US10037183
申请日：2001-11-09
Applicant: Gerald J. Tanoury , Chris H. Senanayake , Donald W Kessler
Inventor： Gerald J. Tanoury , Chris H. Senanayake , Donald W Kessler
IPC: C07C23120
CPC classification number: A61K31/205 , C07B2200/13 , C07C231/24 , C07C233/25 , C07C233/43
Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
Abstract translation: 公开了制备R，R-福莫特醇L-酒石酸盐的高纯度盐的方法。 该方法通过重结晶新型多晶型物提供最热力学稳定的多晶型物。
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公开(公告)号：US20120165534A1
公开(公告)日：2012-06-28
申请号：US13318706
申请日：2010-05-03
Applicant: Nitinchandra D. Patel , Chris H. Senanayake , Wenjun Tang , Xudong Wei , Nathan K. Yee
Inventor： Nitinchandra D. Patel , Chris H. Senanayake , Wenjun Tang , Xudong Wei , Nathan K. Yee
IPC: C07D215/20 , C07F5/02
CPC classification number: C07D215/20 , C07D215/36 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07F5/025
Abstract: Disclosed are methods for the preparation of bromo-substituted quinolines of the formula (I) where R is aryl, heteroaryl, alkyl, alkenyl or alkynyl, which are useful as intermediates in the preparation of agents for the treatment of hepatitis C viral (HCV) infections: Formula (I).
Abstract translation: 公开了制备式（I）的溴取代喹啉的方法，其中R是芳基，杂芳基，烷基，烯基或炔基，其可用作制备用于治疗丙型肝炎病毒（HCV）的药剂的中间体 感染：式（I）。
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公开(公告)号：US20100249459A1
公开(公告)日：2010-09-30
申请号：US12794991
申请日：2010-06-07
Applicant: Gerald J. Tanoury , Chris H. Senanayake , Donald W. Kessler
Inventor： Gerald J. Tanoury , Chris H. Senanayake , Donald W. Kessler
IPC: C07C233/43
CPC classification number: A61K31/205 , C07B2200/13 , C07C231/24 , C07C233/25 , C07C233/43
Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
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10.发明授权Carbonate and carbamate modified forms of glucocorticoids in combination with B2 adrenergic agonists 有权碳酸酯和氨基甲酸酯修饰形式的糖皮质激素与B2肾上腺素能激动剂组合公开(公告)号：US07253156B2
公开(公告)日：2007-08-07
申请号：US11364659
申请日：2006-02-28
Applicant: Mark G. Currie , Steve Jones , Paul Grover , Chris H. Senanayake , Q. Kevin Fang
Inventor： Mark G. Currie , Steve Jones , Paul Grover , Chris H. Senanayake , Q. Kevin Fang
IPC: A61K31/56
CPC classification number: A61K45/06 , A61K31/137 , A61K31/56 , A61K31/573 , A61K31/58 , Y10S514/87 , A61K2300/00
Abstract: Compositions containing β2 adrenergic agonists in combination with carbonates and carbamates of the formula and in combination with related steroid carbonates and carbamates are disclosed. The compositions are useful for treating bronchospasm, for inducing bronchodilation and for treating rhinitis, asthma, and chronic obstructive pulmonary disease (COPD) and inflammatory diseases, particularly by inhalation.
Abstract translation: 公开了含有β2肾上腺素能激动剂与下式的碳酸酯和氨基甲酸酯并与相关的类固醇碳酸酯和氨基甲酸酯组合的组合物。 该组合物可用于治疗支气管痉挛，用于诱发支气管扩张和治疗鼻炎，哮喘和慢性阻塞性肺疾病（COPD）和炎性疾病，特别是通过吸入治疗。
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