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    Microelectrode systems for neuro-stimulation and neuro-sensing and microchip packaging and related methods
    1.
    发明申请
    Microelectrode systems for neuro-stimulation and neuro-sensing and microchip packaging and related methods 失效
    用于神经刺激和神经感测和微芯片封装的微电极系统及相关方法

    公开(公告)号：US20070123766A1

    公开(公告)日：2007-05-31

    申请号：US11540087

    申请日：2006-09-29

    申请人： John Whalen ,  James Weiland ,  Mark Humayun

    发明人： John Whalen ,  James Weiland ,  Mark Humayun

    IPC分类号： A61B5/04

    CPC分类号： A61B5/04001 ,  A61B5/685 ,  A61B2562/0215 ,  A61B2562/0217 ,  A61B2562/125 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/0551 ,  A61N1/37205 ,  B82Y10/00 ,  B82Y15/00 ,  B82Y30/00

    摘要： Microelectrode assemblies and related methods are disclosed for bio-stimulating and/or bio-sensing a target tissue. The assemblies can include a two-side substrate, an array of microelectrodes, each of the microelectrodes including a nano-wire embedded within the substrate and extending from a proximal end to a distal end and through the substrate, each nano-wire having a diameter preferably less than 1 μm. The substrate can include portions made of nano-porous material(s) through which the microelectrodes pass. The substrate with the embedded nano-wires can effectively be fluid impermeable. The proximal ends of the nano-wires can be adapted to be connected to an electronic device and the distal ends are adapted to be disposed in a biological environment for bio-stimulating a target tissue and/or bio-sensing activities of the target tissue. Suitable alloys such as platinum, platinum-iridium, and/or other noble-metal-alloyed compositions can be used for the nano-wires.

    摘要翻译： 公开了用于生物刺激和/或生物感测靶组织的微电极组件和相关方法。 组件可以包括两侧基板，微电极阵列，每个微电极包括嵌入基板内的纳米线，并从近端延伸到远端并穿过基板，每个纳米线具有直径 优选小于1um。 基板可以包括由微电极通过的纳米多孔材料制成的部分。 具有嵌入式纳米线的基板可以有效地不透液体。 纳米线的近端可以适于连接到电子设备，并且远端适于设置在用于生物刺激靶组织和/或靶组织的生物感测活动的生物环境中。 合适的合金如铂，铂 - 铱和/或其它贵金属合金组合物可用于纳米线。

    Microelectrode system for neuro-stimulation and neuro-sensing and microchip packaging
    2.
    发明申请
    Microelectrode system for neuro-stimulation and neuro-sensing and microchip packaging 审中-公开
    用于神经刺激和神经感测和微芯片封装的微电极系统

    公开(公告)号：US20070187238A1

    公开(公告)日：2007-08-16

    申请号：US11540899

    申请日：2006-09-29

    申请人： John Whalen ,  James Weiland ,  Mark Humayun ,  Peter Searson

    发明人： John Whalen ,  James Weiland ,  Mark Humayun ,  Peter Searson

    IPC分类号： G01N27/26

    CPC分类号： B82Y10/00 ,  A61B5/04001 ,  A61B2562/125 ,  A61N1/05 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/0551 ,  A61N1/37205 ,  B82Y15/00

    摘要： A microelectrode assembly for bio-stimulating and/or bio-sensing a target tissue includes a substrate having a first side and a second side, an array of microelectrodes, each of the microelectrodes including a nano-wire embedded within the substrate and extending from a proximal end at the first side to a distal end at the second side, each nano-wire having a diameter less than 1 μm. The substrate with the embedded nano-wires is fluid impermeable. The proximal ends of the nano-wires are adapted to be connected to an electronic device and the distal ends are adapted to be disposed in a biological environment for bio-stimulating a target tissue and/or bio-sensing activities of the target tissue.

    摘要翻译： 用于生物刺激和/或生物感测靶组织的微电极组件包括具有第一侧和第二侧的衬底，微电极阵列，每个微电极包括嵌入衬底内的纳米线，并从 在第一侧的近端到第二侧的远端，每个纳米线的直径小于1um。 具有嵌入式纳米线的基板是不透液体的。 纳米线的近端适于连接到电子设备，并且远端适于设置在用于生物刺激靶组织和/或靶组织的生物感测活动的生物环境中。

    NANOSCALE SURFACE ACTIVATION OF SILICONE VIA LASER PROCESSING
    6.
    发明申请
    NANOSCALE SURFACE ACTIVATION OF SILICONE VIA LASER PROCESSING 审中-公开
    通过激光加工的硅胶的纳米表面活化

    公开(公告)号：US20080305320A1

    公开(公告)日：2008-12-11

    申请号：US12041652

    申请日：2008-03-03

    申请人： Lucien Laude ,  Adrian Rowley ,  Mark Humayun ,  James Weiland

    发明人： Lucien Laude ,  Adrian Rowley ,  Mark Humayun ,  James Weiland

    IPC分类号： B32B27/16

    CPC分类号： C08J7/123 ,  C08J2383/04 ,  Y10T428/249987

    摘要： The invention provides a method of activating a silicone polymer surface using a laser, particularly an excimer laser, so that the silicone is more reactive. A silicone article containing an activated surface is also provided, and can be used to make silicone implants that can be securely fixed to tissue. One example is an implantable prosthesis to treat blindness caused by outer retinal degenerative diseases. The device bypasses damaged photoreceptors and electrically stimulates the undamaged neurons of the retina. Electrical stimulation is achieved using a silicone microelectrode array (MEA). A safe, protein adhesive is used in attaching the MEA to the retinal surface and assist in alleviating focal pressure effects.

    摘要翻译： 本发明提供使用激光器，特别是准分子激光器激活硅氧烷聚合物表面的方法，使得硅氧烷更具反应性。 还提供了含活化表面的硅胶制品，可用于制造可固定固定在组织上的硅胶植入物。 一个例子是用于治疗由视网膜外变性疾病引起的失明的可植入假体。 该装置绕过受损的光感受器并电刺激视网膜的未损伤的神经元。 使用硅微电极阵列（MEA）实现电刺激。 使用安全的蛋白质粘合剂将MEA附着到视网膜表面并有助于减轻焦点压力的影响。