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公开(公告)号：US06476211B1
公开(公告)日：2002-11-05
申请号：US09557800
申请日：2000-04-25
申请人： John Ford , Julio J. Mulero , George Yeung
发明人： John Ford , Julio J. Mulero , George Yeung
IPC分类号： C07H2104
CPC分类号： C12N9/14 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/70596 , C12Q1/6883 , C12Q2600/158
摘要： The invention provides polynucleotides isolated from cDNA libraries of human fetal liver-spleen and macrophage as well as polypeptides encoded by these polynucleotides and mutants or variants thereof. The polypeptides correspond to a human CD39-like protein. Other aspects of the invention include vectors containing polynucleotides of the invention and related host cells as well a processes for producing CD39-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供从人胎儿肝脾和巨噬细胞的cDNA文库中分离的多核苷酸，以及由这些多核苷酸及其突变体或变体编码的多肽。 多肽对应于人CD39样蛋白。 本发明的其它方面包括含有本发明多核苷酸和相关宿主细胞的载体以及产生CD39样多肽的方法，以及对这些多肽具有特异性的抗体。
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公开(公告)号：US06447771B1
公开(公告)日：2002-09-10
申请号：US09370265
申请日：1999-08-09
申请人： John Ford , Julio J. Mulero , George Yeung
发明人： John Ford , Julio J. Mulero , George Yeung
IPC分类号： A61K3847
CPC分类号： C07K14/70596 , A01K2217/05 , A01K2217/075 , A61K38/00 , C12N9/14 , C12Q1/6883
摘要： The invention provides polynucleotides isolated from cDNA libraries of human fetal liver-spleen and macrophage as well as polypeptides encoded by these polynucleotides and mutants or variants thereof. The polypeptides correspond to a human CD39-like protein. Other aspects of the invention include vectors containing polynucleotides of the invention and related host cells as well a processes for producing CD39-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供从人胎儿肝脾和巨噬细胞的cDNA文库中分离的多核苷酸，以及由这些多核苷酸及其突变体或变体编码的多肽。 多肽对应于人CD39样蛋白。 本发明的其它方面包括含有本发明多核苷酸和相关宿主细胞的载体以及产生CD39样多肽的方法，以及对这些多肽具有特异性的抗体。
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公开(公告)号：US06335013B1
公开(公告)日：2002-01-01
申请号：US09608285
申请日：2000-06-30
申请人： John Ford , Julio J. Mulero , George Yeung
发明人： John Ford , Julio J. Mulero , George Yeung
IPC分类号： A61K3847
CPC分类号： C07K14/70596 , A01K2217/05 , A01K2217/075 , A61K38/00 , C12N9/14 , C12Q1/6883 , C12Q2600/158
摘要： The invention provides novel polynucleotides isolated from cDNA libraries of human fetal liver-spleen and macrophage as well as polypeptides encoded by these polynucleotides and mutants or variants thereof. The polypeptides correspond to a novel human CD39-like protein. Other aspects of the invention include vectors containing polynucleotides of the invention and related host cells as well a processes for producing novel CD39-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供从人胎儿肝脾和巨噬细胞的cDNA文库中分离的新型多核苷酸，以及由这些多核苷酸及其突变体或变体编码的多肽。 多肽对应于新的人CD39样蛋白。 本发明的其它方面包括含有本发明多核苷酸和相关宿主细胞的载体以及产生新型CD39样多肽的方法，以及对这些多肽具有特异性的抗体。
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公开(公告)号：US07001731B2
公开(公告)日：2006-02-21
申请号：US10101673
申请日：2002-03-18
申请人： John Ford , George Yeung
发明人： John Ford , George Yeung
CPC分类号： C07K14/7158
摘要： The invention provides novel polynucleotides isolated from cDNA libraries of human fetal liver-spleen and fetal liver as well as polypeptides encoded by these polynucleotides. The polypeptide is a human chemokine receptor that is a member of a family of G protein-coupled receptors characterized by seven transmembrane domains. Other aspects of the invention include vectors containing polynucleotides of the invention and related host cells as well a processes for producing chemokine receptor polypeptides, and antibodies specific for such polypeptides.
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5.发明授权公开(公告)号：US06472173B1
公开(公告)日：2002-10-29
申请号：US09409778
申请日：1999-09-22
申请人： John Ford , George Yeung
发明人： John Ford , George Yeung
IPC分类号： C12N1512
CPC分类号： C07K14/7158
摘要： The invention provides novel polynucleotides isolated from cDNA libraries of human fetal liver-spleen and fetal liver as well as polypeptides encoded by these polynucleotides. The polypeptide is a human chemokine receptor that is a member of a family of G protein-coupled receptors characterized by seven transmembrane domains. Other aspects of the invention include vectors containing polynucleotides of the invention and related host cells as well a processes for producing chemokine receptor polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供了从人胎儿肝脾和胎肝的cDNA文库中分离的新型多核苷酸以及由这些多核苷酸编码的多肽。 多肽是人类趋化因子受体，其是由七个跨膜结构域表征的G蛋白偶联受体家族的成员。 本发明的其它方面包括含有本发明多核苷酸和相关宿主细胞的载体以及用于产生趋化因子受体多肽的方法，以及对这些多肽具有特异性的抗体。
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公开(公告)号：US06392019B1
公开(公告)日：2002-05-21
申请号：US09363316
申请日：1999-07-28
申请人： John Ford , George Yeung
发明人： John Ford , George Yeung
IPC分类号： C07K200
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. In particular, the polypeptides of the invention comprise amino acid sequences with similarity to EGF-repeat domains.
摘要翻译： 本发明提供了由这些多核苷酸编码的新型多核苷酸和蛋白质，以及这些多核苷酸和蛋白质的治疗，诊断和研究用途。 特别地，本发明的多肽包含与EGF-重复结构域相似的氨基酸序列。
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7.发明授权公开(公告)号：US06392018B1
公开(公告)日：2002-05-21
申请号：US09249697
申请日：1999-02-12
申请人： John Ford , George Yeung
发明人： John Ford , George Yeung
IPC分类号： C07K1700
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. In particular, the polypeptides of the invention comprise amino acid sequences with similarity to EGF-repeat domains.
摘要翻译： 本发明提供了由这些多核苷酸编码的新型多核苷酸和蛋白质，以及这些多核苷酸和蛋白质的治疗，诊断和研究用途。 特别地，本发明的多肽包含与EGF-重复结构域相似的氨基酸序列。
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8.发明授权公开(公告)号：US06979548B2
公开(公告)日：2005-12-27
申请号：US10101148
申请日：2002-03-19
申请人： John Ford , George Yeung
发明人： John Ford , George Yeung
IPC分类号： C07K14/715 , C12N15/12 , G01N33/53 , C07K14/00 , C12N15/00 , C12N15/63 , G01N33/567
CPC分类号： C07K14/7158
摘要： The invention provides novel polynucleotides isolated from cDNA libraries of human fetal liver-spleen and fetal liver as well as polypeptides encoded by these polynucleotides. The polypeptide is a human chemokine receptor that is a member of a family of G protein-coupled receptors characterized by seven transmembrane domains. Other aspects of the invention include vectors containing polynucleotides of the invention and related host cells as well a processes for producing chemokine receptor polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供了从人胎儿肝脾和胎肝的cDNA文库中分离的新型多核苷酸以及由这些多核苷酸编码的多肽。 多肽是人类趋化因子受体，其是由七个跨膜结构域表征的G蛋白偶联受体家族的成员。 本发明的其它方面包括含有本发明多核苷酸和相关宿主细胞的载体以及用于产生趋化因子受体多肽的方法，以及对这些多肽具有特异性的抗体。
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9.发明申请公开(公告)号：US20050222393A1
公开(公告)日：2005-10-06
申请号：US10101673
申请日：2002-03-18
申请人： John Ford , George Yeung
发明人： John Ford , George Yeung
IPC分类号： C07K14/715 , C12N15/12 , G01N33/53 , C07K16/28 , G01N33/567
CPC分类号： C07K14/7158
摘要： The invention provides novel polynucleotides isolated from cDNA libraries of human fetal liver-spleen and fetal liver as well as polypeptides encoded by these polynucleotides. The polypeptide is a human chemokine receptor that is a member of a family of G protein-coupled receptors characterized by seven transmembrane domains. Other aspects of the invention include vectors containing polynucleotides of the invention and related host cells as well a processes for producing chemokine receptor polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供了从人胎儿肝脾和胎肝的cDNA文库中分离的新型多核苷酸以及由这些多核苷酸编码的多肽。 多肽是人类趋化因子受体，其是由七个跨膜结构域表征的G蛋白偶联受体家族的成员。 本发明的其它方面包括含有本发明多核苷酸和相关宿主细胞的载体以及用于产生趋化因子受体多肽的方法，以及对这些多肽具有特异性的抗体。
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公开(公告)号：US20110281738A1
公开(公告)日：2011-11-17
申请号：US13098965
申请日：2011-05-02
CPC分类号： C12Q1/6837 , C12N15/1093 , C12Q1/682 , C12Q1/6869 , C12Q1/6874 , C12Q2531/125 , C12Q2525/313 , C12Q2525/151 , C12Q2521/313 , C12Q2565/513 , C12Q2521/307
摘要： The present invention provides methods of making and using self-assembled arrays of single polynucleotide molecules for carrying out a variety of large-scale genetic measurements, such as gene expression analysis, gene copy number assessment, and the like. Random arrays used in the invention are “self-assembled” in the sense that they are formed by deposition of polynucleotide molecules onto a surface where they become fixed at random locations. The polynucleotide molecules fixed on the surface are then identified by direct sequence determination of component nucleic acids, such as incorporated probe sequences, or by other decoding schemes. Such identification converts a random array of determinable polynucleotides, and their respective probes into an addressable array of probe sequences.
摘要翻译： 本发明提供制造和使用单个多核苷酸分子的自组装阵列进行各种大规模遗传测量的方法，例如基因表达分析，基因拷贝数评估等。 在本发明中使用的随机阵列是“自组装”的意思，即它们通过将多核苷酸分子沉积到其随机位置固定的表面上而形成。 然后通过直接序列测定组分核酸，例如并入的探针序列或其他解码方案来鉴定固定在表面上的多核苷酸分子。 这种鉴定将随机阵列的可测定多核苷酸及其各自的探针转换成可寻址的探针序列阵列。
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