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    Process for treating hard tissues
    1.
    发明授权
    Process for treating hard tissues 有权
    硬组织治疗方法

    公开(公告)号：US6159012A

    公开(公告)日：2000-12-12

    申请号：US387449

    申请日：1999-09-01

    申请人： Joel D. Oxman ,  Hoa T. Bui ,  Dwight W. Jacobs

    发明人： Joel D. Oxman ,  Hoa T. Bui ,  Dwight W. Jacobs

    IPC分类号： A61K6/00 ,  A61K6/083 ,  A61K6/087 ,  A61B17/06 ,  A61C5/00 ,  A61K6/08 ,  C08L63/00

    CPC分类号： A61K6/0023 ,  Y10S522/908

    摘要： In a first aspect, a method for treating hard tissue that includes: (a) applying to hard tissue a composition that includes a cationically active functional group, a free radically active functional group, and a polymerization initiator capable of initiating free radical polymerization, where the number of moles of cationically active functional groups per gram of composition is no greater than about 0.0075; and (b) exposing the composition to polymerization conditions to form an adhesive bonded to the hard tissue.In a second aspect, a method for treating hard tissue that includes: (a) applying to hard tissue a first polymerizable composition that includes a free radically active functional group and a polymerization initiator capable of initiating free radical polymerization, but is essentially free of polymerizable components having cationically active functional groups and is capable of forming an adhesive bonded to the hard tissue upon exposure to polymerization conditions; (b) applying a second polymerizable composition; and (c) exposing the second composition to polymerization conditions to form a hardened composition adhered to the hard tissue. The second composition includes (i) a cationically active functional group and (ii) an polymerization initiator capable of initiating cationic polymerization.

    摘要翻译： 第一方面，一种硬组织处理方法，包括：（a）向硬组织施加包含阳离子活性官能团，自由基活性官能团和能引发自由基聚合的聚合引发剂的组合物，其中 每克组合物中阳离子活性官能团的摩尔数不大于约0.0075; 和（b）将组合物暴露于聚合条件以形成粘合到硬组织的粘合剂。 在第二方面，一种硬组织处理方法，包括：（a）向硬组织施加包含自由基活性官能团的第一可聚合组合物和能引发自由基聚合的聚合引发剂，但基本上不含可聚合的 具有阳离子活性官能团的组分并且能够在暴露于聚合条件时形成粘合到硬组织的粘合剂; （b）施加第二可聚合组合物; 和（c）将第二组合物暴露于聚合条件以形成粘附到硬组织的硬化组合物。 第二组合物包括（i）阳离子活性官能团和（ii）能够引发阳离子聚合的聚合引发剂。

    Process for treating hard tissues
    2.
    发明授权
    Process for treating hard tissues 失效

    公开(公告)号：US5980253A

    公开(公告)日：1999-11-09

    申请号：US5885

    申请日：1998-01-12

    申请人： Joel D. Oxman ,  Hoa T. Bui ,  Dwight W. Jacobs

    发明人： Joel D. Oxman ,  Hoa T. Bui ,  Dwight W. Jacobs

    IPC分类号： A61K6/00 ,  A61K6/083 ,  A61K6/087 ,  A61B17/06 ,  A61C5/00 ,  A61K6/08 ,  C08L63/00

    CPC分类号： A61K6/0023 ,  Y10S522/908

    摘要： In a first aspect, a method for treating hard tissue that includes: (a) applying to hard tissue a composition that includes a cationically active functional group, a free radically active functional group, and a polymerization initiator capable of initiating free radical polymerization, where the number of moles of cationically active functional groups per gram of composition is no greater than about 0.0075; and (b) exposing the composition to polymerization conditions to form an adhesive bonded to the hard tissue.In a second aspect, a method for treating hard tissue that includes: (a) applying to hard tissue a first polymerizable composition that includes a free radically active functional group and a polymerization initiator capable of initiating free radical polymerization, but is essentially free of polymerizable components having cationically active functional groups and is capable of forming an adhesive bonded to the hard tissue upon exposure to polymerization conditions; (b) applying a second polymerizable composition; and (c) exposing the second composition to polymerization conditions to form a hardened composition adhered to the hard tissue. The second composition includes (i) a cationically active functional group and (ii) an polymerization initiator capable of initiating cationic polymerization.

    Dental compositions comprising ethylenically unsaturated addition-fragmentation agent
    5.
    发明授权
    Dental compositions comprising ethylenically unsaturated addition-fragmentation agent 有权
    含有烯键式不饱和加成断裂剂的牙科组合物

    公开(公告)号：US09056043B2

    公开(公告)日：2015-06-16

    申请号：US13978557

    申请日：2012-02-08

    申请人： Guy D. Joly ,  Larry R. Krepski ,  Babu N. Gaddam ,  Ahmed S. Abuelyaman ,  Bradley D. Craig ,  Timothy D. Dunbar ,  Chuntao Cao ,  Joel D. Oxman ,  Afshin Falsafi ,  William H. Moser ,  Hoa T. Bui

    发明人： Guy D. Joly ,  Larry R. Krepski ,  Babu N. Gaddam ,  Ahmed S. Abuelyaman ,  Bradley D. Craig ,  Timothy D. Dunbar ,  Chuntao Cao ,  Joel D. Oxman ,  Afshin Falsafi ,  William H. Moser ,  Hoa T. Bui

    IPC分类号： A61K6/083 ,  A61K6/00

    CPC分类号： A61K6/083 ,  A61K6/0023 ,  A61K6/0029 ,  A61K6/005 ,  C08L33/10

    摘要： Dental compositions are described comprising an addition-fragmentation agent comprising at least one ethylenically unsaturated terminal group and a backbone unit comprising an α,β-unsaturated carbonyl; at least one monomer comprising at least two ethylenically unsaturated group; and inorganic oxide filler. The addition-fragmentation agent is preferably free-radically cleavable. The addition-fragmentation agent preferably comprises at least two ethylenically unsaturated terminal groups, such as (meth)acTylate groups. In some embodiments, the addition-fragmentation agent has the formula: wherein R1, R2 and R3 are each independently Zm, -Q-, a (hetero)alkyl group or a (hetero)aryl group with the proviso that at least one of R1, R2 and R3 is Zm-Q-; Q is a linking group have a valence of m+1; Z is an ethylenically unsaturated polymerizable group; m is 1 to 6; each X1 is independently —O— or —NR4—, where R4 is H or C1-C4 alkyl; and n is 0 or 1. Also described are dental articles prepared from a dental composition comprising an addition-fragmentation agent and methods of treating a tooth surface.

    摘要翻译： 描述了牙科组合物，其包含包含至少一个烯属不饱和末端基团的加成断裂剂和包含α，β-不饱和羰基的主链单元; 至少一种包含至少两个烯属不饱和基团的单体; 和无机氧化物填料。 加成裂解剂优选是可自由基切割的。 加成断裂剂优选包含至少两个烯键式不饱和端基，例如（甲基）丙烯酸酯基团。 在一些实施方案中，加成断裂剂具有下式：其中R 1，R 2和R 3各自独立地为Z m，-Q-，（杂）烷基或（杂）芳基，条件是R 1 ，R2和R3是Zm-Q-; Q是连接基团，其价态为m + 1; Z是烯属不饱和可聚合基团; m为1〜6; 每个X 1独立地是-O-或-NR 4 - ，其中R 4是H或C 1 -C 4烷基; 并且n为0或1.还描述了由包含加成碎裂剂的牙科组合物制备的牙科用品和治疗牙齿表面的方法。

    DENTAL COMPOSITIONS COMPRISING ETHYLENICALLY UNSATURATED ADDITION-FRAGMENTATION AGENT
    7.
    发明申请
    DENTAL COMPOSITIONS COMPRISING ETHYLENICALLY UNSATURATED ADDITION-FRAGMENTATION AGENT 有权
    包含乙烯不饱和添加剂分散剂的牙科组合物

    公开(公告)号：US20130316307A1

    公开(公告)日：2013-11-28

    申请号：US13978557

    申请日：2012-02-08

    申请人： Guy D. Joly ,  Larry R. Krepski ,  Babu N. Gaddam ,  Ahmed S. Abuelyaman ,  Bradley D. Craig ,  Timothy D. Dunbar ,  Chuntao Cao ,  Joel D. Oxman ,  Afshin Falsafi ,  William H. Moser ,  Hoa T. Bui

    发明人： Guy D. Joly ,  Larry R. Krepski ,  Babu N. Gaddam ,  Ahmed S. Abuelyaman ,  Bradley D. Craig ,  Timothy D. Dunbar ,  Chuntao Cao ,  Joel D. Oxman ,  Afshin Falsafi ,  William H. Moser ,  Hoa T. Bui

    IPC分类号： A61K6/00

    CPC分类号： A61K6/083 ,  A61K6/0023 ,  A61K6/0029 ,  A61K6/005 ,  C08L33/10

    摘要： Dental compositions are described comprising an addition-fragmentation agent comprising at least one ethylenically unsaturated terminal group and a backbone unit comprising an α,β-unsaturated carbonyl; at least one monomer comprising at least two ethylenically unsaturated group; and inorganic oxide filler. The addition-fragmentation agent is preferably free-radically cleavable. The addition-fragmentation agent preferably comprises at least two ethylenically unsaturated terminal groups, such as (meth)acTylate groups. In some embodiments, the addition-fragmentation agent has the formula: wherein R1, R2 and R3 are each independently Zm, -Q-, a (hetero)alkyl group or a (hetero)aryl group with the proviso that at least one of R1, R2 and R3 is Zm-Q-; Q is a linking group have a valence of m+1; Z is an ethylenically unsaturated polymerizable group; m is 1 to 6; each X1 is independently —O— or —NR4—, where R4 is H or C1-C4 alkyl; and n is 0 or 1. Also described are dental articles prepared from a dental composition comprising an addition-fragmentation agent and methods of treating a tooth surface.

    摘要翻译： 描述了牙科组合物，其包含包含至少一个烯属不饱和末端基团的加成断裂剂和包含α，β-不饱和羰基的主链单元; 至少一种包含至少两个烯属不饱和基团的单体; 和无机氧化物填料。 加成裂解剂优选是可自由基切割的。 加成断裂剂优选包含至少两个烯键式不饱和端基，例如（甲基）丙烯酸酯基团。 在一些实施方案中，加成断裂剂具有下式：其中R 1，R 2和R 3各自独立地为Z m，-Q-，（杂）烷基或（杂）芳基，条件是R 1 ，R2和R3是Zm-Q-; Q是连接基团，其价态为m + 1; Z是烯属不饱和可聚合基团; m为1〜6; 每个X 1独立地是-O-或-NR 4 - ，其中R 4是H或C 1 -C 4烷基; 并且n为0或1.还描述了由包含加成碎裂剂的牙科组合物制备的牙科用品和治疗牙齿表面的方法。

    DENTAL AUTO-MIXING METHOD, DEVICE, AND COMPOSITION FOR TEMPORARY CEMENTS
    8.
    发明申请
    DENTAL AUTO-MIXING METHOD, DEVICE, AND COMPOSITION FOR TEMPORARY CEMENTS 审中-公开
    牙科自动混合方法，装置和组合物用于临时试验

    公开(公告)号：US20120258424A1

    公开(公告)日：2012-10-11

    申请号：US13513879

    申请日：2010-12-16

    申请人： Afshin Falsafi ,  Joel D. Oxman ,  Hoa T. Bui ,  Anupa N. Patel

    发明人： Afshin Falsafi ,  Joel D. Oxman ,  Hoa T. Bui ,  Anupa N. Patel

    IPC分类号： A61K6/083 ,  A61C13/263 ,  A61C5/06 ,  A61C13/23

    CPC分类号： A61K6/083 ,  A61C5/62 ,  A61C5/64 ,  A61K6/0017 ,  A61K6/0023 ,  A61K6/0835 ,  C08L33/00

    摘要： The abstract has been amended as follows: A method of dispensing a hardenable dental composition, which can form a temporary bond, comprising 1) providing multi-part hardenable dental composition comprising part (A) in the form of a paste comprising acid-reactive glass particles and a liquid selected from the group consisting of water, a monomer having at least one ethylenically 10 unsaturated group per monomer molecule, and a combination thereof; and part (B) comprising a water soluble polyacid and a liquid selected from the group consisting of water, a monomer having at least one ethylenically unsaturated group per monomer molecule, and a combination thereof; and 2) extruding the composition through a static mixer in fluid communication with a first reservoir containing the part (A) and a second reservoir 20 containing the part (B); wherein a plunger is positioned in each reservoir for simultaneously forcing part (A) and part (B) into the static mixer.

    摘要翻译： 摘要已经被修改如下：一种分配可以形成临时结合的可硬化牙科组合物的方法，包括：1）提供多部分可硬化牙科用组合物，其包含含有酸反应性玻璃的浆料形式的部分（A） 颗粒和选自水，每单体分子具有至少一个烯键式10不饱和基团的单体及其组合的液体; 和部分（B），其包含水溶性多酸和选自水，每单体分子具有至少一个烯属不饱和基团的单体及其组合的液体; 和2）通过与包含所述部分（A）的第一储存器和包含所述部分（B）的第二储存器20流体连通的静态混合器挤出所述组合物; 其中柱塞位于每个储存器中，用于同时迫使部分（A）和部分（B）进入静态混合器。