摘要:
The present invention relates to a novel class of supermolecular carboplatin derivatives represented by general formula (I), wherein B is a polycarboxylic acid represented by general formula (II), wherein R1, R2 and n are defined as in the description. The present invention also relates to a process for preparing the same, pharmaceutical compositions containing the same as active ingredient and the use of the derivatives in the preparation of pharmaceutical compositions which are useful in treating various cellular cancers including hepatoma, stomach cancer, lung cancer and the like. The derivatives have stable cage-like chemical structures and constitutions in solid and in aqueous solution. The derivatives can not only kill cancer cells at a rate significantly higher than that by carboplatin, in particular, in the case of hepatoma cells, at a rate one to two times higher than that by carboplatin, but also produce little side effects such as vomit, baldness, decreases of leucocytes and platelets, and the like, which can be induced by administration of other chemotherapeutics. In the acute toxicity tests on mice, the lethal dose (LD50) of the present derivatives is about 300 mg/kg and 260 mg/kg body weight for a subcutaneous(sc) and an intraperitoneal(ip) administration, respectively. Therefore, the present derivatives are a novel class of cis-platium which can be widely used as anticancer agents.
摘要:
The present invention relates to a novel class of supermolecular carboplatin derivatives represented by general formula (I), wherein B is a polycarboxylic acid represented by general formula (II), wherein R1, R2 and n are defined as in the description. The present invention also relates to a process for preparing the same, pharmaceutical compositions containing the same as active ingredient and the use of the derivatives in the preparation of pharmaceutical compositions which are useful in treating various cellular cancers including hepatoma, stomach cancer, lung cancer and the like. The derivatives have stable cage-like chemical structures and constitutions in solid and in aqueous solution. The derivatives can not only kill cancer cells at a rate significantly higher than that by carboplatin, in particular, in the case of hepatoma cells, at a rate one to two times higher than that by carboplatin, but also produce little side effects such as vomit, baldness, decreases of leucocytes and platelets, and the like, which can be induced by administration of other chemotherapeutics. In the acute toxicity tests on mice, the lethal dose (LD50) of the present derivatives is about 300 mg/kg and 260 mg/kg body weight for a subcutaneous(sc) and an intraperitoneal(ip) administration, respectively. Therefore, the present derivatives are a novel class of cis-platium which can be widely used as anticancer agents.
摘要:
FIG. 1 is a front view of a smart fish tank showing my new design; FIG. 2 is a rear view thereof; FIG. 3 is a right side view thereof; FIG. 4 is a left side view thereof; FIG. 5 is a top plan view thereof; FIG. 6 is a bottom plan view thereof; and, FIG. 7 is a perspective view thereof. The broken lines in the drawings depict portions of the smart fish tank and form no part of the claimed design.
摘要:
Provided is a leak-proof lubrication system for a power device, comprising an oil supply pump inlet pipe, an oil supply pump, an oil supply pressure gauge, an oil supply pump outlet pipe, an oil supply filter, a lubricating oil, an oil storage tank, an oil return pipe, an storage tank pressure gauge, a vacuum pump intake pipe, a vacuum pump inlet air filter, a vacuum pump and a vacuum pump exhaust pipe. The system employs a negative pressure operation method in which the pressure of the lubrication system is controlled to be lower than the outside ambient pressure, which allows a small amount of air to flow from the outside to the inside of the lubrication system along with the lubricant to return to the storage tank, preventing leakage of the lubricant from connection joints. It is suitable to be used for gas turbines or other high-speed power machines.
摘要:
An optical transport network based on multimode/multicore fibers includes a mode-multiplexer to multiplex independent data streams from one or more transmitters; a multimode erbium-doped fiber amplifier (MM EDFA) to compensate for MMF loss; a multimode optical add-drop multiplexer (MM OADM) to add and/or drop multimode channels in multimode networks; a multimode optical cross-connect; and a mode-demultiplexer to separate various mode streams to one or more receivers.
摘要:
A method for generating a 400 Gb/s single channel optical signal from multiple modulated subchannels includes carving respective modulated subchannels into return-to-zero RZ modulated subchannels having non-overlapping peaks with intensity modulators having a duty cycle less than 50%, and combining the subchannels into a single channel signal aggregating the bit rate of each of the subchannels. The subchannels are combined with a flat top optical component for increased subsequent receiver sensitivity.
摘要:
A method for optical layer traffic grooming includes receiving at least two optical input signals into respective optical receivers, each optical receiver having a photodetector for converting the respective optical input signal into a respective electrical signal; a grooming processor responsive to the electrical signals, the grooming processor being a radio frequency RF processor for processing the electrical signals at a subcarrier level to produce an RF orthogonal frequency division multiplexing signal OFDM signal; and modulating the groomed RF OFDM signal at a transmitter for conversion of the groomed RF OFDM into an optical signal.
摘要:
The present invention employs a look up table based implementation for the metric computations which eliminate redundancy and substantially reduce the number of multiplications. Moreover, inventive method exploits the fact that the un-normalized constellation symbols are complex integers so that the product of a real-number and an un-normalized constellation symbol can be implemented by only additions. The inventive method also enables a greater efficiency for whitening colored noise prior to demodulation, one of which involves no square-root operation. The invention results in less complexity, faster operation, lower power consumption, without sacrificing performance.
摘要:
An optical transmitter includes a dividing optical coupler, a first optical modulator driven by an I component of a first signal and a I component of a second signal for modulating a lightwave, a DC bias of the first optical, a second optical modulator driven by a Q component of the first signal and a Q component of the second signal for modulating a lightwave, a DC bias of the second optical modulator, a phase shifter, and a combining optical coupler for combining the modulated lightwave from the first optical coupler and the phase shifted Q components of the first and second signals for generating a quadrature amplitude modulated signal.