Supermolecular carboplatinum derivatives, their preparation and pharmaceutical composition containing tem as active ingredient and applications of the compositions
    1.
    发明申请
    Supermolecular carboplatinum derivatives, their preparation and pharmaceutical composition containing tem as active ingredient and applications of the compositions 失效
    超分子卡铂衍生物,其制备方法和药物组合物含有作为活性成分的组合物和组合物的应用

    公开(公告)号:US20050165093A1

    公开(公告)日:2005-07-28

    申请号:US10497081

    申请日:2001-11-30

    CPC分类号: C07F15/0093

    摘要: The present invention relates to a novel class of supermolecular carboplatin derivatives represented by general formula (I), wherein B is a polycarboxylic acid represented by general formula (II), wherein R1, R2 and n are defined as in the description. The present invention also relates to a process for preparing the same, pharmaceutical compositions containing the same as active ingredient and the use of the derivatives in the preparation of pharmaceutical compositions which are useful in treating various cellular cancers including hepatoma, stomach cancer, lung cancer and the like. The derivatives have stable cage-like chemical structures and constitutions in solid and in aqueous solution. The derivatives can not only kill cancer cells at a rate significantly higher than that by carboplatin, in particular, in the case of hepatoma cells, at a rate one to two times higher than that by carboplatin, but also produce little side effects such as vomit, baldness, decreases of leucocytes and platelets, and the like, which can be induced by administration of other chemotherapeutics. In the acute toxicity tests on mice, the lethal dose (LD50) of the present derivatives is about 300 mg/kg and 260 mg/kg body weight for a subcutaneous(sc) and an intraperitoneal(ip) administration, respectively. Therefore, the present derivatives are a novel class of cis-platium which can be widely used as anticancer agents.

    摘要翻译: 本发明涉及由通式(I)表示的新一类超分子卡铂衍生物,其中B是由通式(II)表示的多元羧酸,其中R 1,R 2 < / SUB>和n如在说明书中所定义。 本发明还涉及其制备方法,其含有与活性成分相同的药物组合物和该衍生物在制备药物组合物中的用途,所述药物组合物可用于治疗各种细胞癌,包括肝癌,胃癌,肺癌和 类似。 该衍生物在固体和水溶液中具有稳定的笼状化学结构和结构。 衍生物不仅可以以比卡铂显着更高的速率杀死癌细胞,特别是在肝癌细胞的情况下,其比率高于卡铂的一至二倍,而且还产生很少的副作用,例如呕吐 ,秃发,白细胞和血小板的减少等,其可以通过施用其它化学治疗剂诱导。 在对小鼠的急性毒性试验中,本发明衍生物的致死剂量(LD 50 N)为皮下(sc)和腹膜内(ip)为约300mg / kg和260mg / kg体重 )管理。 因此,本发明的衍生物是可广泛用作抗癌剂的新型顺铂。

    Supermolecular carboplatin derivatives, their preparation and pharmaceutical composition containing them as active ingredient and applications of the compositions
    2.
    发明授权
    Supermolecular carboplatin derivatives, their preparation and pharmaceutical composition containing them as active ingredient and applications of the compositions 失效
    超分子卡铂衍生物,其制备方法和药物组合物含有它们作为活性成分和组合物的应用

    公开(公告)号:US07259270B2

    公开(公告)日:2007-08-21

    申请号:US10497081

    申请日:2001-11-30

    IPC分类号: C07F15/00 A61K31/28

    CPC分类号: C07F15/0093

    摘要: The present invention relates to a novel class of supermolecular carboplatin derivatives represented by general formula (I), wherein B is a polycarboxylic acid represented by general formula (II), wherein R1, R2 and n are defined as in the description. The present invention also relates to a process for preparing the same, pharmaceutical compositions containing the same as active ingredient and the use of the derivatives in the preparation of pharmaceutical compositions which are useful in treating various cellular cancers including hepatoma, stomach cancer, lung cancer and the like. The derivatives have stable cage-like chemical structures and constitutions in solid and in aqueous solution. The derivatives can not only kill cancer cells at a rate significantly higher than that by carboplatin, in particular, in the case of hepatoma cells, at a rate one to two times higher than that by carboplatin, but also produce little side effects such as vomit, baldness, decreases of leucocytes and platelets, and the like, which can be induced by administration of other chemotherapeutics. In the acute toxicity tests on mice, the lethal dose (LD50) of the present derivatives is about 300 mg/kg and 260 mg/kg body weight for a subcutaneous(sc) and an intraperitoneal(ip) administration, respectively. Therefore, the present derivatives are a novel class of cis-platium which can be widely used as anticancer agents.

    摘要翻译: 本发明涉及由通式(I)表示的新一类超分子卡铂衍生物,其中B是由通式(II)表示的多元羧酸,其中R 1,R 2 < / SUB>和n如在说明书中所定义。 本发明还涉及其制备方法,其含有与活性成分相同的药物组合物和该衍生物在制备药物组合物中的用途,所述药物组合物可用于治疗各种细胞癌,包括肝癌,胃癌,肺癌和 类似。 该衍生物在固体和水溶液中具有稳定的笼状化学结构和结构。 衍生物不仅可以以比卡铂显着更高的速率杀死癌细胞,特别是在肝癌细胞的情况下,其比率高于卡铂的一至二倍,而且还产生很少的副作用,例如呕吐 ,秃发,白细胞和血小板的减少等,其可以通过施用其它化学治疗剂诱导。 在对小鼠的急性毒性试验中,本发明衍生物的致死剂量(LD 50 N)为皮下(sc)和腹膜内(ip)为约300mg / kg和260mg / kg体重 )管理。 因此,本发明的衍生物是可广泛用作抗癌剂的新型顺铂。

    Smart fish tank
    3.
    外观设计

    公开(公告)号:USD1019003S1

    公开(公告)日:2024-03-19

    申请号:US29823396

    申请日:2022-01-17

    申请人: Ting Wang

    设计人: Ting Wang

    摘要: FIG. 1 is a front view of a smart fish tank showing my new design;
    FIG. 2 is a rear view thereof;
    FIG. 3 is a right side view thereof;
    FIG. 4 is a left side view thereof;
    FIG. 5 is a top plan view thereof;
    FIG. 6 is a bottom plan view thereof; and,
    FIG. 7 is a perspective view thereof.
    The broken lines in the drawings depict portions of the smart fish tank and form no part of the claimed design.

    Smart fish tank
    4.
    外观设计

    公开(公告)号:USD953651S1

    公开(公告)日:2022-05-31

    申请号:US29768677

    申请日:2021-01-31

    申请人: Ting Wang

    设计人: Ting Wang

    Generating a 400-Gbit/s single-channel optical signal
    7.
    发明授权
    Generating a 400-Gbit/s single-channel optical signal 有权
    生成400 Gbit / s单通道光信号

    公开(公告)号:US08873970B2

    公开(公告)日:2014-10-28

    申请号:US12789943

    申请日:2010-05-28

    CPC分类号: H04B10/548 H04J14/06

    摘要: A method for generating a 400 Gb/s single channel optical signal from multiple modulated subchannels includes carving respective modulated subchannels into return-to-zero RZ modulated subchannels having non-overlapping peaks with intensity modulators having a duty cycle less than 50%, and combining the subchannels into a single channel signal aggregating the bit rate of each of the subchannels. The subchannels are combined with a flat top optical component for increased subsequent receiver sensitivity.

    摘要翻译: 用于从多个调制子信道生成400Gb / s单信道光信号的方法包括将具有非重叠峰值的相应调制子信道刻蚀成具有占空比小于50%的强度调制器的归零至零RZ调制子信道,以及组合 将子信道转换成单个信道信号,聚合每个子信道的比特率。 子通道与平顶光学部件组合,以增加后续的接收灵敏度。

    Optical-layer traffic grooming at an OFDM subcarrier level with photodetection conversion of an input optical OFDM to an electrical signal
    8.
    发明授权
    Optical-layer traffic grooming at an OFDM subcarrier level with photodetection conversion of an input optical OFDM to an electrical signal 有权
    在OFDM子载波电平处的光层业务整合,其中输入光OFDM的光检测转换为电信号

    公开(公告)号:US08787762B2

    公开(公告)日:2014-07-22

    申请号:US13402418

    申请日:2012-02-22

    IPC分类号: H04J14/02

    CPC分类号: H04J14/0212 H04J14/0298

    摘要: A method for optical layer traffic grooming includes receiving at least two optical input signals into respective optical receivers, each optical receiver having a photodetector for converting the respective optical input signal into a respective electrical signal; a grooming processor responsive to the electrical signals, the grooming processor being a radio frequency RF processor for processing the electrical signals at a subcarrier level to produce an RF orthogonal frequency division multiplexing signal OFDM signal; and modulating the groomed RF OFDM signal at a transmitter for conversion of the groomed RF OFDM into an optical signal.

    摘要翻译: 一种用于光层流量梳理的方法包括:将至少两个光输入信号接收到相应的光接收器中,每个光接收器具有用于将相应的光输入信号转换成相应的电信号的光电检测器; 一个整理处理器,响应于电信号,整修处理器是一个射频RF处理器,用于处理子载波电平的电信号,以产生一个RF正交频分复用信号OFDM信号; 以及在发射机处调制经修整的RF OFDM信号,以将整修的RF OFDM转换成光信号。

    Efficient square-root free 2 symbol max-log receiver
    9.
    发明授权
    Efficient square-root free 2 symbol max-log receiver 有权
    高效的平方根自由2符号最大对数接收器

    公开(公告)号:US08767888B2

    公开(公告)日:2014-07-01

    申请号:US13433873

    申请日:2012-03-29

    摘要: The present invention employs a look up table based implementation for the metric computations which eliminate redundancy and substantially reduce the number of multiplications. Moreover, inventive method exploits the fact that the un-normalized constellation symbols are complex integers so that the product of a real-number and an un-normalized constellation symbol can be implemented by only additions. The inventive method also enables a greater efficiency for whitening colored noise prior to demodulation, one of which involves no square-root operation. The invention results in less complexity, faster operation, lower power consumption, without sacrificing performance.

    摘要翻译: 本发明使用用于度量计算的查找表实现,其消除冗余并且显着减少乘法次数。 此外,本发明的方法利用了未归一化的星座符号是复数整数的事实,使得实数和未归一化的星座符号的乘积可以仅通过添加来实现。 本发明的方法还使得能够在解调之前增加有色噪声的效率,其中之一不涉及平方根操作。 本发明导致更少的复杂性,更快的操作,更低的功耗,而不会牺牲性能。

    16 quadrature amplitude modulation optical signal transmitter
    10.
    发明授权
    16 quadrature amplitude modulation optical signal transmitter 有权
    16正交幅度调制光信号发射机

    公开(公告)号:US08761612B2

    公开(公告)日:2014-06-24

    申请号:US12562260

    申请日:2009-09-18

    IPC分类号: H04B10/00

    CPC分类号: H04B10/5053 H04B10/541

    摘要: An optical transmitter includes a dividing optical coupler, a first optical modulator driven by an I component of a first signal and a I component of a second signal for modulating a lightwave, a DC bias of the first optical, a second optical modulator driven by a Q component of the first signal and a Q component of the second signal for modulating a lightwave, a DC bias of the second optical modulator, a phase shifter, and a combining optical coupler for combining the modulated lightwave from the first optical coupler and the phase shifted Q components of the first and second signals for generating a quadrature amplitude modulated signal.

    摘要翻译: 光发射机包括分光光耦合器,由第一信号的I分量驱动的第一光调制器和用于调制光波的第二信号的I分量,第一光学器件的DC偏置,第二光调制器驱动的第二光调制器 第一信号的Q分量和用于调制光波的第二信号的Q分量,第二光调制器的DC偏置,移相器和组合光耦合器,用于组合来自第一光耦合器的调制光波和相位 用于产生正交幅度调制信号的第一和第二信号的移位Q分量。