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    Methods and compositions for cell therapy
    7.
    发明申请
    Methods and compositions for cell therapy 审中-公开
    细胞治疗方法和组成

    公开(公告)号：US20090136464A1

    公开(公告)日：2009-05-28

    申请号：US12218045

    申请日：2008-07-09

    Applicant: Jose Cibelli ,  Tanja Dominko

    Inventor： Jose Cibelli ,  Tanja Dominko

    IPC: A61K35/12 ,  A61P43/00

    CPC classification number: A01K67/0271 ,  A01K2217/05 ,  A61K35/12 ,  A61K48/00 ,  C12N15/873 ,  C12N2517/02 ,  C12N2517/04

    Abstract: Improved methods of cell therapy are provided using cells and tissues that are histocompatible with a human or non-human transplant recipient. The cells and tissues for transplant produced by the present invention exhibit a youthful state and can be committed to specific cell lineages to better infiltrate and proliferate at a desired target, e.g., a tissue, or organ in need of cell replacement therapy. For providing cells and tissues for transplant to a non-human mammal, the cells and tissues can be isolated from a gastrulating embryo produced by same-species nuclear transfer. Histocompatible cells and tissues for transplant to a human can be isolated from a gastrulating embryo that (i) is genetically modified to be in capable of developing beyond an early stage, or (ii) is produced by cross-species nuclear transfer between a human nuclear donor cell and an enucleated recipient cell, e.g., an oocyte, of a non-human mammal, or (iii) is produced by androgenesis or gynogenesis, or from pluripotent stem cells generated from such an embryo. Methods for producing histocompatible cells and tissues for transplant to a human can also be used to produce such cells or tissues for transplant to non-human mammals. The present invention also provides model embryonic systems having defined genetic makeup that are useful for developing and testing methods for cell and tissue therapy, and for studying genetic imprinting, reprogramming, rejuvenation, and other biochemical, metabolic, and physiological phenomena associated with embryogenesis.

    Abstract translation: 使用与人或非人类移植受体组织相容的细胞和组织提供改进的细胞治疗方法。 本发明生产的用于移植的细胞和组织表现出年轻状态，并且可以致力于特定的细胞谱系，以在期望的靶，例如需要细胞替代疗法的组织或器官中更好地渗透和增殖。 为了提供用于移植到非人哺乳动物的细胞和组织，细胞和组织可以从通过相同种类的核转移产生的诱导胚胎中分离出来。 用于移植到人中的组织相容的细胞和组织可以从一个起胚胚胎中分离出来，（i）经过基因修饰以能够在早期阶段发育，或（ii）通过人类核之间的跨物种核转移产生 供体细胞和去核的受体细胞，例如非人哺乳动物的卵母细胞，或（iii）通过雄激素或雌激素产生，或由这种胚胎产生的多能干细胞产生。 用于生产用于移植到人中的组织相容性细胞和组织的方法也可以用于产生用于移植到非人哺乳动物的这种细胞或组织。 本发明还提供具有确定的遗传构成的模型胚胎系统，其可用于细胞和组织治疗的开发和测试方法，以及用于研究与胚胎发生相关的遗传印记，重编程，复壮和其他生物化学，代谢和生理现象。

    Methods and compositions for cell therapy
    9.
    发明申请
    Methods and compositions for cell therapy 审中-公开
    细胞治疗方法和组成

    公开(公告)号：US20060083722A1

    公开(公告)日：2006-04-20

    申请号：US10484398

    申请日：2002-01-25

    Applicant: Jose Cibelli ,  Tanja Dominko

    Inventor： Jose Cibelli ,  Tanja Dominko

    IPC: A61K48/00 ,  C12N5/08

    CPC classification number: A01K67/0271 ,  A01K2217/05 ,  A61K35/12 ,  A61K48/00 ,  C12N15/873 ,  C12N2517/02 ,  C12N2517/04

    Abstract: Improved methods of cell therapy are provided using cells and tissues that are histocompatible with a human or non-human mammal transplant recipient. The cells and tissues for transplant produced by the present invention exhibit a youthful state and can be committed to specific cell lineages to better infiltrate and proliferate at a desired target, e.g., a tissue, or organ in need of cell replacement therapy. For providing cells and tissues for transplant to a non-human mammal, the cells and tissues can be isolated from a gastrulating embryo produced by same-species nuclear transfer. Histocompatible cells and tissues for transplant to a human can be isolated from a gastrulating embryo that (i) is genetically modified to be in capable of developing beyond and early stage, or (ii) is produced by cross-species nuclear transfer between a human nuclear donor cell and an enucleated recipient cell, e.g., an oocyte, of a non-human mammal, or (iii) is produced by androgenesis or gynogenesis, or from pluripotent stem cells generated from such an embryo. Methods for producing histocompatible cells and tissues for transplant to a human can also be used to produce such cells or tissues for transplant to non-human mammals. The present invention also provides model embryonic systems having defined genetic makeup that are useful for developing and testing methods for cell and tissue therapy, and for studying genetic imprinting, reprogramming, rejuvenation, and other biochemical, metabolic, and physiological phenomena associated with embryogenesis.

    Abstract translation: 使用与人或非人哺乳动物移植受体组织相容的细胞和组织提供改进的细胞治疗方法。 本发明生产的用于移植的细胞和组织表现出年轻状态，并且可以致力于特定的细胞谱系，以在期望的靶，例如需要细胞替代疗法的组织或器官中更好地渗透和增殖。 为了提供用于移植到非人哺乳动物的细胞和组织，细胞和组织可以从通过相同种类的核转移产生的诱导胚胎中分离出来。 用于移植到人的组织相容的细胞和组织可以从一个起胚胚胎中分离出来，其中（i）经遗传修饰以能够发展到超前和早期阶段，或者（ii）是通过人类核之间的跨物种核转移产生的 供体细胞和去核的受体细胞，例如非人哺乳动物的卵母细胞，或（iii）通过雄激素或雌激素产生，或由这种胚胎产生的多能干细胞产生。 用于生产用于移植到人中的组织相容性细胞和组织的方法也可以用于产生用于移植到非人哺乳动物的这种细胞或组织。 本发明还提供具有确定的遗传构成的模型胚胎系统，其可用于细胞和组织治疗的开发和测试方法，以及用于研究与胚胎发生相关的遗传印记，重编程，复壮和其他生物化学，代谢和生理现象。

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