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    Production of ungulates, preferably bovines that produce human immunoglobulins
    2.
    发明授权
    Production of ungulates, preferably bovines that produce human immunoglobulins 有权
    有益动物的生产，优选生产人免疫球蛋白的牛

    公开(公告)号：US07820878B2

    公开(公告)日：2010-10-26

    申请号：US12151181

    申请日：2008-05-05

    Applicant: Richard A. Goldsby ,  James M. Robl ,  Barbara A. Osborne ,  Yoshimi Kuroiwa

    Inventor： Richard A. Goldsby ,  James M. Robl ,  Barbara A. Osborne ,  Yoshimi Kuroiwa

    IPC: C12N15/00 ,  A01K67/027

    CPC classification number: A01K67/0271 ,  A01K67/0276 ,  A01K2207/15 ,  A01K2217/052 ,  A01K2217/075 ,  A01K2227/101 ,  A01K2267/01 ,  C12N9/1051 ,  C12N15/8509

    Abstract: The present invention relates to a method of producing an ungulate having both copies of the IgM heavy chain (mu) rag-1 and/or rag-2 gene eliminated from its genome. Animals which have IgM, rag-1 and/or rag-2 eliminated from their genome are unable to conduct the gene rearrangements that are necessary to generate the antigen receptors of B- or T-lymphocytes, and therefore will not develop native B- or T-cells. Because they are unable to produce B- and T-lymphocytes, these IgM, rag-1, or rag-2 ungulates cannot reject human hematopoietic stem cell preparations, and B- and T-lymphocytes which develop therefrom. Therefore, the present invention also involves injecting into IgM, rag-1, and/or rag-2 deficient ungulates, in utero or shortly after birth, human B- and T-lymphocytes whose immune systems produce human immunoglobulin that can be processed for therapeutic uses in humans.

    Abstract translation: 本发明涉及生产具有从其基因组中消除的IgM重链（mu）rag-1和/或rag-2基因的两个拷贝的有蹄类动物的方法。 从其基因组中消除IgM，rag-1和/或rag-2的动物不能进行产生B或T淋巴细胞的抗原受体所必需的基因重排，因此不会产生天然的B或 T细胞。 由于它们不能产生B细胞和T淋巴细胞，所以这些IgM，rag-1或rag-2有蹄类动物不能排斥人造血干细胞制备物和从其发育的B细胞和T淋巴细胞。 因此，本发明还涉及在子宫内或出生后不久的IgM，rag-1和/或rag-2缺陷型有蹄类动物中注射免疫系统产生可免疫治疗的人免疫球蛋白的人B淋巴细胞和T-淋巴细胞 用于人类。

    Production of ungulates, preferably bovines that produce human immunoglobulins
    5.
    发明申请
    Production of ungulates, preferably bovines that produce human immunoglobulins 有权
    有益动物的生产，优选生产人免疫球蛋白的牛

    公开(公告)号：US20090276866A1

    公开(公告)日：2009-11-05

    申请号：US12151181

    申请日：2008-05-05

    Applicant: Richard A. Goldsby ,  James M. Robl ,  Barbara A. Osborne ,  Yoshimi Kuroiwa

    Inventor： Richard A. Goldsby ,  James M. Robl ,  Barbara A. Osborne ,  Yoshimi Kuroiwa

    IPC: A01K67/027 ,  C12N15/89 ,  C12N15/87

    CPC classification number: A01K67/0271 ,  A01K67/0276 ,  A01K2207/15 ,  A01K2217/052 ,  A01K2217/075 ,  A01K2227/101 ,  A01K2267/01 ,  C12N9/1051 ,  C12N15/8509

    Abstract: The present invention relates to a method of producing an ungulate having both copies of the IgM heavy chain (mu) rag-1 and/or rag-2 gene eliminated from its genome. Animals which have IgM, rag-1 and/or rag-2 eliminated from their genome are unable to conduct the gene rearrangements that are necessary to generate the antigen receptors of B- or T-lymphocytes, and therefore will not develop native B- or T-cells. Because they are unable to produce B- and T-lymphocytes, these IgM, rag-1, or rag-2 ungulates cannot reject human hematopoietic stem cell preparations, and B- and T-lymphocytes which develop therefrom. Therefore, the present invention also involves injecting into IgM, rag-1, and/or rag-2 deficient ungulates, in utero or shortly after birth, human B- and T-lymphocytes whose immune systems produce human immunoglobulin that can be processed for therapeutic uses in humans.

    Abstract translation: 本发明涉及生产具有从其基因组中消除的IgM重链（mu）rag-1和/或rag-2基因的两个拷贝的有蹄类动物的方法。 具有从其基因组中消除的IgM，rag-1和/或rag-2的动物不能进行产生B或T淋巴细胞的抗原受体所必需的基因重排，因此不会产生天然的B或 T细胞。 由于它们不能产生B细胞和T淋巴细胞，所以这些IgM，rag-1或rag-2有蹄类动物不能排斥人造血干细胞制备物和从其发育的B细胞和T淋巴细胞。 因此，本发明还涉及在子宫内或出生后不久的IgM，rag-1和/或rag-2缺陷型有蹄类动物中注射免疫系统产生可免疫治疗的人免疫球蛋白的人B淋巴细胞和T-淋巴细胞 用于人类。

    USE OF HAPLOID GENOMES FOR GENETIC DIAGNOSIS, MODIFICATION AND MULTIPLICATION
    8.
    发明申请
    USE OF HAPLOID GENOMES FOR GENETIC DIAGNOSIS, MODIFICATION AND MULTIPLICATION 有权
    使用HAPLOID基因进行遗传诊断，修改和修复

    公开(公告)号：US20110287429A1

    公开(公告)日：2011-11-24

    申请号：US13015968

    申请日：2011-01-28

    Applicant: James M. Robl ,  Pedro Moreira

    Inventor： James M. Robl ,  Pedro Moreira

    IPC: C12Q1/68 ,  C12N5/071

    CPC classification number: C12N15/873 ,  C12N2510/00 ,  C12N2517/04

    Abstract: Methods for propagating haploid genomes of male or female origina and genetic screening and modification thereof are provided. These haploid genomes may be used to produce haploid embryos, and embryonic stem-like cells and differentiated cells. Also, these haploid genomes and cells containing, may be used as nuclear transfer donors to produce diploid nuclear transfer units. These diploid NT units e.g., human NT units, may be used to obtain pluripotent cells and differentiated cells and tissues.

    Abstract translation: 提供了用于繁殖男性或女性原发单倍体基因组的方法和遗传筛选及其修饰。 这些单倍体基因组可用于产生单倍体胚胎和胚胎干样细胞和分化细胞。 此外，这些单倍体基因组和细胞可以用作核转移供体以产生二倍体核转移单位。 这些二倍体NT单位例如人NT单位可用于获得多能细胞和分化的细胞和组织。

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