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1.发明授权Batch filtration system for preparation of sterile fluid for renal replacement therapy 有权用于制备用于肾替代治疗的无菌液体的分批过滤系统公开(公告)号：US08460558B2
公开(公告)日：2013-06-11
申请号：US13526145
申请日：2012-06-18
CPC分类号： A61M1/1656 , A61M1/14 , A61M1/166 , A61M1/167 , A61M1/1672 , A61M1/1674 , A61M1/28 , A61M1/288 , A61M1/3462 , A61M2205/12 , C02F1/44
摘要： A first connector of a connector assembly of a sterile batch container can be unsealed. The connector assembly can be attached to a filling port of the sterile batch container and can have a sterile filter arranged between the filling port and the first connector. The first connector can be coupled so as to receive produced purified water. A transmembrane pressure can be monitored across the sterile filter while flowing the purified water through the connector assembly into the sterile batch container so as to provide a sterile fluid stored therein. The connector assembly can be detached from the filling port of the sterile batch container. After the detaching, the sterile batch container can be coupled to the blood treatment system. In response to a change in the transmembrane pressure exceeding a predefined level, an alarm signal can be generated.
摘要翻译： 无菌批量容器的连接器组件的第一连接器可以是非密封的。 连接器组件可以附接到无菌批量容器的填充口，并且可以具有布置在填充口和第一连接器之间的无菌过滤器。 第一连接器可以联接以便接收产生的净化水。 可以跨越无菌过滤器监测跨膜压力，同时将净化水流过连接器组件进入无菌分批容器，以提供储存在其中的无菌流体。 连接器组件可以从无菌批量容器的填充口分离。 分离后，无菌批量容器可以与血液处理系统联接。 响应于超过预定水平的跨膜压力的变化，可以产生报警信号。
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2.发明授权Batch filtration system for preparation of sterile fluid for renal replacement therapy 有权用于制备用于肾替代治疗的无菌液体的分批过滤系统公开(公告)号：US08202420B2
公开(公告)日：2012-06-19
申请号：US13159045
申请日：2011-06-13
CPC分类号： A61M1/1656 , A61M1/14 , A61M1/166 , A61M1/167 , A61M1/1672 , A61M1/1674 , A61M1/28 , A61M1/288 , A61M1/3462 , A61M2205/12 , C02F1/44
摘要： A method and device for blood treatments that use fluids such as dialysate and replacement fluid for renal replacement therapy. In an embodiment, fluid is passed either by pump or passively by gravity feed, through a microporous sterilization filter from a fluid source to a replacement fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment. As a result, the sterilization filter can have a small capacity. In another embodiment, a filter is placed immediately prior to the point at which the sterile fluid is consumed by the treatment process. The latter may be used in combination with the former embodiment as a last-chance guarantee of sterility and/or that the fluid is free of air bubbles. It may also be used as the primary means of sterile-filtration.
摘要翻译： 用于血液处理的方法和装置，其使用诸如透析液和替代液的流体用于肾替代治疗。 在一个实施例中，流体通过泵或被动地通过重力进料通过微孔灭菌过滤器从流体源传递到替换流体容器。 后者形成可在治疗期间使用的批次。 在处理之前形成批次的优点是过滤速率与处理过程中的消耗速率不一致。 结果，灭菌过滤器可以具有小容量。 在另一个实施方案中，过滤器被立即放置在无菌流体被处理过程消耗的点之前。 后者可以与前一个实施方案组合使用，作为不育的最后机会保证和/或流体没有气泡。 它也可以用作无菌过滤的主要手段。
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3.发明申请Batch Filtration System for Preparation of Sterile Fluid for Renal Replacement Therapy 有权用于肾脏替代治疗的无菌液的制备过滤系统公开(公告)号：US20090211975A1
公开(公告)日：2009-08-27
申请号：US12434246
申请日：2009-05-01
CPC分类号： A61M1/1656 , A61M1/14 , A61M1/166 , A61M1/167 , A61M1/1672 , A61M1/1674 , A61M1/28 , A61M1/288 , A61M1/3462 , A61M2205/12 , C02F1/44
摘要： A method and device for blood treatments that use fluids such as dialysate and replacement fluid for renal replacement therapy. In an embodiment, fluid is passed either by pump or passively by gravity feed, through a microporous sterilization filter from a fluid source to a replacement fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment. As a result, the sterilization filter can have a small capacity. In another embodiment, a filter is placed immediately prior to the point at which the sterile fluid is consumed by the treatment process. The latter may be used in combination with the former embodiment as a last-chance guarantee of sterility and/or that the fluid is free of air bubbles. It may also be used as the primary means of sterile-filtration.
摘要翻译： 用于血液处理的方法和装置，其使用诸如透析液和替代液的流体用于肾替代治疗。 在一个实施例中，流体通过泵或被动地通过重力进料通过微孔灭菌过滤器从流体源传递到替换流体容器。 后者形成可在治疗期间使用的批次。 在处理之前形成批次的优点是过滤速率与处理过程中的消耗速率不一致。 结果，灭菌过滤器可以具有小容量。 在另一个实施方案中，过滤器被立即放置在无菌流体被处理过程消耗的点之前。 后者可以与前一个实施方案组合使用，作为不育的最后机会保证和/或流体没有气泡。 它也可以用作无菌过滤的主要手段。
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公开(公告)号：US20090182263A1
公开(公告)日：2009-07-16
申请号：US12296415
申请日：2007-04-09
申请人： Jeffrey H. Burbank , Dennis M. Treu , Goetz Freiderichs , Brian C. Green , Christopher M. McDowell , James M. Brugger
发明人： Jeffrey H. Burbank , Dennis M. Treu , Goetz Freiderichs , Brian C. Green , Christopher M. McDowell , James M. Brugger
CPC分类号： A61M1/1668 , A61J1/05 , A61J1/1468 , A61J1/1475 , A61J1/2003 , A61M1/14 , A61M1/1656 , A61M1/167 , A61M1/1672 , A61M1/1674 , A61M1/28 , A61M1/3413 , A61M1/342 , A61M1/3462 , A61M39/1011 , A61M39/288 , A61M2205/273 , B01D61/14 , B01D61/142 , B01D61/145 , B01D63/00 , B01L3/502 , B01L2200/026 , B01L2200/0605 , B01L2200/0689 , B01L2300/0681 , B01L2300/0864 , B65B3/28 , B65B3/30 , B65B55/04 , C02F1/444 , C02F2103/026 , F16K7/068 , F16L55/00 , F16L55/07 , Y10T137/8593
摘要： Systems, methods, and devices for preparation of purified water and medicaments for various uses including blood treatment are described. Methods, devices, and systems for creating multiple-treatment batches are described.
摘要翻译： 描述了用于制备用于包括血液处理在内的各种用途的纯化水和药物的系统，方法和装置。 描述了用于创建多个处理批次的方法，设备和系统。
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5.发明授权Batch filtration system for preparation of sterile fluid for renal replacement therapy 有权用于制备用于肾替代治疗的无菌液体的分批过滤系统公开(公告)号：US07544300B2
公开(公告)日：2009-06-09
申请号：US11160764
申请日：2005-07-07
CPC分类号： A61M1/1656 , A61M1/14 , A61M1/166 , A61M1/167 , A61M1/1672 , A61M1/1674 , A61M1/28 , A61M1/288 , A61M1/3462 , A61M2205/12 , C02F1/44
摘要： A method and device for blood treatments that use fluids such as dialysate and replacement fluid for renal replacement therapy. In an embodiment, fluid is passed either by pump or passively by gravity feed, through a microporous sterilization filter from a fluid source to a replacement fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment. As a result, the sterilization filter can have a small capacity. In another embodiment, a filter is placed immediately prior to the point at which the sterile fluid is consumed by the treatment process. The latter may be used in combination with the former embodiment as a last-chance guarantee of sterility and/or that the fluid is free of air bubbles. It may also be used as the primary means of sterile-filtration.
摘要翻译： 用于血液处理的方法和装置，其使用诸如透析液和替代液的流体用于肾替代治疗。 在一个实施例中，流体通过泵或被动地通过重力进料通过微孔灭菌过滤器从流体源传递到替换流体容器。 后者形成可在治疗期间使用的批次。 在处理之前形成批次的优点是过滤速率与处理过程中的消耗速率不一致。 结果，灭菌过滤器可以具有小容量。 在另一个实施方案中，过滤器被立即放置在无菌流体被处理过程消耗的点之前。 后者可以与前一个实施方案组合使用，作为不育的最后机会保证和/或流体没有气泡。 它也可以用作无菌过滤的主要手段。
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6.发明授权Batch filtration system for preparation of sterile fluid for renal replacement therapy 有权用于制备用于肾替代治疗的无菌液体的分批过滤系统公开(公告)号：US07976711B2
公开(公告)日：2011-07-12
申请号：US12786255
申请日：2010-05-24
CPC分类号： A61M1/1656 , A61M1/14 , A61M1/166 , A61M1/167 , A61M1/1672 , A61M1/1674 , A61M1/28 , A61M1/288 , A61M1/3462 , A61M2205/12 , C02F1/44
摘要： A method and device for blood treatments that use fluids such as dialysate and replacement fluid for renal replacement therapy. In an embodiment, fluid is passed either by pump or passively by gravity feed, through a microporous sterilization filter from a fluid source to a replacement fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment. As a result, the sterilization filter can have a small capacity. In another embodiment, a filter is placed immediately prior to the point at which the sterile fluid is consumed by the treatment process. The latter may be used in combination with the former embodiment as a last-chance guarantee of sterility and/or that the fluid is free of air bubbles. It may also be used as the primary means of sterile-filtration.
摘要翻译： 用于血液处理的方法和装置，其使用诸如透析液和替代液的流体用于肾替代治疗。 在一个实施例中，流体通过泵或被动地通过重力进料通过微孔灭菌过滤器从流体源传递到替换流体容器。 后者形成可在治疗期间使用的批次。 在处理之前形成批次的优点是过滤速率与处理过程中的消耗速率不一致。 结果，灭菌过滤器可以具有小容量。 在另一个实施方案中，过滤器被立即放置在无菌流体被处理过程消耗的点之前。 后者可以与前一个实施方案组合使用，作为不育的最后机会保证和/或流体没有气泡。 它也可以用作无菌过滤的主要手段。
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7.发明授权Batch filtration system for preparation of sterile fluid for renal replacement therapy 有权用于制备用于肾替代治疗的无菌液体的分批过滤系统公开(公告)号：US07749393B2
公开(公告)日：2010-07-06
申请号：US12434246
申请日：2009-05-01
CPC分类号： A61M1/1656 , A61M1/14 , A61M1/166 , A61M1/167 , A61M1/1672 , A61M1/1674 , A61M1/28 , A61M1/288 , A61M1/3462 , A61M2205/12 , C02F1/44
摘要： A method and device for blood treatments that use fluids such as dialysate and replacement fluid for renal replacement therapy. In an embodiment, fluid is passed either by pump or passively by gravity feed, through a microporous sterilization filter from a fluid source to a replacement fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment. As a result, the sterilization filter can have a small capacity. In another embodiment, a filter is placed immediately prior to the point at which the sterile fluid is consumed by the treatment process. The latter may be used in combination with the former embodiment as a last-chance guarantee of sterility and/or that the fluid is free of air bubbles. It may also be used as the primary means of sterile-filtration.
摘要翻译： 用于血液处理的方法和装置，其使用诸如透析液和替代液的流体用于肾替代治疗。 在一个实施例中，流体通过泵或被动地通过重力进料通过微孔灭菌过滤器从流体源传递到替换流体容器。 后者形成可在治疗期间使用的批次。 在处理之前形成批次的优点是过滤速率与处理过程中的消耗速率不一致。 结果，灭菌过滤器可以具有小容量。 在另一个实施方案中，过滤器被立即放置在无菌流体被处理过程消耗的点之前。 后者可以与前一个实施方案组合使用，作为不育的最后机会保证和/或流体没有气泡。 它也可以用作无菌过滤的主要手段。
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公开(公告)号：US20080230450A1
公开(公告)日：2008-09-25
申请号：US11813472
申请日：2006-01-09
申请人： Jeffrey H. Burbank , Dennis M. Treu , Gotz Friederichs , Brian C. Green , Christopher S. McDowell , James M. Brugger
发明人： Jeffrey H. Burbank , Dennis M. Treu , Gotz Friederichs , Brian C. Green , Christopher S. McDowell , James M. Brugger
IPC分类号： B01D35/143 , A61M1/16
CPC分类号： A61M1/1656 , A61M1/1668 , A61M1/167 , A61M1/28 , A61M1/288 , A61M2205/12
摘要： Systems, methods, and devices for preparation of water for various uses including blood treatment are described. In embodiments, fluid is passed either by pump or passively by gravity feed, through various filtration elements from a fluid source to a treatment fluid container The latter forms a batch that may be used during treatment. Methods and systems for creating multiple-treatment batches are described. Advantages of creating a multitreatment batch include the fact that the burden of treatment preparation can be reduced and the timing of the preparation of the batch can be independent of the treatment time. As described, there are various trade-offs and concerns with this approach which are addressed by the inventive embodiments.
摘要翻译： 描述了用于制备包括血液处理在内的各种用途的水的系统，方法和装置。 在实施例中，流体通过泵或被动地通过重力进料通过各种过滤元件从流体源传递到处理流体容器。后者形成可在处理期间使用的批次。 描述了用于创建多个处理批次的方法和系统。 创建多处理批次的优点包括可以减少处理制剂的负担并且批次的制备时间可以独立于处理时间的事实。 如上所述，本发明实施例解决了这种方法的各种权衡和关切。
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公开(公告)号：US20110240547A1
公开(公告)日：2011-10-06
申请号：US13159045
申请日：2011-06-13
IPC分类号： B01D63/00
CPC分类号： A61M1/1656 , A61M1/14 , A61M1/166 , A61M1/167 , A61M1/1672 , A61M1/1674 , A61M1/28 , A61M1/288 , A61M1/3462 , A61M2205/12 , C02F1/44
摘要： A method and device for blood treatments that use fluids such as dialysate and replacement fluid for renal replacement therapy. In an embodiment, fluid is passed either by pump or passively by gravity feed, through a microporous sterilization filter from a fluid source to a replacement fluid container. The latter forms a batch that may be used during treatment. The advantage of forming the batch before treatment is that the rate of filtering needn't match the rate of consumption during treatment. As a result, the sterilization filter can have a small capacity. In another embodiment, a filter is placed immediately prior to the point at which the sterile fluid is consumed by the treatment process. The latter may be used in combination with the former embodiment as a last-chance guarantee of sterility and/or that the fluid is free of air bubbles. It may also be used as the primary means of sterile-filtration.
摘要翻译： 用于血液处理的方法和装置，其使用诸如透析液和替代液的流体用于肾替代治疗。 在一个实施例中，流体通过泵或被动地通过重力进料通过微孔灭菌过滤器从流体源传递到替换流体容器。 后者形成可在治疗期间使用的批次。 在处理之前形成批次的优点是过滤速率与处理过程中的消耗速率不一致。 结果，灭菌过滤器可以具有小容量。 在另一个实施方案中，过滤器被立即放置在无菌流体被处理过程消耗的点之前。 后者可以与前一个实施方案组合使用，作为不育的最后机会保证和/或流体没有气泡。 它也可以用作无菌过滤的主要手段。
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公开(公告)号：US09700663B2
公开(公告)日：2017-07-11
申请号：US11813472
申请日：2006-01-09
申请人： Jeffrey H. Burbank , Dennis M. Treu , Götz Friederichs , Brian C. Green , Christopher S. McDowell , James M. Brugger
发明人： Jeffrey H. Burbank , Dennis M. Treu , Götz Friederichs , Brian C. Green , Christopher S. McDowell , James M. Brugger
CPC分类号： A61M1/1656 , A61M1/1668 , A61M1/167 , A61M1/28 , A61M1/288 , A61M2205/12
摘要： Systems, methods, and devices for preparation of water for various uses including blood treatment are described. In embodiments, fluid is passed either by pump or passively by gravity feed, through various filtration elements from a fluid source to a treatment fluid container. The latter forms a batch that may be used during treatment. Methods and systems for creating multiple-treatment batches are described. Advantages of creating a multitreatment batch include the fact that the burden of treatment preparation can be reduced and the timing of the preparation of the batch can be independent of the treatment time. As described, there are various trade-offs and concerns with this approach which are addressed by the inventive embodiments.
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