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1.发明申请Immunostimulating Polysaccharides Isolated From Curcuma Xanthorrhiza and Manufacturing Method Thereof 审中-公开免疫刺激从姜黄素分离的多糖及其制备方法公开(公告)号：US20100048885A1
公开(公告)日：2010-02-25
申请号：US11922107
申请日：2006-06-14
申请人： Jae-Kwan Hwang , Ah-Jin Kim , Jong-Hee Sohn , Kyu-Lee Han , Sun-Hee Lee , Jeong-Han Choo
发明人： Jae-Kwan Hwang , Ah-Jin Kim , Jong-Hee Sohn , Kyu-Lee Han , Sun-Hee Lee , Jeong-Han Choo
CPC分类号： C08B37/006 , C12P19/04
摘要： The present invention provides a method for manufacturing polysaccharides isolated from Curcuma xanthorrhiza, including steps of: (S1) preparing a powder of Curcuma xanthorrhiza Roxb.; (S2) extracting the powder with an organic solvent, and then filtering or centrifuging to obtain a residue; (S3) extracting the residue to prepare a solution containing polysaccharides; (S4) removing starch by adding starch-hydrolyzing enzyme to the polysaccharides-containing solution; (S5) precipitating the polysaccharides after the step (S4); and (S6) purifying the polysaccharides after the step (S5), polysaccharides obtained according to the manufacturing method, and a pharmaceutical composition in eluding the polysaccharides as effective component. The polysaccharides according to the present invention may be very effectively used in drugs and functional foods for stimulating macrophage activity, preventing and treating immunological diseases including cancer, and enhancing immunity after the treatment of the immunological diseases.
摘要翻译： 本发明提供了从姜黄分离得到的多糖的制造方法，包括以下步骤：（S1）制备姜黄黄酮粉末; （S2）用有机溶剂萃取粉末，然后过滤或离心得到残留物; （S3）提取残渣以制备含有多糖的溶液; （S4）通过向含多糖溶液中加入淀粉水解酶除去淀粉; （S5）在步骤（S4）后沉淀多糖; 和（S6）步骤（S5）后的多糖的纯化，根据制造方法得到的多糖，以及除了多糖作为有效成分的药物组合物。 本发明的多糖可以非常有效地用于药物和功能性食品中，用于刺激巨噬细胞活性，预防和治疗免疫疾病，包括癌症，以及增强免疫疾病治疗后的免疫力。
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2.发明申请公开(公告)号：US20110071221A1
公开(公告)日：2011-03-24
申请号：US11922509
申请日：2006-06-27
申请人： Jae-Kwan Hwang , Kyu-Lee Han , Jong-Hee Sohn , Ah-Jin Kim , Jeong-Han Choo , Jae-Young Lee , Jeong-Hwan Kim , Do Un Kim , Heechul Chung , Jae Youn Chung
发明人： Jae-Kwan Hwang , Kyu-Lee Han , Jong-Hee Sohn , Ah-Jin Kim , Jeong-Han Choo , Jae-Young Lee , Jeong-Hwan Kim , Do Un Kim , Heechul Chung , Jae Youn Chung
IPC分类号： A61K31/357 , A61P3/00
CPC分类号： A61K31/357
摘要： Disclosed is a method for treating PPAR (peroxisome proliferator activated receptor)mediated diseases, such as diabetes mellitus and diabetic complications, which includes administering to a subject an effective amount of macelignan represented by the following Formula (I): or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明公开了一种治疗PPAR（过氧化物酶体增殖物激活受体）介导的疾病如糖尿病和糖尿病并发症的方法，其包括向受试者施用有效量的由下式（I）表示的肉豆蔻衣木脂或其药学上可接受的盐 。
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公开(公告)号：US07902254B1
公开(公告)日：2011-03-08
申请号：US11922509
申请日：2006-06-27
申请人： Jae-Kwan Hwang , Kyu-Lee Han , Jong-Hee Sohn , Ah-Jin Kim , Jeong-Han Choo , Jae-Young Lee , Jeong-Hwan Kim , Do Un Kim , Heechul Chung , Jae Youn Chung
发明人： Jae-Kwan Hwang , Kyu-Lee Han , Jong-Hee Sohn , Ah-Jin Kim , Jeong-Han Choo , Jae-Young Lee , Jeong-Hwan Kim , Do Un Kim , Heechul Chung , Jae Youn Chung
IPC分类号： A61K31/36
CPC分类号： A61K31/357
摘要： Disclosed is a method for treating PPAR (peroxisome proliferator activated receptor)-mediated diseases, such as diabetes mellitus, which includes administering to a subject an effective amount of macelignan represented by the following Formula (I): or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明公开了一种治疗PPAR（过氧化物酶体增殖物激活受体）介导的疾病如糖尿病的方法，其包括向受试者施用有效量的由下式（I）表示的肉豆蔻衣木脂或其药学上可接受的盐。
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公开(公告)号：US20080275111A1
公开(公告)日：2008-11-06
申请号：US11909976
申请日：2006-03-31
申请人： Jae-Kwan Hwang , Jung-Soo Han , Chol-Seung Lim , Daqing Jin , Sun-Hee Lee , Kyu-Lee Han
发明人： Jae-Kwan Hwang , Jung-Soo Han , Chol-Seung Lim , Daqing Jin , Sun-Hee Lee , Kyu-Lee Han
CPC分类号： A61K36/185 , A61K31/357
摘要： The present invention relates to the novel use of lignan compounds represented by Formula I. More particularly, the present invention relates to a pharmaceutical composition for treating or preventing a brain disease, comprising a lignan compound represented by Formula I or a Myristica fragrans extract as an active ingredient, as well as the method and use for treating or preventing a brain disease using the lignan compound. The lignan compound represented by Formula I has the effects of antioxidation, brain cell protection and antiinflammation. Accordingly, said lignan compound will be highly useful for treating or preventing a brain disease.
摘要翻译： 本发明涉及由式I表示的木酚素化合物的新用途。更具体地，本发明涉及用于治疗或预防脑疾病的药物组合物，其包含由式I表示的木酚素化合物或肉豆蔻酸提取物作为 活性成分，以及用于使用木脂素化合物治疗或预防脑部疾病的方法和用途。 由式I表示的木酚素化合物具有抗氧化，脑细胞保护和抗炎的作用。 因此，所述木脂素化合物对于治疗或预防脑部疾病是非常有用的。
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公开(公告)号：US20100285154A1
公开(公告)日：2010-11-11
申请号：US12766255
申请日：2010-04-23
申请人： Jae-Kwan Hwang , Do-Un Kim , Jae-Youn Chung , Hee-Chul Chung , Kyu-Lee Han
发明人： Jae-Kwan Hwang , Do-Un Kim , Jae-Youn Chung , Hee-Chul Chung , Kyu-Lee Han
CPC分类号： A61K31/36 , A61K9/0095 , A61K9/2054 , A61K36/185 , Y02A50/401 , Y10S514/859 , Y10S514/886
摘要： The present invention relates to the use of lignan compounds for treating or preventing an inflammatory disease. More particularly, it relates to a method for preventing or treating an inflammatory disease, comprising administering to a subject in need thereof an effective amount of macelignan represented by Chemical Formula I or a pharmaceutically acceptable salt thereof. The lignan compound has the effect of inhibiting inflammatory reactions by inhibiting the production or expression of inflammation mediators NO, iNOS, PGE2, COX-2 and TNF-α and by treating or preventing inflammatory disease in vivo. Accordingly, the lignan compound or a Myristica fragrans extract will be highly useful for the treatment or prevention of an inflammatory disease.
摘要翻译： 本发明涉及木素素化合物用于治疗或预防炎性疾病的用途。 更具体地说，本发明涉及一种预防或治疗炎性疾病的方法，其包括向有需要的受试者施用有效量的由化学式I表示的肉豆蔻衣木脂或其药学上可接受的盐。 木酚素化合物具有通过抑制炎症介质NO，iNOS，PGE2，COX-2和TNF-α的产生或表达并通过在体内治疗或预防炎性疾病来抑制炎症反应的作用。 因此，木脂素化合物或肉豆蔻提取物对于治疗或预防炎性疾病是非常有用的。
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6.发明申请公开(公告)号：US20080114058A1
公开(公告)日：2008-05-15
申请号：US11813590
申请日：2006-01-06
申请人： Jae-Kwan Hwang , Do-Un Kim , Jae-Youn Chung , Hee-Chul Chung , Kyu-Lee Han
发明人： Jae-Kwan Hwang , Do-Un Kim , Jae-Youn Chung , Hee-Chul Chung , Kyu-Lee Han
IPC分类号： A61K31/05 , A61K31/335
CPC分类号： A61K31/357 , Y02A50/40 , Y02A50/401
摘要： The present invention relates to the use of lignan compounds for treating or preventing an inflammatory disease. More particularly, it relates to a pharmaceutical composition for the treatment or prevention of an inflammatory disease, comprising a lignan compound represented by Formula I, as well as a treating method and the use of an inflammatory disease using the lignan compound. The lignan compound has the effect of inhibiting inflammatory reactions by inhibiting the production or expression of inflammation mediators NO, iNOS, PGE2, COX-2 and TNF-α. Accordingly, the lignan compound or a Myristica fragrans extract will be highly useful for the treatment or prevention of an inflammatory disease.
摘要翻译： 本发明涉及木素素化合物用于治疗或预防炎性疾病的用途。 更具体地说，本发明涉及用于治疗或预防炎性疾病的药物组合物，其包含式I所示的木酚素化合物，以及使用所述木酚素化合物的治疗方法和使用炎性疾病。 木酚素化合物具有通过抑制炎症介质NO，iNOS，PGE 2，COX-2和TNF-α的产生或表达来抑制炎症反应的作用。 因此，木脂素化合物或肉豆蔻提取物对于治疗或预防炎性疾病是非常有用的。
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7.发明授权公开(公告)号：US08853264B2
公开(公告)日：2014-10-07
申请号：US12766255
申请日：2010-04-23
申请人： Jae-Kwan Hwang , Do-Un Kim , Jae-Youn Chung , Hee-Chul Chung , Kyu-Lee Han
发明人： Jae-Kwan Hwang , Do-Un Kim , Jae-Youn Chung , Hee-Chul Chung , Kyu-Lee Han
CPC分类号： A61K31/36 , A61K9/0095 , A61K9/2054 , A61K36/185 , Y02A50/401 , Y10S514/859 , Y10S514/886
摘要： The present invention relates to the use of lignan compounds for treating or preventing an inflammatory disease. More particularly, it relates to a method for preventing or treating an inflammatory disease, comprising administering to a subject in need thereof an effective amount of macelignan represented by Chemical Formula I or a pharmaceutically acceptable salt thereof. The lignan compound has the effect of inhibiting inflammatory reactions by inhibiting the production or expression of inflammation mediators NO, iNOS, PGE2, COX-2 and TNF-α and by treating or preventing inflammatory disease in vivo. Accordingly, the lignan compound or a Myristica fragrans extract will be highly useful for the treatment or prevention of an inflammatory disease.
摘要翻译： 本发明涉及木素素化合物用于治疗或预防炎性疾病的用途。 更具体地说，本发明涉及一种预防或治疗炎性疾病的方法，其包括向有需要的受试者施用有效量的由化学式I表示的肉豆蔻衣木脂或其药学上可接受的盐。 木酚素化合物具有通过抑制炎症介质NO，iNOS，PGE2，COX-2和TNF-α的产生或表达并通过在体内治疗或预防炎性疾病来抑制炎症反应的作用。 因此，木脂素化合物或肉豆蔻提取物对于治疗或预防炎性疾病是非常有用的。
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公开(公告)号：US08435957B2
公开(公告)日：2013-05-07
申请号：US12665206
申请日：2008-06-20
申请人： Jae-Kwan Hwang , Hae Ji Lee , Jae Young Lee , Jae-Seok Shim , Jeong Hwan Kim , Do Un Kim , Heechul Chung , Jae Youn Chung
发明人： Jae-Kwan Hwang , Hae Ji Lee , Jae Young Lee , Jae-Seok Shim , Jeong Hwan Kim , Do Un Kim , Heechul Chung , Jae Youn Chung
IPC分类号： A61K31/70
摘要： The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme-1 (MMP-I, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.
摘要翻译： 本发明涉及木糖素化合物的新用途，其从肉豆蔻或肉豆蔻的肠道中分离和纯化用于抗皱，更具体地，本发明涉及用于抗皱的提取物的抗皱纹的新用途 肉豆蔻或肉豆蔻，fragrin A，奥维菌素7，licarin E和肉豆蔻衣木脂的提取物。 本发明的提取物和木脂素化合物具有抑制胶原降解酶-1（MMP-1，基质金属蛋白酶-1）和新型胶原（1型前胶原）的形成的作用，从而具有抑制由 光老化 因此，本发明的提取物和木酚素化合物可用于预防或治疗由光老化引起的皱纹。
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公开(公告)号：US20090192217A1
公开(公告)日：2009-07-30
申请号：US10585553
申请日：2005-01-07
申请人： Jae-Kwan Hwang , Jae-Youn Chung , Hee-Chul Chung , Kyung-Min Park
发明人： Jae-Kwan Hwang , Jae-Youn Chung , Hee-Chul Chung , Kyung-Min Park
IPC分类号： A01N43/30 , C07D317/54 , A61P31/04
CPC分类号： A61K31/085 , A61K31/05 , A61K31/352
摘要： The present invention relates to a method and composition for treating acne using lignan compounds represented by Formula 1. More particularly, the invention relates to an antibacterial composition against acne-causing bacteria, containing lignan compounds represented by Formula 1, as well as a method for treating acne using the same. The lignan compounds represented by Formula 1 are excellent not only in the antibacterial activity of, inhibiting the growth of acne-causing bacteria, but also in thermal stability. Accordingly, the lignan compounds may be useful as antibacterial agents against the acne-causing bacteria, and acne treatment agents.
摘要翻译： 本发明涉及使用由式1表示的木酚素化合物治疗痤疮的方法和组合物。更具体地说，本发明涉及含有由式1表示的木酚素化合物的抗痤疮细菌的抗菌组合物，以及用于 使用相同的治疗痤疮。 由式1表示的木酚素化合物不仅具有抑制痤疮细菌生长的抗菌活性以及热稳定性的优异性。 因此，木脂素化合物可用作抗痤疮细菌和痤疮治疗剂的抗菌剂。
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公开(公告)号：US20120288579A1
公开(公告)日：2012-11-15
申请号：US12665206
申请日：2009-06-20
申请人： Jae-Kwan Hwang , Hae Ji Lee , Jae Young Lee , Jae-Seok Shim , Jeong Hwan Kim , Do Un Kim , Heechul Chung , Jae Youn Chung
发明人： Jae-Kwan Hwang , Hae Ji Lee , Jae Young Lee , Jae-Seok Shim , Jeong Hwan Kim , Do Un Kim , Heechul Chung , Jae Youn Chung
IPC分类号： A61K36/575 , A61K31/075 , A61P17/00 , C07D317/46 , C07C43/23 , A61K31/357 , C07D407/10
CPC分类号： A61Q19/08 , A61K8/347 , A61K8/498 , A61K8/9789
摘要： The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme-1 (MMP-1, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.
摘要翻译： 本发明涉及木糖素化合物的新用途，其从肉豆蔻或肉豆蔻的肠道中分离和纯化用于抗皱，更具体地，本发明涉及用于抗皱的提取物的抗皱纹的新用途 肉豆蔻或肉豆蔻，fragrin A，奥维菌素7，licarin E和肉豆蔻衣木脂的提取物。 本发明的提取物和木脂素化合物具有抑制胶原降解酶-1（MMP-1，基质金属蛋白酶-1）和新型胶原（1型前胶原）的形成的作用，从而具有抑制由 光老化 因此，本发明的提取物和木酚素化合物可用于预防或治疗由光老化引起的皱纹。
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