公开(公告)号：US20180275127A1

公开(公告)日：2018-09-27

申请号：US15908568

申请日：2018-02-28

Applicant: JW BIOSCIENCE

Inventor： Sunghoon KIM ,  Mi Rim JIN ,  Young Ha AHN

IPC: G01N33/573 ,  C07K16/40 ,  C12Q1/6813 ,  C12Q1/689 ,  C12Q1/70

CPC classification number: G01N33/573 ,  C07K16/40 ,  C12Q1/68 ,  C12Q1/6813 ,  C12Q1/6883 ,  C12Q1/689 ,  C12Q1/701 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Y601/01002 ,  G01N2333/9015 ,  G01N2800/26 ,  G01N2800/56 ,  Y02A50/59

Abstract: The present invention relates to a composition for diagnosing infectious diseases by using a tryptophanyl-tRNA synthase (WRS) and a method for detecting a diagnostic marker and, more specifically, to: a composition for diagnosing infectious diseases, containing a preparation measuring the WRS protein or mRNA expression level; a diagnostic kit; a method for detecting the WRS for providing information required for the diagnosis of infectious diseases, and a method for determining the infectious disease mortality risk by using the WRS. According to the present invention, the WRS is increased only in infection-induced infectious diseases, differentiating non-infectious diseases therefrom, and is rapidly increased in the early stage of infection. In addition, the level of the WRS is closely correlated with the severity and prognosis of diseases or complications induced by infection. Therefore, the WRS can be used as a marker for more rapid and accurate diagnosis, in comparison to a conventional marker for infectious diseases or complications thereof.