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    Method and system for logging quantitative seizure information and assessing efficacy of therapy using cardiac signals
    1.
    发明授权
    Method and system for logging quantitative seizure information and assessing efficacy of therapy using cardiac signals 有权
    记录定量癫痫发作信息的方法和系统，并使用心脏信号评估治疗效果

    公开(公告)号：US09050469B1

    公开(公告)日：2015-06-09

    申请号：US10997540

    申请日：2004-11-24

    Applicant: Ivan Osorio ,  Mark G. Frei

    Inventor： Ivan Osorio ,  Mark G. Frei

    IPC: A61B5/04 ,  A61N1/36

    CPC classification number: A61N1/36064 ,  A61B5/04012 ,  A61B5/0452 ,  A61B5/0456 ,  A61B5/4094 ,  A61B5/4836 ,  A61B5/7282 ,  G06F19/3481 ,  G16H50/20

    Abstract: A system and method for analyzing and logging changes in brain state of a subject for administering therapy to the subject based on the at least one cardiac signal wherein the system and method comprises the steps of receiving at least one cardiac signal of the subject into a processor, analyzing the cardiac signal to detect at least one cardiac signal change indicative of a brain state change, and logging at least one characteristic of the detected signal change or the brain state change.

    Abstract translation: 一种用于基于所述至少一个心脏信号来分析和记录受试者脑部状态变化以对受试者进行治疗的系统和方法，其中所述系统和方法包括以下步骤：将所述受试者的至少一个心脏信号接收到处理器 分析心脏信号以检测指示脑状态改变的至少一个心脏信号变化，以及记录检测到的信号改变或脑状态改变的至少一个特征。

    Method and system for the prediction, rapid detection, warning, prevention, or control of changes in the brain states of a subject using hurst parameter estimation
    3.
    发明授权
    Method and system for the prediction, rapid detection, warning, prevention, or control of changes in the brain states of a subject using hurst parameter estimation 有权
    使用赫斯特参数估计预测，快速检测，警告，预防或控制受试者脑状态变化的方法和系统

    公开(公告)号：US08024032B1

    公开(公告)日：2011-09-20

    申请号：US11604407

    申请日：2006-11-27

    Applicant: Ivan Osorio ,  Mark G. Frei

    Inventor： Ivan Osorio ,  Mark G. Frei

    IPC: A61B5/04

    CPC classification number: A61B5/0476 ,  A61B5/16 ,  A61B5/165 ,  A61B5/4094 ,  A61B5/6814

    Abstract: A system for analyzing signals representative of a subject's brain activity in a signal processor for information indicating the subject's current activity state and for detecting or predicting a change in the activity state. One preferred embodiment uses a method for estimating the Hurst parameter to perform real-time analysis of the electroencephalogram (EEG) or electrocorticogram (ECoG) signals from a subject patient for information indicative of or predictive of a seizure, and to complete the needed analysis at least before clinical seizure onset. The preferred system then performs an output task for prevention or abatement of the seizure, or for recording pertinent data.

    Abstract translation: 一种用于分析表示受试者在脑部活动信号的信号的系统，用于指示受试者的当前活动状态的信息，以及用于检测或预测活动状态的变化。 一个优选实施例使用用于估计Hurst参数的方法来执行来自对象患者的脑电图（EEG）或电皮质图（ECoG）信号的实时分析，用于指示或预测癫痫发作的信息，并且完成所需的分析 至少在临床发作发作前。 优选的系统然后执行输出任务以防止或减少缉获量，或用于记录相关数据。

    Method, computer program, and system for intrinsic timescale decomposition, filtering, and automated analysis of signals of arbitrary origin or timescale
    4.
    发明授权
    Method, computer program, and system for intrinsic timescale decomposition, filtering, and automated analysis of signals of arbitrary origin or timescale 有权
    方法，计算机程序和系统，用于任意原点或时间尺度信号的固有时间尺度分解，滤波和自动分析

    公开(公告)号：US07966156B1

    公开(公告)日：2011-06-21

    申请号：US12217893

    申请日：2008-07-09

    Applicant: Mark G. Frei ,  Ivan Osorio

    Inventor： Mark G. Frei ,  Ivan Osorio

    IPC: G06F17/00 ,  G06F19/00

    CPC classification number: G06K9/00503 ,  G06F17/14 ,  G06K9/00523

    Abstract: A method and system for intrinsic timescale decomposition, filtering, and automated analysis of signals of arbitrary origin or timescale including receiving an input signal, determining a baseline segment and a monotonic residual segment with strictly negative minimum and strictly positive maximum between two successive extrema of the input signal, and producing a baseline output signal and a residual output signal. The method and system also includes determining at least one instantaneous frequency estimate from a proper rotation signal, determining a zero-crossing and a local extremum of the proper rotation signal, and applying interpolation thereto to determine an instantaneous frequency estimate thereof. The method and system further includes determining at least one instantaneous frequency estimate from a proper rotation signal, extracting an amplitude-normalized half wave therefrom and applying an arcsine function to the amplitude-normalized half wave to determine an instantaneous frequency estimate of the proper rotation signal.

    Abstract translation: 用于固有时间尺度分解，过滤和任意来源或时间尺度信号的自动分析的方法和系统，包括接收输入信号，确定基线段和具有严格为负的最小值和严格正的最大值的两个连续极值之间的单调残差段 输入信号，并产生基线输出信号和残留输出信号。 所述方法和系统还包括从适当的旋转信号确定至少一个瞬时频率估计，确定适当旋转信号的过零点和局部极值，以及对其进行插值以确定其瞬时频率估计。 所述方法和系统还包括从适当的旋转信号确定至少一个瞬时频率估计，从其中提取幅度归一化的半波，并对所述幅度归一化的半波应用反正弦函数，以确定适当旋转信号的瞬时频率估计 。

    Signal quality monitoring and control for a medical device system
    5.
    发明授权
    Signal quality monitoring and control for a medical device system 有权
    医疗器械系统的信号质量监测和控制

    公开(公告)号：US07917206B2

    公开(公告)日：2011-03-29

    申请号：US11557433

    申请日：2006-11-07

    Applicant: Mark G. Frei ,  Ivan Osorio

    Inventor： Mark G. Frei ,  Ivan Osorio

    IPC: A61N1/00

    CPC classification number: A61B5/04012 ,  A61B5/048 ,  A61B5/4094 ,  A61B5/7203 ,  A61B5/7217 ,  A61B5/7221 ,  A61N1/36014 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/36135 ,  A61N1/3702 ,  A61N1/37229 ,  A61N1/37252

    Abstract: Method and apparatus for detecting possible interference in a neurological signal received from a monitoring element of a medical device system. The monitoring element monitors a condition or a symptom of a nervous system disorder being treated and provides a neurological signal to the medical device system for purposes of providing closed-loop feedback control. The system analyzes various parameters of the received signal by taking instantaneous measurements of data points in moving window and thereby determining whether the signal is of poor quality. If the signal is of determined poor quality, it is removed from consideration in the closed-loop feedback control system until it is determined that the signal quality has sufficiently been restored.

    Abstract translation: 用于检测从医疗装置系统的监视元件接收的神经信号中的可能的干扰的方法和装置。 监测元件监测被治疗的神经系统疾病的状况或症状，并且为了提供闭环反馈控制的目的而向医疗装置系统提供神经信号。 该系统通过对移动窗口中的数据点进行瞬时测量，从而确定信号质量差，分析接收信号的各种参数。 如果信号确定质量差，则在闭环反馈控制系统中将其去除，直到确定信号质量已被充分恢复为止。

    Implantable interface for a medical device system
    6.
    发明授权
    Implantable interface for a medical device system 有权
    用于医疗设备系统的可植入界面

    公开(公告)号：US07856272B2

    公开(公告)日：2010-12-21

    申请号：US11414736

    申请日：2006-04-28

    Applicant: Alexei V. Nikitin ,  Ivan Osorio ,  Mark G. Frei ,  Naresh C. Bhavaraju

    Inventor： Alexei V. Nikitin ,  Ivan Osorio ,  Mark G. Frei ,  Naresh C. Bhavaraju

    IPC: A61N1/375

    CPC classification number: A61N1/0529 ,  A61M5/14276 ,  A61M5/16827 ,  A61M5/16881 ,  A61M2205/054 ,  A61M2205/3507 ,  A61M2210/0693 ,  A61N1/36082

    Abstract: An implantable interface system for a medical device system providing selective interconnectivity between conduits and therapy elements. The interface system contains connecting elements that each provide a robust connection between a selected conduit and a selected therapy element. The interface system enables the use of a surplus of therapy elements so that treatment to the same site (in the case of electrode migration or failure), or to different sites but within the spatial domain of the interface's elements may be delivered through the spare/excess therapy elements without the need for additional major surgical procedures.

    Abstract translation: 一种用于医疗装置系统的可植入界面系统，其提供导管和治疗元件之间的选择性互连。 接口系统包含连接元件，每个连接元件在所选导管和选定的治疗元件之间提供牢固的连接。 接口系统使得能够使用多余的治疗元件，使得可以通过备用/非接触式的治疗单元向相同部位（在电极迁移或失效的情况下）或不同部位但在界面元件的空间域内进行治疗， 多余的治疗元素，而不需要额外的主要外科手术。

    Vagal nerve stimulation techniques for treatment of epileptic seizures
    8.
    发明授权
    Vagal nerve stimulation techniques for treatment of epileptic seizures 有权
    迷走神经刺激技术治疗癫痫发作

    公开(公告)号：US06920357B2

    公开(公告)日：2005-07-19

    申请号：US10435832

    申请日：2003-05-12

    Applicant: Ivan Osorio ,  Mark G. Frei

    Inventor： Ivan Osorio ,  Mark G. Frei

    IPC: A61N1/36 ,  A61N1/18

    CPC classification number: A61B5/4094 ,  A61B5/02405 ,  A61B5/02455 ,  A61B5/0452 ,  A61B5/0456 ,  A61B5/686 ,  A61B5/7282 ,  A61B2560/0475 ,  A61N1/36053 ,  A61N1/36064 ,  A61N1/36114 ,  A61N1/36135

    Abstract: The present invention uses electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus nerve, and a sensor for sensing characteristics of the heart such as heart rate. The heart rate information from the sensor can be used to determine whether the vagus nerve stimulation is adversely affecting the heart. Once threshold parameters are met, the vagus nerve stimulation may be stopped or adjusted. In an alternative embodiment, the invention may include a modified pacemaker to maintain the heart in desired conditions during the vagus nerve stimulation. In yet another embodiment, the invention may be simply a modified pacemaker having circuitry that determines whether a vagus nerve is being stimulated. In the event that the vagus nerve is being stimulated, the modified pacemaker may control the heart to maintain it within desired conditions during the vagus nerve stimulation.

    Abstract translation: 本发明使用迷走神经的电刺激来治疗癫痫，对心脏具有最小化或不起作用。 治疗由可植入信号发生器，用于电刺激迷走神经的预定刺激部位的一个或多个可植入电极以及用于感测心脏特征的传感器例如心率进行。 来自传感器的心率信息可用于确定迷走神经刺激是否对心脏有不利影响。 一旦达到阈值参数，就可以停止或调整迷走神经刺激。 在替代实施例中，本发明可以包括修改的起搏器，以在迷走神经刺激期间将心脏保持在期望的状态。 在另一个实施例中，本发明可以简单地是具有确定是否正在刺激迷走神经的电路的改进的起搏器。 在迷走神经被刺激的情况下，修改的起搏器可以控制心脏在迷走神经刺激期间将其保持在期望的条件下。

    Method, computer program, and system for automated real-time signal analysis for detection, quantification, and prediction of signal changes
    9.
    发明授权
    Method, computer program, and system for automated real-time signal analysis for detection, quantification, and prediction of signal changes 有权
    方法，计算机程序和用于信号变化的检测，量化和预测的自动化实时信号分析系统

    公开(公告)号：US06768969B1

    公开(公告)日：2004-07-27

    申请号：US09824946

    申请日：2001-04-03

    Applicant: Alexei V. Nikitin ,  Mark G. Frei ,  Naresh C. Bhavaraju ,  Ivan Osorio

    Inventor： Alexei V. Nikitin ,  Mark G. Frei ,  Naresh C. Bhavaraju ,  Ivan Osorio

    IPC: G01L2100

    CPC classification number: G06K9/00536 ,  G06F17/10 ,  G06F17/18 ,  G06F19/24 ,  G16H50/20 ,  G16H50/50

    Abstract: A method, computer program, and system for real-time signal analysis providing characterization of temporally-evolving densities and distributions of signal features of arbitrary-type signals in a moving time window by tracking output of order statistic filters (also known as percentile, quantile, or rank-order filters). Given a raw input signal of arbitrary type, origin, or scale, the present invention enables automated quantification and detection of changes in the distribution of any set of quantifiable features of that signal as they occur in time. Furthermore, the present invention's ability to rapidly and accurately detect changes in certain features of an input signal can also enable prediction in cases where the detected changes associated with an increased likelihood of future signal changes.

    Abstract translation: 一种用于实时信号分析的方法，计算机程序和系统，通过跟踪顺序统计滤波器的输出（也称为百分位数，分位数）来提供移动时间窗口中的任意类型信号的时间演化密度和信号特征分布的表征 或等级阶滤波器）。 给定任意类型，原点或尺度的原始输入信号，本发明能够自动量化和检测该信号随时间发生的任何一组可量化特征的分布变化。 此外，本发明快速准确地检测输入信号的某些特征的变化的能力还可以在与未来信号的可能性增加相关联的检测到的变化的情况下进行预测。

    Dynamic cranial nerve stimulation based on brain state determination from cardiac data
    10.
    发明授权
    Dynamic cranial nerve stimulation based on brain state determination from cardiac data 有权
    基于心脏数据的脑状态测定的动态颅神经刺激

    公开(公告)号：US08417344B2

    公开(公告)日：2013-04-09

    申请号：US12258019

    申请日：2008-10-24

    Applicant: John C. Colborn ,  Mark G. Frei ,  Ivan Osorio

    Inventor： John C. Colborn ,  Mark G. Frei ,  Ivan Osorio

    IPC: A61N1/00

    CPC classification number: A61B5/0205 ,  A61B5/04012 ,  A61N1/36082 ,  A61N1/36114

    Abstract: A method of treating a medical condition in a patient using an implantable medical device, comprising providing an electrical signal generator; providing at least a first electrode operatively coupled to the electrical signal generator and to a vagus nerve of the patient; sensing cardiac data of the patient; determining at least a first cardiac parameter based upon said cardiac data; setting at least a first value; declaring an unstable brain state of a patient from said at least a first cardiac parameter and said at least a first value; and adjusting the at least a first value. Also, a computer readable program storage device encoded with instructions that, when executed by a computer, performs the method. In addition, the implantable medical device used in the method.

    Abstract translation: 一种使用可植入医疗装置治疗患者的医疗状况的方法，包括提供电信号发生器; 提供至少可操作地耦合到所述电信号发生器和所述患者的迷走神经的第一电极; 感测患者的心脏数据; 基于所述心脏数据确定至少第一心脏参数; 设置至少第一个值; 从所述至少第一心脏参数和所述至少第一值宣告患者的不稳定脑状态; 以及调整所述至少第一值。 另外，一种计算机可读程序存储装置，其编码有由计算机执行时执行该方法的指令。 此外，该方法中使用的可植入医疗装置。

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