公开(公告)号：US20220162707A1

公开(公告)日：2022-05-26

申请号：US17494669

申请日：2021-10-05

Applicant: Inivata Ltd.

Inventor： Samuel Woodhouse ,  Stefanie Lensing ,  Tim Forshew ,  Vincent Plagnol ,  Matthew Edward Smith ,  Karen Howarth ,  Michael Epstein

IPC: C12Q1/6886 ,  C12Q1/6853 ,  C12Q1/6806 ,  C12Q1/686

Abstract: The present disclosure relates to methods for detecting and targeting genomic rearrangements, in particular gene fusion events, by targeting a DNA molecule of interest with a set or pool of primers, wherein the forward primers and reverse primers produce a PCR amplification product when a genomic rearrangement is present. The present disclosure also relates to methods of bioinformatic analysis to determine whether or not the detection of an amplification product from the selective PCR is actually indicative of the presence of a gene fusion. The present disclosure also related to related methods of diagnosis and treatment of diseases and conditions associated with such genomic rearrangements, in particular cancers, such as lung cancer.

公开(公告)号：US20200010905A1

公开(公告)日：2020-01-09

申请号：US16491141

申请日：2018-06-18

Applicant: Inivata Ltd.

Inventor： Samuel Woodhouse ,  Stefanie Lensing ,  Tim Forshew ,  Vincent Plagnol ,  Matthew Edward Smith ,  Karen Howarth ,  Michael Epstein

IPC: C12Q1/6886

Abstract: The present disclosure relates to methods for detecting and targeting genomic rearrangements, in particular gene fusion events, by targeting a DNA molecule of interest with a set or pool of primers, wherein the forward primers and reverse primers produce a PCR amplification product when a genomic rearrangement is present. The present disclosure also relates to methods of bioinformatic analysis to determine whether or not the detection of an amplification product from the selective PCR is actually indicative of the presence of a gene fusion. The present disclosure also related to related methods of diagnosis and treatment of diseases and conditions associated with such genomic rearrangements, in particular cancers, such as lung cancer.

公开(公告)号：US12084724B2

公开(公告)日：2024-09-10

申请号：US17494669

申请日：2021-10-05

Applicant: Inivata Ltd.

Inventor： Samuel Woodhouse ,  Stefanie Lensing ,  Tim Forshew ,  Vincent Plagnol ,  Matthew Edward Smith ,  Karen Howarth ,  Michael Epstein

IPC: C12Q1/6886 ,  C12Q1/6806 ,  C12Q1/6853 ,  C12Q1/686 ,  G16B20/00 ,  G16B30/00

CPC classification number: C12Q1/6886 ,  C12Q1/6806 ,  C12Q1/6853 ,  C12Q1/686 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/16 ,  G16B20/00 ,  G16B30/00 ,  C12Q1/6853 ,  C12Q2525/155 ,  C12Q2525/161 ,  C12Q2531/113 ,  C12Q2535/122 ,  C12Q2537/159

Abstract: The present disclosure relates to methods for detecting and targeting genomic rearrangements, in particular gene fusion events, by targeting a DNA molecule of interest with a set or pool of primers, wherein the forward primers and reverse primers produce a PCR amplification product when a genomic rearrangement is present. The present disclosure also relates to methods of bioinformatic analysis to determine whether or not the detection of an amplification product from the selective PCR is actually indicative of the presence of a gene fusion. The present disclosure also related to related methods of diagnosis and treatment of diseases and conditions associated with such genomic rearrangements, in particular cancers, such as lung cancer.

公开(公告)号：US20210139996A1

公开(公告)日：2021-05-13

申请号：US17100219

申请日：2020-11-20

Applicant: Inivata Ltd.

Inventor： Samuel Woodhouse ,  Stefanie Lensing ,  Tim Forshew ,  Vincent Plagnol ,  Matthew Edward Smith ,  Karen Howarth ,  Michael Epstein

IPC: C12Q1/6886 ,  C12Q1/6853 ,  C12Q1/6806 ,  C12Q1/686

Abstract: The present disclosure relates to methods for detecting and targeting genomic rearrangements, in particular gene fusion events, by targeting a DNA molecule of interest with a set or pool of primers, wherein the forward primers and reverse primers produce a PCR amplification product when a genomic rearrangement is present. The present disclosure also relates to methods of bioinformatic analysis to determine whether or not the detection of an amplification product from the selective PCR is actually indicative of the presence of a gene fusion. The present disclosure also related to related methods of diagnosis and treatment of diseases and conditions associated with such genomic rearrangements, in particular cancers, such as lung cancer.

公开(公告)号：US20190241977A1

公开(公告)日：2019-08-08

申请号：US16389588

申请日：2019-04-19

Applicant: Inivata Ltd.

Inventor： Samuel Woodhouse ,  Stefanie Lensing ,  Tim Forshew ,  Vincent Plagnol ,  Matthew Edward Smith ,  Karen Howarth ,  Michael Epstein

IPC: C12Q1/6886 ,  C12Q1/6853

CPC classification number: C12Q1/6886 ,  C12Q1/6806 ,  C12Q1/6853 ,  C12Q1/686 ,  C12Q2600/106 ,  C12Q2600/16 ,  G16B20/00 ,  G16B30/00 ,  C12Q2525/155 ,  C12Q2525/161 ,  C12Q2531/113 ,  C12Q2535/122 ,  C12Q2537/159

Abstract: The present disclosure relates to methods for detecting and targeting genomic rearrangements, in particular gene fusion events, by targeting a DNA molecule of interest with a set or pool of primers, wherein the forward primers and reverse primers produce a PCR amplification product when a genomic rearrangement is present. The present disclosure also relates to methods of bioinformatic analysis to determine whether or not the detection of an amplification product from the selective PCR is actually indicative of the presence of a gene fusion. The present disclosure also related to related methods of diagnosis and treatment of diseases and conditions associated with such genomic rearrangements, in particular cancers, such as lung cancer.

公开(公告)号：US20190241976A1

公开(公告)日：2019-08-08

申请号：US16389584

申请日：2019-04-19

Applicant: Inivata Ltd.

Inventor： Samuel Woodhouse ,  Stefanie Lensing ,  Tim Forshew ,  Vincent Plagnol ,  Matthew Edward Smith ,  Karen Howarth ,  Michael Epstein

IPC: C12Q1/6886 ,  C12Q1/6853

CPC classification number: C12Q1/6886 ,  C12Q1/6806 ,  C12Q1/6853 ,  C12Q1/686 ,  C12Q2600/106 ,  C12Q2600/16 ,  G16B20/00 ,  G16B30/00 ,  C12Q2525/155 ,  C12Q2525/161 ,  C12Q2531/113 ,  C12Q2535/122 ,  C12Q2537/159

Abstract: The present disclosure relates to methods for detecting and targeting genomic rearrangements, in particular gene fusion events, by targeting a DNA molecule of interest with a set or pool of primers, wherein the forward primers and reverse primers produce a PCR amplification product when a genomic rearrangement is present. The present disclosure also relates to methods of bioinformatic analysis to determine whether or not the detection of an amplification product from the selective PCR is actually indicative of the presence of a gene fusion. The present disclosure also related to related methods of diagnosis and treatment of diseases and conditions associated with such genomic rearrangements, in particular cancers, such as lung cancer.

公开(公告)号：US20190241975A1

公开(公告)日：2019-08-08

申请号：US16389573

申请日：2019-04-19

Applicant: Inivata Ltd.

Inventor： Samuel Woodhouse ,  Stefanie Lensing ,  Tim Forshew ,  Vincent Plagnol ,  Matthew Edward Smith ,  Karen Howarth ,  Michael Epstein

IPC: C12Q1/6886 ,  C12Q1/6853

CPC classification number: C12Q1/6886 ,  C12Q1/6806 ,  C12Q1/6853 ,  C12Q1/686 ,  C12Q2600/106 ,  C12Q2600/16 ,  G16B20/00 ,  G16B30/00 ,  C12Q2525/155 ,  C12Q2525/161 ,  C12Q2531/113 ,  C12Q2535/122 ,  C12Q2537/159

Abstract: The present disclosure relates to methods for detecting and targeting genomic rearrangements, in particular gene fusion events, by targeting a DNA molecule of interest with a set or pool of primers, wherein the forward primers and reverse primers produce a PCR amplification product when a genomic rearrangement is present. The present disclosure also relates to methods of bioinformatic analysis to determine whether or not the detection of an amplification product from the selective PCR is actually indicative of the presence of a gene fusion. The present disclosure also related to related methods of diagnosis and treatment of diseases and conditions associated with such genomic rearrangements, in particular cancers, such as lung cancer.

公开(公告)号：US20190241974A1

公开(公告)日：2019-08-08

申请号：US16389565

申请日：2019-04-19

Applicant: Inivata Ltd.

Inventor： Samuel Woodhouse ,  Stefanie Lensing ,  Tim Forshew ,  Vincent Plagnol ,  Matthew Edward Smith ,  Karen Howarth ,  Michael Epstein

IPC: C12Q1/6886 ,  C12Q1/6806 ,  C12Q1/686

CPC classification number: C12Q1/6886 ,  C12Q1/6806 ,  C12Q1/6853 ,  C12Q1/686 ,  C12Q2600/106 ,  C12Q2600/16 ,  G16B20/00 ,  G16B30/00 ,  C12Q2525/155 ,  C12Q2525/161 ,  C12Q2531/113 ,  C12Q2535/122 ,  C12Q2537/159

Abstract: The present disclosure relates to methods for detecting and targeting genomic rearrangements, in particular gene fusion events, by targeting a DNA molecule of interest with a set or pool of primers, wherein the forward primers and reverse primers produce a PCR amplification product when a genomic rearrangement is present. The present disclosure also relates to methods of bioinformatic analysis to determine whether or not the detection of an amplification product from the selective PCR is actually indicative of the presence of a gene fusion. The present disclosure also related to related methods of diagnosis and treatment of diseases and conditions associated with such genomic rearrangements, in particular cancers, such as lung cancer.

公开(公告)号：US11168371B2

公开(公告)日：2021-11-09

申请号：US16389596

申请日：2019-04-19

Applicant: Inivata Ltd.

Inventor： Samuel Woodhouse ,  Stefanie Lensing ,  Tim Forshew ,  Vincent Plagnol ,  Matthew Edward Smith ,  Karen Howarth ,  Michael Epstein

IPC: C12Q1/6853 ,  C12Q1/686 ,  G16B30/00 ,  C12Q1/6886 ,  C12Q1/6806 ,  G16B20/00

Abstract: The present disclosure relates to methods for detecting and targeting genomic rearrangements, in particular gene fusion events, by targeting a DNA molecule of interest with a set or pool of primers, wherein the forward primers and reverse primers produce a PCR amplification product when a genomic rearrangement is present. The present disclosure also relates to methods of bioinformatic analysis to determine whether or not the detection of an amplification product from the selective PCR is actually indicative of the presence of a gene fusion. The present disclosure also related to related methods of diagnosis and treatment of diseases and conditions associated with such genomic rearrangements, in particular cancers, such as lung cancer.

公开(公告)号：US20190241978A1

公开(公告)日：2019-08-08

申请号：US16389596

申请日：2019-04-19

Applicant: Inivata Ltd.

Inventor： Samuel Woodhouse ,  Stefanie Lensing ,  Tim Forshew ,  Vincent Plagnol ,  Matthew Edward Smith ,  Karen Howarth ,  Michael Epstein

IPC: C12Q1/6886 ,  C12Q1/6853

CPC classification number: C12Q1/6886 ,  C12Q1/6806 ,  C12Q1/6853 ,  C12Q1/686 ,  C12Q2600/106 ,  C12Q2600/16 ,  G16B20/00 ,  G16B30/00 ,  C12Q2525/155 ,  C12Q2525/161 ,  C12Q2531/113 ,  C12Q2535/122 ,  C12Q2537/159

Abstract: The present disclosure relates to methods for detecting and targeting genomic rearrangements, in particular gene fusion events, by targeting a DNA molecule of interest with a set or pool of primers, wherein the forward primers and reverse primers produce a PCR amplification product when a genomic rearrangement is present. The present disclosure also relates to methods of bioinformatic analysis to determine whether or not the detection of an amplification product from the selective PCR is actually indicative of the presence of a gene fusion. The present disclosure also related to related methods of diagnosis and treatment of diseases and conditions associated with such genomic rearrangements, in particular cancers, such as lung cancer.