公开(公告)号：US10392379B2

公开(公告)日：2019-08-27

申请号：US15760343

申请日：2016-09-15

Applicant: Assembly Biosciences, Inc. ,  INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： William Turner ,  Lee Daniel Arnold ,  Hans Maag ,  Mark Bures

IPC: C07D243/38 ,  C07D267/20 ,  C07D281/16 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04 ,  A61K45/06 ,  A61P31/20 ,  C07D413/12

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US20180258084A1

公开(公告)日：2018-09-13

申请号：US15760284

申请日：2016-09-15

Applicant: Assembly Biosciences, Inc. ,  INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： William Turner ,  Lee Daniel Arnold ,  Hans Maag ,  Leping Li ,  Mark Bures ,  Simon Haydar ,  Samson Francis

IPC: C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04

CPC classification number: C07D417/12 ,  A61K45/06 ,  A61P31/20 ,  C07D243/38 ,  C07D267/20 ,  C07D281/16 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US10947224B2

公开(公告)日：2021-03-16

申请号：US15965655

申请日：2018-04-27

Applicant: Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

Inventor： William W. Turner, Jr. ,  Lee Daniel Arnold ,  Hans Maag ,  Adam Zlotnick

IPC: A61P31/12 ,  C07D417/12 ,  C07D403/12 ,  C07D223/20 ,  C07D401/12 ,  C07D413/12 ,  C07D243/38 ,  C07D281/14 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/553 ,  A61K31/554 ,  A61K45/06 ,  C07D281/16

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US10273228B2

公开(公告)日：2019-04-30

申请号：US15566633

申请日：2016-04-15

Applicant: Indiana University Research and Technology Corporation

Inventor： Lee Daniel Arnold ,  Hans Maag ,  William W. Turner, Jr.

IPC: C07D403/14 ,  C07D401/04 ,  C07D403/12 ,  C07D401/12 ,  C07D403/04 ,  C07D239/42 ,  C07D239/48 ,  C07D409/12 ,  C07D417/04 ,  C07D417/12 ,  C07D401/14 ,  C07D417/14 ,  C07D213/74 ,  C07D239/47 ,  C07D413/04 ,  A61K31/496 ,  A61K31/506 ,  A61P31/20

Abstract: Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.

公开(公告)号：US20230019129A1

公开(公告)日：2023-01-19

申请号：US17154721

申请日：2021-01-21

Applicant: Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

Inventor： William W. Turner, JR. ,  Lee Daniel Arnold ,  Hans Maag ,  Adam Zlotnick

IPC: C07D417/12 ,  C07D403/12 ,  C07D223/20 ,  C07D401/12 ,  C07D413/12 ,  C07D243/38 ,  C07D281/14 ,  A61P31/12 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/553 ,  A61K31/554 ,  A61K45/06 ,  C07D281/16

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US10377748B2

公开(公告)日：2019-08-13

申请号：US15760284

申请日：2016-09-15

Applicant: Assembly Biosciences, Inc. ,  INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： William Turner ,  Lee Daniel Arnold ,  Hans Maag ,  Leping Li ,  Mark Bures ,  Simon Haydar ,  Samson Francis

IPC: C07D417/12 ,  A61P31/20 ,  C07D403/12 ,  A61K45/06 ,  C07D401/12 ,  C07D413/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04 ,  C07D243/38 ,  C07D267/20 ,  C07D281/16

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US20170266197A1

公开(公告)日：2017-09-21

申请号：US15310070

申请日：2015-05-11

Applicant: Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

Inventor： Adam Zlotnick ,  William W. Turner ,  Lee Daniel Arnold

IPC: A61K31/5377 ,  A61K31/506 ,  G01N33/50 ,  A61K31/445 ,  G01N33/576 ,  A61K45/06 ,  A61K31/18

CPC classification number: A61K31/5377 ,  A61K31/18 ,  A61K31/445 ,  A61K31/506 ,  A61K31/713 ,  A61K45/06 ,  G01N33/5023 ,  G01N33/5032 ,  G01N33/5762 ,  G01N2500/04

Abstract: Described herein are methods for identifying compounds useful for the treatment of infection by hepatitis B virus (HBV) and for identifying compounds useful for the same.

公开(公告)号：US10183936B2

公开(公告)日：2019-01-22

申请号：US15125911

申请日：2015-03-13

Applicant: Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

Inventor： William W. Turner, Jr. ,  Lee Daniel Arnold ,  Hans Maag ,  Adam Zlotnick

IPC: C07D417/12 ,  C07D403/12 ,  C07D223/20 ,  C07D401/12 ,  C07D413/12 ,  C07D243/38 ,  C07D281/14 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/553 ,  A61K31/554 ,  A61K45/06 ,  C07D281/16

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US20180273521A1

公开(公告)日：2018-09-27

申请号：US15965655

申请日：2018-04-27

Applicant: Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

Inventor： William W. Turner, JR. ,  Lee Daniel Arnold ,  Hans Maag ,  Adam Zlotnick

IPC: C07D417/12 ,  C07D281/14 ,  A61K45/06 ,  C07D281/16 ,  A61K31/554 ,  C07D401/12 ,  A61K31/5513 ,  A61K31/553 ,  C07D413/12 ,  C07D223/20 ,  C07D403/12 ,  A61K31/55 ,  C07D243/38

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US20180273520A1

公开(公告)日：2018-09-27

申请号：US15760343

申请日：2016-09-15

Applicant: Assembly Biosciences, Inc. ,  INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： William Turner ,  Lee Daniel Arnold ,  Hans Maag ,  Mark Bures

IPC: C07D417/12 ,  C07D417/14 ,  A61P31/20

CPC classification number: C07D417/12 ,  A61K45/06 ,  A61P31/20 ,  C07D243/38 ,  C07D267/20 ,  C07D281/16 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.