公开(公告)号：US20180078559A1

公开(公告)日：2018-03-22

申请号：US15557796

申请日：2016-03-14

Applicant: Rita Maria Cunha de Almeida ,  Indiana University Research and Technology Corporation

Inventor： Robert Bacallao ,  James A. Glazier ,  Sherry G. Clendenon ,  Rita Maria Cunha De Almeida

IPC: A61K31/53 ,  A61K31/519 ,  A61K31/4985 ,  C12Q1/68

CPC classification number: A61K31/53 ,  A61K31/4985 ,  A61K31/519 ,  A61K45/06 ,  C12Q1/44 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2333/916 ,  G01N2800/347

Abstract: Described herein is the identification of cGMP-specific phosphodiesterase upregulation in cystic kidney diseases. Also described is the use of cGMP-specific phosphodiesterase inhibitors for preventing the progression and/or treatment of cystic kidney diseases. Other aspects described provide medicaments for preventing the progression and/or treating cystic kidney diseases, and methods of diagnosing cystic kidney disease.

公开(公告)号：US10821437B2

公开(公告)日：2020-11-03

申请号：US16105002

申请日：2018-08-20

Applicant: Indiana University Research and Technology Corporation

Inventor： James A. Glazier ,  Stephen C. Jacobson ,  Dragos Amarie

IPC: B01L3/00 ,  B01F5/06 ,  B01F15/04 ,  B01F13/00 ,  B01F3/08

Abstract: Disclosed is a method and apparatus for manipulating fluids. The apparatus may include a microfluidic structure including inlet channels (1 and 2) and outlet channels (306, 307, 308, 309, 310, 311, 312, 313, and 314) oriented among bifurcated (5), trifurcated (6) and merging junctions (7 and 8). The apparatus splits and merges fluids flowing in the channels to produce successive dilutions of the fluids within the outlet channels. Multiple apparatus may be combined in serial, parallel, combined serial and parallel and/or stacked configurations. One or more apparatus may be used alone or to provide various devices or chambers with the diluted fluids.

公开(公告)号：US10196596B2

公开(公告)日：2019-02-05

申请号：US15050356

申请日：2016-02-22

Applicant: Indiana University Research and Technology Corporation

Inventor： James A. Glazier ,  Abdelkrim Alileche ,  Abbas Shirinifard ,  Dragos Amarie

IPC: C12M3/00 ,  C12M1/22 ,  C12M1/00 ,  A61K35/44 ,  C12N5/00

Abstract: Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined geometries and ECM and basement membrane associated with the capillary networks. The capillary networks and the ECM and basement membrane detachable from the capillary networks are useful for tissue engineering applications.

公开(公告)号：US10052628B2

公开(公告)日：2018-08-21

申请号：US15198359

申请日：2016-06-30

Applicant: Indiana University Research and Technology Corporation

Inventor： James A. Glazier ,  Stephen C. Jacobson ,  Dragos Amarie

IPC: B01L3/00 ,  B01F5/00 ,  B01F13/00 ,  B01F5/06 ,  B01F15/04 ,  B01F3/08

CPC classification number: B01L3/502715 ,  B01F3/0865 ,  B01F5/06 ,  B01F5/0601 ,  B01F13/0059 ,  B01F13/0062 ,  B01F15/0404 ,  B01F2003/0896 ,  B01F2215/0037 ,  B01L3/502776 ,  B01L2200/0694 ,  B01L2200/12 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0896 ,  B01L2400/0415

Abstract: Disclosed is a method and apparatus for manipulating fluids. The apparatus may include a microfluidic structure including inlet channels (1 and 2) and outlet channels (306, 307, 308, 309, 310, 311, 312, 313, and 314) oriented among bifurcated (5), trifurcated (6) and merging junctions (7 and 8). The apparatus splits and merges fluids flowing in the channels to produce successive dilutions of the fluids within the outlet channels. Multiple apparatus may be combined in serial, parallel, combined serial and parallel and/or stacked configurations. One or more apparatus may be used alone or to provide various devices or chambers with the diluted fluids.

公开(公告)号：US10456404B2

公开(公告)日：2019-10-29

申请号：US15557796

申请日：2016-03-14

Applicant: Indiana University Research and Technology Corporation ,  Rita Maria Cunha de Almeida ,  United States Government as Represented by the Department of Veterans Affairs

Inventor： Robert Bacallao ,  James A. Glazier ,  Sherry G. Clendenon ,  Rita Maria Cunha De Almeida

IPC: A61K31/4985 ,  C12Q1/44 ,  G01N33/68 ,  A61K31/53 ,  C12Q1/6883 ,  A61K31/519 ,  A61K45/06

Abstract: Described herein is the identification of cGMP-specific phosphodiesterase upregulation in cystic kidney diseases. Also described is the use of cGMP-specific phosphodiesterase inhibitors for preventing the progression and/or treatment of cystic kidney diseases. Other aspects described provide medicaments for preventing the progression and/or treating cystic kidney diseases, and methods of diagnosing cystic kidney disease.

公开(公告)号：US10973686B2

公开(公告)日：2021-04-13

申请号：US16071353

申请日：2017-01-20

Applicant: Indiana University Research and Technology Corporation

Inventor： Thomas J. Gast ,  Xiao Fu ,  James A. Glazier

IPC: A61F9/008 ,  A61B34/10 ,  A61B3/12 ,  A61B5/00

Abstract: This disclosure relates to methods for treatment or prevention of retinal vascular disease by photocoagulation. More specifically, this disclosure relates to an improved technique for the placement of retinal burns so as to prevent the development of hypoxia and progression of ischemia in retinal tissue, including the macula. The methods can also be employed to prevent potential ischemic tissue damage in diabetic, pre-diabetic or other patients with ischemic retinal vascular disease, or those at risk of ischemic retinal vascular disease.