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1.发明授权Method of fabricating porous membrane with unique pore structure for aerosolized delivery of drugs 有权制造具有独特孔结构的多孔膜用于药物雾化递送的方法公开(公告)号：US06551542B1
公开(公告)日：2003-04-22
申请号：US09710612
申请日：2000-11-08
IPC分类号： B23K2600
CPC分类号： B23K26/382 , B23K26/066 , B23K26/40 , B23K2103/42 , B23K2103/50
摘要： A method for producing a nozzle useful in generating a fine aerosol for delivery of therapeutic or diagnostic agents is provided. The method comprises focusing a laser source onto a thin, preferably flexible material so as to form pores substantially through the material. The pores are formed to have an unflexed exit aperture diameter in the range of about 0.5 to about 25 microns, depending on the size of the aerosol particles desired for a particular application. The nozzle may have a variety of shapes and be distributed in a variety of patterns. An elevated area can be formed around the exit aperture of the nozzle in order to prevent intrusion of liquid into the nozzle.
摘要翻译： 提供了一种用于生成用于产生用于递送治疗剂或诊断剂的细小气溶胶的喷嘴的方法。 该方法包括将激光源聚焦到薄的，优选柔性的材料上，以形成基本上通过该材料的孔。 根据特定应用所需的气溶胶颗粒的尺寸，孔被形成为具有约0.5至约25微米范围内的非折射出口孔直径。 喷嘴可以具有各种形状并且以各种图案分布。 可以在喷嘴的出口孔周围形成升高的区域，以防止液体进入喷嘴。
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公开(公告)号：US06543442B2
公开(公告)日：2003-04-08
申请号：US09798083
申请日：2001-03-02
申请人： Igor Gonda , Jeffrey A. Schuster , Rajesh S. Patel
发明人： Igor Gonda , Jeffrey A. Schuster , Rajesh S. Patel
IPC分类号： A61M1100
CPC分类号： A61M15/0045 , A61M11/002 , A61M15/0043 , A61M15/0051 , A61M15/0055
摘要： A nozzle comprised of a thin, flexible membrane material having a plurality of pores is disclosed. In one embodiment, the pores have an unflexed exit aperture diameter in the range of about 0.5 to about 2 microns (preferably about 1 micron) and are positioned substantially uniformly in the material, preferably about 50 microns apart. The nozzle preferably has a conical or trumpet-shaped cross-section. In another aspect of the invention, the exit aperture of the nozzle is surrounded by an elevated area protruding above the substantially planar exit side of the membrane in order to prevent intrusion of liquid back into the nozzle. The nozzle can be used to form an aerosol containing a pharmaceutical composition from the exit side of the nozzle upon forcible application of the composition to the entrance side of the nozzle. This aerosol can be used to administer the pharmaceutical composition, for example, to the eye or to a selected portion of the respiratory tract. The nozzle is preferably a component of a container which holds a formulation of drug.
摘要翻译： 公开了一种由具有多个孔的薄的柔性膜材料构成的喷嘴。 在一个实施方案中，孔具有在约0.5至约2微米（优选约1微米）范围内的非折射出口孔径，并且基本上均匀地定位在材料中，优选地相隔约50微米。 喷嘴优选地具有锥形或喇叭形横截面。 在本发明的另一方面，喷嘴的出口孔被突出在膜的基本上平面的出口侧上方的升高区域围绕，以防止液体侵入喷嘴中。 喷嘴可以在将组合物强制施加到喷嘴的入口侧时，从喷嘴的出口侧形成含有药物组合物的气溶胶。 该气溶胶可用于将药物组合物施用于例如眼睛或呼吸道的选定部分。 喷嘴优选地是容纳药物制剂的容器的组分。
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公开(公告)号：US6070575A
公开(公告)日：2000-06-06
申请号：US192833
申请日：1998-11-16
申请人： Igor Gonda , Jeffrey A. Schuster , Rajesh S. Patel
发明人： Igor Gonda , Jeffrey A. Schuster , Rajesh S. Patel
CPC分类号： A61M15/0045 , A61M15/0043 , A61M15/0051 , A61M15/0055 , A61M11/002
摘要： A nozzle comprised of a thin, flexible membrane material having a plurality of pores is disclosed. In one embodiment, the pores have an unflexed exit aperture diameter in the range of about 0.5 to about 2 microns (preferably about 1 micron) and are positioned substantially uniformly in the material, preferably about 50 microns apart. The nozzle preferably has a conical or trumpet-shaped cross-section. In another aspect of the invention, the exit aperture of the nozzle is surrounded by an elevated area protruding above the substantially planar exit side of the membrane in order to prevent intrusion of liquid back into the nozzle. The nozzle can be used to form an aerosol containing a pharmaceutical composition from the exit side of the nozzle upon forcible application of the composition to the entrance side of the nozzle. This aerosol can be used to administer the pharmaceutical composition, for example, to the eye or to a selected portion of the respiratory tract. The nozzle is preferably a component of a container which holds a formulation of drug.
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4.发明授权Method and device for creating aerosol with porous membrane with certain pore structure 有权用具有一定孔隙结构的多孔膜产生气溶胶的方法和装置公开(公告)号：US06230706B1
公开(公告)日：2001-05-15
申请号：US09586713
申请日：2000-06-05
申请人： Igor Gonda , Jeffrey A. Schuster , Rajesh S. Patel
发明人： Igor Gonda , Jeffrey A. Schuster , Rajesh S. Patel
IPC分类号： A61M1500
CPC分类号： A61M15/0045 , A61M11/002 , A61M15/0043 , A61M15/0051 , A61M15/0055
摘要： A nozzle comprised of a thin, flexible membrane material having a plurality of pores is disclosed. In one embodiment, the pores have an unflexed exit aperture diameter in the range of about 0.5 to about 2 microns (preferably about 1 micron) and are positioned substantially uniformly in the material, preferably about 50 microns apart. The nozzle preferably has a conical or trumpet-shaped cross-section. In another aspect of the invention, the exit aperture of the nozzle is surrounded by an elevated area protruding above the substantially planar exit side of the membrane in order to prevent intrusion of liquid back into the nozzle. The nozzle can be used to form an aerosol containing a pharmaceutical composition from the exit side of the nozzle upon forcible application of the composition to the entrance side of the nozzle. This aerosol can be used to administer the pharmaceutical composition, for example, to the eye or to a selected portion of the respiratory tract. The nozzle is preferably a component of a container which holds a formulation of drug.
摘要翻译： 公开了一种由具有多个孔的薄的柔性膜材料构成的喷嘴。 在一个实施方案中，孔具有在约0.5至约2微米（优选约1微米）范围内的非折射出口孔径，并且基本上均匀地定位在材料中，优选地相隔约50微米。 喷嘴优选地具有锥形或喇叭形横截面。 在本发明的另一方面，喷嘴的出口孔被突出在膜的基本上平面的出口侧上方的升高区域围绕，以防止液体侵入喷嘴中。 喷嘴可以在将组合物强制施加到喷嘴的入口侧时，从喷嘴的出口侧形成含有药物组合物的气溶胶。 该气溶胶可用于将药物组合物施用于例如眼睛或呼吸道的选定部分。 喷嘴优选地是容纳药物制剂的容器的组分。
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5.发明授权公开(公告)号：US06624885B1
公开(公告)日：2003-09-23
申请号：US09330254
申请日：1999-06-10
申请人： Russell M. Pon , Rajesh S. Patel , James M. Bovatsek , Jeffrey A. Schuster , Geoffrey K. McKinley , Sze-The Young
发明人： Russell M. Pon , Rajesh S. Patel , James M. Bovatsek , Jeffrey A. Schuster , Geoffrey K. McKinley , Sze-The Young
IPC分类号： G01N2100
CPC分类号： G01N21/894 , B23K26/032 , B23K26/0846 , B23K26/128 , B23K26/382 , G01N21/8851
摘要： A method for inspecting small holes in a material is disclosed. The method comprises directing a light source through the holes in the material, and then focusing the light passing through the material onto a CCD detector. The focusing techniques allow for a reduction in the size of the image which must be inspected, thereby increasing sample throughput, while still allowing for detailed inspection of the hole number and quality. Methods of producing an aerosolization container and device comprising membranes which pass such an inspection are also provided.
摘要翻译： 公开了一种用于检查材料中的小孔的方法。 该方法包括将光源引导通过材料中的孔，然后将通过材料的光聚焦到CCD检测器上。 聚焦技术允许减小必须检查的图像的尺寸，从而增加样品通量，同时仍然允许详细检查孔数和质量。 还提供了生产雾化容器的方法和包括通过这种检查的膜的装置。
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公开(公告)号：US5536605A
公开(公告)日：1996-07-16
申请号：US446356
申请日：1995-05-22
摘要： A repaired laser ablation mask is disclosed capable of withstanding laser fluences in the range from about 200 mJ/cm.sup.2 to at least 500 mJ/cm.sup.2. The repaired mask comprises a single or multiple layers of apertured metal, such as, aluminum, on a quartz substrate. The laser mask repair technique and structure are also disclosed. The thickness of the metal layer, such as, aluminum layer, is in the range from about 2 microns to about 6 microns. A laser projection etching technique is also disclosed for using the repaired ablation mask.
摘要翻译： 所公开的修复的激光烧蚀掩模能够承受在约200mJ / cm 2至至少500mJ / cm 2范围内的激光能量密度。 被修复的掩模包括在石英衬底上的单层或多层有孔金属，例如铝。 还公开了激光掩模修复技术和结构。 金属层（例如铝层）的厚度在约2微米至约6微米的范围内。 还公开了使用修复的消融掩模的激光投影蚀刻技术。
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7.发明授权Femtosecond laser processing system with process parameters, controls and feedback 有权飞秒激光加工系统具有工艺参数，控制和反馈公开(公告)号：US08279903B2
公开(公告)日：2012-10-02
申请号：US13025408
申请日：2011-02-11
申请人： Lawrence Shah , James M. Bovatsek , Alan Y. Arai , Tadashi Yamamoto , Rajesh S. Patel , Donald J. Harter
发明人： Lawrence Shah , James M. Bovatsek , Alan Y. Arai , Tadashi Yamamoto , Rajesh S. Patel , Donald J. Harter
IPC分类号： H01S3/13
CPC分类号： H01S3/10038 , G01J11/00 , H01S3/0014 , H01S3/005 , H01S3/0057 , H01S3/0064 , H01S3/0078 , H01S3/06754 , H01S3/10023 , H01S3/10061 , H01S3/102 , H01S3/1024 , H01S3/108 , H01S3/109 , H01S3/1305 , H01S3/1618
摘要： A femtosecond laser based laser processing system having a femtosecond laser, frequency conversion optics, beam manipulation optics, target motion control, processing chamber, diagnostic systems and system control modules. The femtosecond laser based laser processing system allows for the utilization of the unique heat control in micromachining, and the system has greater output beam stability, continuously variable repetition rate and unique temporal beam shaping capabilities.
摘要翻译： 飞秒激光激光处理系统，具有飞秒激光，变频光学，光束操纵光学，目标运动控制，处理室，诊断系统和系统控制模块。 基于飞秒激光的激光加工系统允许在微加工中利用独特的热控制，并且该系统具有更大的输出光束稳定性，连续可变的重复率和独特的时间波束整形能力。
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8.发明授权公开(公告)号：US07491909B2
公开(公告)日：2009-02-17
申请号：US10813389
申请日：2004-03-31
IPC分类号： B23K26/38
CPC分类号： B23K26/0624 , B23K26/0622
摘要： A method for laser machining of material using a burst comprised of laser pulses. The method tailors the pulse width, pulse separation duration, wavelength and polarization of the multiple laser pulses included in a burst to maximize the positive effect of thermal and physical changes achieved by previous pulses that have impinged upon the machined material.
摘要翻译： 使用由激光脉冲组成的脉冲激光加工材料的方法。 该方法调整脉冲包括的脉冲宽度，脉冲间隔持续时间，波长和多个激光脉冲的极化，以最大限度地发挥已经冲击加工材料的先前脉冲实现的热和物理变化的积极作用。
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公开(公告)号：US07316360B2
公开(公告)日：2008-01-08
申请号：US10808046
申请日：2004-03-23
CPC分类号： A61M15/009 , A61M15/0031 , A61M15/0043 , A61M15/0045 , A61M15/0051 , A61M15/0055 , Y10T29/49826
摘要： A nozzle comprising a thin, flexible substantially planar polymeric film having a plurality of pores with structures allowing for generation of an aerosol at reduced extrusion pressure is disclosed. The pores can comprise at least two sections, or steps, in which the thickness of the membrane is reduced in stepwise fashion, or the pores can be tapered. Nozzles formed comprising pores having such structures permit aerosol generation at lower extrusion pressures, thereby allowing for decreased weight of aerosolization devices, increased efficiency, increased portability and increased battery life. The pore structures also allow for the use of thicker, more easily processed polymeric films in manufacturing while having a thinner, more efficient aerosolization area. The use of decreased extrusion pressures also results in increased uniformity in aerosol generation and improved reliability of other components.
摘要翻译： 公开了一种喷嘴，其包括薄的柔性基本平坦的聚合物膜，其具有多个具有允许以降低的挤压压力产生气溶胶的结构的孔。 孔可以包括至少两个部分或步骤，其中膜的厚度以逐步的方式减小，或者孔可以是锥形的。 形成的包括具有这种结构的孔的喷嘴允许在较低的挤出压力下产生气溶胶，从而允许雾化装置的重量减少，提高的效率，增加的便携性和延长的电池寿命。 孔结构还允许在制造中使用更厚，更容易加工的聚合物膜，同时具有更薄，更有效的雾化区域。 使用降低的挤出压力还导致气溶胶产生的均匀性增加和其他组分的可靠性提高。
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公开(公告)号：US06855909B2
公开(公告)日：2005-02-15
申请号：US10733072
申请日：2003-12-10
CPC分类号： A61M15/0045 , A61M15/0031 , A61M15/0043 , A61M15/0051 , A61M15/0055
摘要： A nozzle comprising a thin, flexible substantially planar polymeric film having a plurality of pores with structures allowing for generation of an aerosol at reduced extrusion pressure is disclosed. The pores can comprise at least two sections, or steps, in which the thickness of the membrane is reduced in stepwise fashion, or the pores can be tapered. Nozzles formed comprising pores having such structures permit aerosol generation at lower extrusion pressures, thereby allowing for decreased weight of aerosolization devices, increased efficiency, increased portability and increased battery life. The pore structures also allow for the use of thicker, more easily processed polymeric films in manufacturing while having a thinner, more efficient aerosolization area. The use of decreased extrusion pressures also results in increased uniformity in aerosol generation and improved reliability of other components.
摘要翻译： 公开了一种喷嘴，其包括薄的柔性基本平坦的聚合物膜，其具有多个具有允许以降低的挤压压力产生气溶胶的结构的孔。 孔可以包括至少两个部分或步骤，其中膜的厚度以逐步的方式减小，或者孔可以是锥形的。 形成的包括具有这种结构的孔的喷嘴允许在较低的挤出压力下产生气溶胶，从而允许雾化装置的重量减少，提高的效率，增加的便携性和延长的电池寿命。 孔结构还允许在制造中使用更厚，更容易加工的聚合物膜，同时具有更薄，更有效的雾化区域。 使用降低的挤出压力还导致气溶胶产生的均匀性增加和其他组分的可靠性提高。
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