公开(公告)号：US12018067B2

公开(公告)日：2024-06-25

申请号：US18150957

申请日：2023-01-06

申请人： Theraclone Sciences, Inc. ,  International AIDS Vaccine Initiative, Inc. ,  The Scripps Research Institute

发明人： Po-Ying Chan-Hui ,  Steven Frey ,  Ole Olsen ,  Jennifer Mitcham ,  Matthew Moyle ,  Sanjay K. Phogat ,  Dennis R. Burton ,  Laura Marjorie Walker ,  Pascal Raymond Georges Poignard ,  Wayne Koff ,  Melissa Danielle De Jean De St. Marcel Simek-Lemos ,  Stephen Kaminsky

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61P31/14 ,  C07K16/10

CPC分类号： C07K16/1045 ,  A61K39/21 ,  A61P31/14 ,  C07K16/1063 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

公开(公告)号：US20230295278A1

公开(公告)日：2023-09-21

申请号：US18150957

申请日：2023-01-06

申请人： Theraclone Sciences, Inc. ,  International AIDS Vaccine Initiative, Inc. ,  The Scripps Research Institute

发明人： Po-Ying Chan-Hui ,  Steven Frey ,  Ole Olsen ,  Jennifer Mitcham ,  Matthew Moyle ,  Sanjay K. Phogat ,  Dennis R. Burton ,  Laura Marjorie Walker ,  Pascal Raymond Georges Poignard ,  Wayne Koff ,  Melissa Danielle De Jean De St. Marcel Simek-Lemos ,  Stephen Kaminsky

IPC分类号： C07K16/10 ,  A61P31/14 ,  A61K39/21

CPC分类号： C07K16/1045 ,  C07K16/1063 ,  A61P31/14 ,  A61K39/21 ,  A61K2039/505

摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

公开(公告)号：US11891416B2

公开(公告)日：2024-02-06

申请号：US17074358

申请日：2020-10-19

申请人： INTERNATIONAL AIDS VACCINE INITIATIVE, INC.

发明人： Christopher L. Parks ,  Ivo Lorenz ,  Sanjay K. Phogat ,  Timothy J. Zamb

IPC分类号： A61K39/21 ,  C07K14/005 ,  A61K39/12 ,  C12N7/00 ,  G01N33/68 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  C12N7/00 ,  G01N33/6854 ,  A61K39/00 ,  A61K2039/5256 ,  C12N2740/16051 ,  C12N2740/16134 ,  C12N2760/20234 ,  C12N2760/20243 ,  C12N2760/20251 ,  G01N2333/162

摘要： The present relation relates to recombinant vesicular stomatitis virus for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.

公开(公告)号：US20240343782A1

公开(公告)日：2024-10-17

申请号：US18734520

申请日：2024-06-05

申请人： Theraclone Sciences, Inc. ,  International AIDS Vaccine Initiative, Inc. ,  The Scripps Research Institute

发明人： Po-Ying Chan-Hui ,  Steven Frey ,  Ole Olsen ,  Jennifer Mitcham ,  Matthew Moyle ,  Sanjay K. Phogat ,  Dennis R. Burton ,  Laura Marjorie Walker ,  Pascal Raymond Georges Poignard ,  Wayne Koff ,  Melissa Danielle De Jean De St. Marcel Simek-Lemos ,  Stephen Kaminsky

IPC分类号： C07K16/10 ,  A61K39/00 ,  A61K39/21 ,  A61P31/14

CPC分类号： C07K16/1045 ,  A61K39/21 ,  A61P31/14 ,  C07K16/1063 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

公开(公告)号：US20240132578A1

公开(公告)日：2024-04-25

申请号：US18452002

申请日：2023-08-18

申请人： INTERNATIONAL AIDS VACCINE INITIATIVE, INC. ,  THE SCRIPPS RESEARCH INSTITUTE ,  THERACLONE SCIENCES INC.

发明人： Po-Ying Chan-Hui ,  Katherine Doores ,  Michael Huber ,  Stephen Kaminsky ,  Steven Frey ,  Ole Olsen ,  Jennifer Mitcham ,  Matthew Moyle ,  Sanjay K. Phogat ,  Dennis R. Burton ,  Laura Majorie Walker ,  Pascal Raymond Georges Poignard ,  Wayne Koff ,  Melissa Danielle De Jean De St. Marcel Simek-Lemos

IPC分类号： C07K16/10 ,  A61K39/21

CPC分类号： C07K16/1063 ,  A61K39/21 ,  C07K16/1045 ,  A61K2039/505

摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

公开(公告)号：US11845789B2

公开(公告)日：2023-12-19

申请号：US17376276

申请日：2021-07-15

申请人： THERACLONE SCIENCES, INC. ,  THE SCRIPPS RESEARCH INSTITUTE ,  INTERNATIONAL AIDS VACCINE INITIATIVE, INC.

发明人： Po-Ying Chan-Hui ,  Katherine Doores ,  Michael Huber ,  Stephen Kaminsky ,  Steven Frey ,  Ole Olsen ,  Jennifer Mitcham ,  Matthew Moyle ,  Sanjay K. Phogat ,  Dennis R. Burton ,  Laura Majorie Walker ,  Pascal Raymond Georges Poignard ,  Wayne Koff ,  Melissa Danielle De Jean De St. Marcel Simek-Lemos

IPC分类号： C07K16/10 ,  A61K39/21 ,  A61K39/00 ,  A61P31/18

CPC分类号： C07K16/1063 ,  A61K39/21 ,  C07K16/1045 ,  A61K2039/505 ,  A61P31/18 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2740/16111 ,  C12N2740/16122

摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.