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公开(公告)号：US5466681A
公开(公告)日：1995-11-14
申请号：US180397
申请日：1994-01-12
IPC分类号： A61K38/17 , A61K47/48 , A61K31/715 , A61K31/705 , A61K39/00
CPC分类号： A61K47/48276 , Y10S530/813
摘要： A variety of conjugates useful for the treatment of infections due to pathogenic microorganisms are provided. The conjugates comprise at least one agent coupled to a receptor which binds a microorganism. Suitable agents include anti-infectives, such as antibiotics and synthetic drugs. The present invention also provides methods for treating infections in warm-blooded animals due to pathogenic microorganisms.
摘要翻译： 提供了可用于治疗由于病原微生物引起的感染的各种缀合物。 缀合物包含与结合微生物的受体偶联的至少一种试剂。 合适的试剂包括抗感染剂，例如抗生素和合成药物。 本发明还提供了用于治疗由于病原微生物引起的温血动物感染的方法。
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2.发明授权Method of using lectins for prevention and treatment of oral and alimentary tract disorders 失效使用凝集素预防和治疗口腔和消化道疾病的方法公开(公告)号：US08187614B2
公开(公告)日：2012-05-29
申请号：US12875826
申请日：2010-09-03
CPC分类号： A61K38/17 , A61K38/168 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/928
摘要： Infectious diseases caused by pathogenic microorganisms resident in the alimentary tract of humans and animals can be prevented and treated by administering to the alimentary tract of the human or animal an effective amount of a composition containing at least one lectin capable of binding to an infective microorganism and diminishing its infective capability of the microorganism. The lectin is administered dispensed in a pharmaceutically acceptable non-toxic vehicle. Peptic ulcer disease caused by infection with H. pylori can be treated by oral administration of lectins that bind to the pathogen. A beneficial ecology of H. pylori can be maintained in infected patients by chronic oral administration of lectins that bind to the pathogen.
摘要翻译： 可以通过向人或动物的消化道施用有效量的含有至少一种能够与感染性微生物结合的凝集素的组合物，并且可以预防和治疗由存在于人和动物消化道中的致病微生物引起的传染病， 降低微生物的感染能力。 凝集素在药学上可接受的无毒性载体中分配。 可以通过口服施用与病原体结合的凝集素来治疗由幽门螺杆菌感染引起的消化性溃疡病。 通过慢性口服施用与病原体结合的凝集素，可以在感染患者中保持幽门螺杆菌的有益生态。
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公开(公告)号：US5721115A
公开(公告)日：1998-02-24
申请号：US480993
申请日：1995-06-07
申请人： Howard C. Krivan , James E. Samuel
发明人： Howard C. Krivan , James E. Samuel
IPC分类号： A61K39/102 , C07H3/06 , C07H15/04 , C07H15/08 , C07H15/18 , C07K14/285 , C12P21/06 , C07H21/02 , C12N15/06
CPC分类号： C07H15/04 , A61K39/102 , C07H15/08 , C07H15/18 , C07H3/06 , C07K14/285 , A61K2039/6068 , A61K2039/627 , C07K2319/00
摘要： Disclosed herein are an immunogenic Haemophilus influenzae outer membrane protein of 49 kDa as well as a mature outer membrane protein of 47 kDa protein, DNA and vector useful for producing the outer membrane protein, host cell containing said DNA, and a method for producing the outer membrane protein. Also disclosed are methods for producing these materials which can be beneficially used in the production of vaccines against H. influenzae.
摘要翻译： 本文公开了49kDa的免疫原性流感嗜血杆菌外膜蛋白以及47kDa蛋白质的成熟外膜蛋白，可用于产生外膜蛋白的DNA和载体，含有所述DNA的宿主细胞，以及用于生产外部的方法 膜蛋白。 还公开了可用于生产针对流感嗜血杆菌疫苗的这些材料的生产方法。
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公开(公告)号：US5386027A
公开(公告)日：1995-01-31
申请号：US60134
申请日：1993-05-13
IPC分类号： A61K31/70 , G01N33/569 , C08B37/00 , A61K39/02
CPC分类号： G01N33/56911 , A61K31/70 , Y10S435/803 , Y10S435/851 , Y10S435/874 , Y10S435/882 , Y10S435/885
摘要： A carbohydrate receptor for pathogenic bacteria is a purified carbohydrate compound that is a member selected from the group consisting of fucosyl-asialo GM1, asialo GM1, and asialo GM2. The receptor can be included in a composition having a pharmaceutically acceptable carrier. The receptor may be used for purifying, detecting, or removing bacteria from diseased tissue. The structure of the receptor is N-acetylagalctosamine-beta-1-4-galactose-beta-1-4-glucose, abbreviated GalNAc.beta.1-4Gal.beta.1-4Glc. The receptor is present in human and animal tissues as complex molecule and can serve as the attachment site for bacterial infection. For example, fucosyl-asialo GM1, asialo GM1, and asialo GM2 are three biological molecules which occur in cell membranes and contain the carbohydrate receptor.
摘要翻译： 用于致病细菌的碳水化合物受体是选自岩藻糖基 - 脱ial GM1，脱ial GM1和唾液酸GM2的成员的纯化碳水化合物化合物。 受体可以包含在具有药学上可接受的载体的组合物中。 该受体可用于纯化，检测或从患病组织中除去细菌。 受体的结构是N-乙酰加己酰胺-β-1-4-半乳糖-β-1-4-葡萄糖，缩写为GalNAcβ1-4Galβ1-4Glc。 受体作为复合分子存在于人和动物组织中，可作为细菌感染的附着位点。 例如，岩藻糖基唾液酸GM1，脱ial GM1和脱ial GM2是发生在细胞膜中并含有碳水化合物受体的三种生物分子。
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5.发明授权Adhesion of Mycoplasma pneumoniae and Mycoplasma hominus to sulfatide 失效MYCOPLASMA PNEUMONIAE和MYCOPLASMA HOMINUS对SULFATIDE的粘附
公开(公告)号：US5089479A
公开(公告)日：1992-02-18
申请号：US277634
申请日：1988-11-28
IPC分类号： C12Q1/04 , A61K31/715 , A61K45/00 , A61K49/00 , A61P13/02 , A61P15/00 , A61P31/04 , C12Q1/24 , C12R1/01 , C12R1/35 , G01N33/569
CPC分类号： A61K31/7004 , C12Q1/24 , G01N33/56933 , Y10S435/80 , Y10S435/87
摘要： The invention is a carbohydrate receptor for Mycoplasma pneumoniae and Mycoplasma hominus and its use to detect mycoplasma in biological fluids and diseased tissue and cells. The receptor can be included in a composition having a pharmaceutically acceptable carrier. Methods are provided for purifying, detecting, or removing mycoplasma from diseased tissue or fluids. The receptor includes sulfatides, dextran sulfate, sialyloligosaccharides, and mixtures thereof.
摘要翻译： 本发明是肺炎支原体和人支原体的碳水化合物受体，其用于检测生物液体和病变组织和细胞中的支原体。 受体可以包含在具有药学上可接受的载体的组合物中。 提供了用于从患病组织或液体中纯化，检测或去除支原体的方法。 受体包括硫苷脂，硫酸葡聚糖，唾液酸低聚糖及其混合物。
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6.发明授权Method of detecting, isolating and purifying clostridium difficile toxin A and its receptors 失效检测，分离和纯化艰难梭菌毒素A及其受体的方法
公开(公告)号：US4863852A
公开(公告)日：1989-09-05
申请号：US828404
申请日：1986-02-11
申请人： Tracy D. Wilkins , Howard C. Krivan
发明人： Tracy D. Wilkins , Howard C. Krivan
IPC分类号： G01N33/569
CPC分类号： G01N33/56911 , Y10S435/803 , Y10S435/842 , Y10S436/829 , Y10S530/825
摘要： A method is provided for detecting the presence of C. difficile toxin A. Stool or other appropriate specimen is contacted with a reagent containing an available non-reducing galactose-alpha-1-3-galactosyl structure, which is a specific receptor for toxin A. The reagent may be intact cells, cell membranes, membrane fractions containing the toxin A receptor structure, glycoconjugates, as well as the purified toxin A receptor per se. Binding of toxin A is determined by conventional assay techniques. The method may also be used to isolate and purify toxin A. Conversely, immobilized toxin A is used to detect, isolate, or purify biological materials of interest containing the receptor structure.
摘要翻译： 提供了一种用于检测艰难梭菌毒素A的存在的方法A.将粪便或其它合适的标本与含有可用的非还原性半乳糖-α-1-3-半乳糖结构的试剂接触，所述非还原性半乳糖-α-1-3-半乳糖结构是毒素A的特异性受体 试剂可以是完整的细胞，细胞膜，含有毒素A受体结构的膜级分，糖缀合物，以及纯化的毒素A受体本身。 通过常规测定技术测定毒素A的结合。 该方法也可用于分离和纯化毒素A.相反，固定毒素A用于检测，分离或纯化包含受体结构的感兴趣的生物材料。
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7.发明授权Method of using lectins for prevention and treatment of oral and alimentary tract disorders 有权使用凝集素预防和治疗口腔和消化道疾病的方法公开(公告)号：US07790672B2
公开(公告)日：2010-09-07
申请号：US11413826
申请日：2006-04-28
CPC分类号： A61K38/17 , A61K38/168 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/928
摘要： Infectious diseases caused by pathogenic microorganisms resident in the alimentary tract of humans and animals can be prevented and treated by administering to the alimentary tract of the human or animal an effective amount of a composition containing at least one lectin capable of binding to an infective microorganism and diminishing its infective capability of the microorganism. The lectin is administered dispensed in a pharmaceutically acceptable non-toxic vehicle. Peptic ulcer disease caused by infection with H. pylori can be treated by oral administration of lectins that bind to the pathogen. A beneficial ecology of H. pylori can be maintained in infected patients by chronic oral administration of lectins that bind to the pathogen.
摘要翻译： 可以通过向人或动物的消化道施用有效量的含有至少一种能够与感染性微生物结合的凝集素的组合物，并且可以防止和处理由存在于人和动物消化道中的致病微生物引起的传染病， 降低微生物的感染能力。 凝集素在药学上可接受的无毒性载体中分配。 可以通过口服施用与病原体结合的凝集素来治疗由幽门螺杆菌感染引起的消化性溃疡病。 通过慢性口服施用与病原体结合的凝集素，可以在感染患者中保持幽门螺杆菌的有益生态。
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公开(公告)号：US6066338A
公开(公告)日：2000-05-23
申请号：US94679
申请日：1998-06-15
CPC分类号： A61K38/17 , A61F6/08 , A61K38/168 , A61K38/1709 , Y10S424/14 , Y10S514/841 , Y10S514/843 , Y10S514/953 , Y10S514/967
摘要： In order to prevent conception and/or the spread of sexually transmitted diseases (STD's) one or more lectins capable of binding sperm and/or the pathogenic microorganisms responsible for STD's are administered to the vagina prior to sexual intercourse. The lectins immobilize the sperm to render them incapable of fertilization and also bind to the microorganisms to render them non-pathogenic or to the cells to prevent infection by the microorganisms. Lectins can also be administered to treat sexually transmitted vaginal infections.The invention also encompasses a device for to be placed in the vault of the vagina which comprises a ring which surrounds the cervix and a membrane spanning the central aperture of the ring to prevent the direct contact of ejaculate with the cervical tissues. The device is impregnated or coated with lectins and releases them into the vaginal environment over a period of time.
摘要翻译： 为了防止性传播疾病（STD's）的受孕和/或扩散，可以在性交前向阴道施用一种或多种能够结合精子和/或负责STD的病原微生物的凝集素。 凝集素固定精子使其不能受精，并且还结合微生物使其成为非致病性或细胞以防止微生物感染。 也可以施用凝露素治疗性传播的阴道感染。 本发明还包括用于放置在阴道的拱顶中的装置，其包括围绕子宫颈的环和横跨环的中心孔的膜，以防止射精与子宫颈组织的直接接触。 该装置浸渍或涂有凝集素，并在一段时间内将其释放到阴道环境中。
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9.发明授权
公开(公告)号：US5843463A
公开(公告)日：1998-12-01
申请号：US903079
申请日：1992-06-22
申请人： Howard C. Krivan , James E. Samuel
发明人： Howard C. Krivan , James E. Samuel
IPC分类号： A61K39/102 , C07H3/06 , C07H15/04 , C07H15/08 , C07H15/18 , C07K14/285 , A61K39/02 , C07K14/00 , C12P21/04
CPC分类号： C07H15/04 , A61K39/102 , C07H15/08 , C07H15/18 , C07H3/06 , C07K14/285 , A61K2039/6068 , A61K2039/627 , C07K2319/00
摘要： Disclosed herein are immunogenic polysaccharide-H. influenzae adhesin protein conjugates, a purified H. influenzae adhesin protein and related proteins and polypeptides, DNA useful for producing the proteins, synthetic polyribosylribotol phosphate (PRP) oligosaccharides and intermediates useful for their synthesis, and methods of making and using these materials. The conjugates comprise a PRP fragment, preferably a synthetic oligosaccharide, coupled to an H. influenzae adhesin protein. The invention further comprises purified H. influenzae adhesin proteins and novel PRP oligosaccharides. The invention also comprises methods of producing these materials and using them in a vaccine to protect humans and other mammals against H. influenzae infection.
摘要翻译： 本文公开了免疫原性多糖-H。 流感嗜血杆菌粘附素蛋白质缀合物，纯化的流感嗜血杆菌粘附素蛋白质和相关蛋白质和多肽，可用于产生蛋白质的DNA，合成的聚核糖核糖核酸寡聚糖（PRP）寡糖和可用于其合成的中间体，以及制备和使用这些材料的方法。 缀合物包含与流感嗜血杆菌粘附素蛋白偶联的PRP片段，优选合成寡糖。 本发明还包括纯化的流感嗜血杆菌粘附素蛋白和新型PRP寡糖。 本发明还包括生产这些材料并在疫苗中使用它们以保护人类和其他哺乳动物免于流感嗜血杆菌感染的方法。
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公开(公告)号：US5696000A
公开(公告)日：1997-12-09
申请号：US275702
申请日：1994-07-18
申请人： Howard C. Krivan , James E. Samuel
发明人： Howard C. Krivan , James E. Samuel
IPC分类号： A61K9/08 , A61K9/127 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/395 , A61P31/04 , C07H3/06 , C07H15/10 , C07K14/00 , C07K14/005 , C07K14/195 , C07K14/41 , C07K14/705 , C07K16/00 , C07K19/00 , C12N5/10 , C12P21/00 , G01N33/53 , G01N33/566 , G01N33/569
CPC分类号： C07H15/10 , C07H3/06 , C07K14/195 , G01N33/569 , A61K38/00 , A61K39/00 , Y10S435/975
摘要： Disclosed herein are receptors for pathogenic or opportunistic microorganisms, methods of obtaining such reeptors, and methods of using such receptors for diagnostic or pharmaceutical purposes. The receptor comprises a substantially pure compound selected from the group consisting of GalB1-4GlcNAcB1-3GalB1-4GlcB1-1-X(R), GalB1-3GlcNAcB1-3GalB1-4GlcB1-1-X(R), GlcNAcB1-3GalB1-4GlcB1-1-X(R), GalB1-4GlcNAcB1-3GalB1-4Glc, GalB1-3GlcNAcB1-3GalB1-4Glc, GlcNAcB1-3GalB1-4Glc, GalB1-4GlcNAcB1-3Gal, and GalB1-3-GlcNAcB1-3Gal wherein X is sphingosine, hydroxylated sphingosine, or saturated sphingosine and R is H or an N-acyl fatty acid derivative of X such that X(R) is a ceramide. The invention further comprises proteins and polypeptides that bind to the receptors, methods of obtaining such proteins or polypeptides from natural sources or through recombinant DNA techniques, and methods of using the purified proteins and polypeptides for pharmaceutical and diagnostic purposes, preferably in a vaccine for administration to an animal or human host to protect against pathogenic or opportunistic microorganisms.
摘要翻译： 本文公开了致病或机会性微生物的受体，获得这种受体的方法，以及使用这些受体用于诊断或药物目的的方法。 受体包含选自GalB1-4GlcNAcB1-3GalB1-4GlcB1-1-X（R），GalB1-3GlcNAcB1-3GalB1-4GlcB1-1-X（R），GlcNAcB1-3GalB1-4GlcB1-1的基本上纯的化合物 -X（R），GalB1-4GlcNAcB1-3GalB1-4Glc，GalB1-3GlcNAcB1-3GalB1-4Glc，GlcNAcB1-3GalB1-4Glc，GalB1-4GlcNAcB1-3Gal和GalB1-3-GlcNAcB1-3Gal，其中X是鞘氨醇，羟基化鞘氨醇， 或饱和鞘氨醇，R为H或X的N-酰基脂肪酸衍生物，使得X（R）为神经酰胺。 本发明还包括与受体结合的蛋白质和多肽，从天然来源或通过重组DNA技术获得此类蛋白质或多肽的方法，以及使用纯化的蛋白质和多肽用于药物和诊断目的的方法，优选在用于给药的疫苗中 给予动物或人类宿主以防止病原体或机会性微生物。
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