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1.发明申请Monoclonal Antibodies Specific to Hemagglutinin from Influenza Virus H5-Subtype and Uses Thereof 有权特异于流感病毒H5亚型血凝素的单克隆抗体及其用途公开(公告)号：US20100297126A1
公开(公告)日：2010-11-25
申请号：US12677609
申请日：2008-08-26
申请人： Hong Liang Qian , Fang He , Siti Fadilah Supari , Hwei-Sing Kwang
发明人： Hong Liang Qian , Fang He , Siti Fadilah Supari , Hwei-Sing Kwang
IPC分类号： A61K39/395 , C07K16/10 , C12Q1/70 , C12N7/00 , A61P31/16
CPC分类号： C07K16/1018 , A61K39/42 , C07K2317/24 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
摘要： Monoclonal antibodies and related binding proteins that are specific for conformational epitopes of avian influenza virus K5 subtype hemagglutinin glycoprotein are provided. The antibodies can be used for the detection and treatment of H5 subtype AIV in specimens.
摘要翻译： 提供了特异于禽流感病毒K5亚型血凝素糖蛋白构象表位的单克隆抗体和相关结合蛋白。 该抗体可用于标本中H5亚型AIV的检测和治疗。
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2.发明授权Monoclonal antibodies specific to hemagglutinin from influenza virus H5-subtype and uses thereof 有权流感病毒H5亚型血凝素特异性单克隆抗体及其用途公开(公告)号：US08444986B2
公开(公告)日：2013-05-21
申请号：US12677609
申请日：2008-08-26
申请人： Hong Liang Qian , Fang He , Siti Fadilah Supari , Hwei-Sing Kwang
发明人： Hong Liang Qian , Fang He , Siti Fadilah Supari , Hwei-Sing Kwang
CPC分类号： C07K16/1018 , A61K39/42 , C07K2317/24 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
摘要： Monoclonal antibodies and related binding proteins that are specific for conformational epitopes of avian influenza virus K5 subtype hemagglutinin glycoprotein are provided. The antibodies can be used for the detection and treatment of H5 subtype AIV in specimens.
摘要翻译： 提供了特异于禽流感病毒K5亚型血凝素糖蛋白构象表位的单克隆抗体和相关结合蛋白。 该抗体可用于标本中H5亚型AIV的检测和治疗。
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公开(公告)号：US08540996B2
公开(公告)日：2013-09-24
申请号：US13610054
申请日：2012-09-11
申请人： Hong Liang Qian , Fang He , Hwei-Sing Kwang
发明人： Hong Liang Qian , Fang He , Hwei-Sing Kwang
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/34 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
摘要： Monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes or neuraminidase glycoprotein of N1 subtypes of avian influenza virus (AIV) are provided. The monoclonal antibodies and related binding proteins are useful for the detection of H5 and N1 subtypes of AIV, including H5N1 subtypes and provide means for the diagnosis, surveillance and treatment of dangerous viral infections.
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公开(公告)号：US20130004496A1
公开(公告)日：2013-01-03
申请号：US13610021
申请日：2012-09-11
申请人： Hong Liang Qian , Fang He , Hwei-Sing Kwang
发明人： Hong Liang Qian , Fang He , Hwei-Sing Kwang
IPC分类号： A61K39/42 , A61P31/16 , C12N7/00 , G01N33/577 , G01N21/64 , C07K16/10 , G01N33/569
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/34 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
摘要： Monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes or neuraminidase glycoprotein of N1 subtypes of avian influenza virus (AIV) are provided. The monoclonal antibodies and related binding proteins are useful for the detection of H5 and N1 subtypes of AIV, including H5N1 subtypes and provide means for the diagnosis, surveillance and treatment of dangerous viral infections.
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5.发明申请Monoclonal Antibodies Specific to Hemagglutinin and Neuraminidase from Influenza Virus H5-Subtype or N1-Subtype and Uses Thereof 有权特异于流感病毒H5亚型或N1亚型的血凝素和神经氨酸酶的单克隆抗体及其用途公开(公告)号：US20100266585A1
公开(公告)日：2010-10-21
申请号：US12677971
申请日：2008-09-12
申请人： Hong Liang Qian , Fang He , Hwei-Sing Kwang
发明人： Hong Liang Qian , Fang He , Hwei-Sing Kwang
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/34 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
摘要： Monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes or neuraminidase glycoprotein of N1 subtypes of avian influenza virus (AIV) are provided. The monoclonal antibodies and related binding proteins are useful for the detection of H5 and N1 subtypes of AIV, including H5N1 subtypes and provide means for the diagnosis, surveillance and treatment of dangerous viral infections.
摘要翻译： 提供了与禽流感病毒（AIV）N1亚型的H5亚型或神经氨酸酶糖蛋白的包膜糖蛋白特异性结合的单克隆抗体和相关结合蛋白。 单克隆抗体和相关结合蛋白可用于检测A5的H5和N1亚型，包括H5N1亚型，并为危险病毒感染的诊断，监测和治疗提供手段。
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6.发明授权Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus H5-subtype or N1-subtype and uses thereof 有权血液凝集素和流感病毒H5亚型或N1亚型的神经氨酸酶特异性单克隆抗体及其用途公开(公告)号：US08574581B2
公开(公告)日：2013-11-05
申请号：US13610021
申请日：2012-09-11
申请人： Hong Liang Qian , Fang He , Hwei-Sing Kwang
发明人： Hong Liang Qian , Fang He , Hwei-Sing Kwang
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/34 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
摘要： Monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes or neuraminidase glycoprotein of N1 subtypes of avian influenza virus (AIV) are provided. The monoclonal antibodies and related binding proteins are useful for the detection of H5 and N1 subtypes of AIV, including H5N1 subtypes and provide means for the diagnosis, surveillance and treatment of dangerous viral infections.
摘要翻译： 提供了与禽流感病毒（AIV）N1亚型的H5亚型或神经氨酸酶糖蛋白的包膜糖蛋白特异性结合的单克隆抗体和相关结合蛋白。 单克隆抗体和相关结合蛋白可用于检测A5的H5和N1亚型，包括H5N1亚型，并为危险病毒感染的诊断，监测和治疗提供手段。
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公开(公告)号：US08383121B2
公开(公告)日：2013-02-26
申请号：US12677971
申请日：2008-09-12
申请人： Hong Liang Qian , Fang He , Hwei-Sing Kwang
发明人： Hong Liang Qian , Fang He , Hwei-Sing Kwang
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/34 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
摘要： Monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes or neuraminidase glycoprotein of N1 subtypes of avian influenza virus (AIV) are provided. The monoclonal antibodies and related binding proteins are useful for the detection of H5 and N1 subtypes of AIV, including H5N1 subtypes and provide means for the diagnosis, surveillance and treatment of dangerous viral infections.
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8.发明申请MONOCLONAL ANTIBODIES SPECIFIC TO HEMAGGLUTININ AND NEURAMINIDASE FROM INFLUENZA VIRUS H5-SUBTYPE OR N1-SUBTYPE AND USES THEREOF 有权来自流感病毒H5亚型或N1亚型的HEMAGGLUTININ和神经酰胺糖酶的单克隆抗体及其用途公开(公告)号：US20130004497A1
公开(公告)日：2013-01-03
申请号：US13610054
申请日：2012-09-11
申请人： Hong Liang Qian , Fang He , Hwei-Sing Kwang
发明人： Hong Liang Qian , Fang He , Hwei-Sing Kwang
IPC分类号： A61K39/42 , A61P31/16 , C12N7/00 , G01N33/577 , G01N21/64 , C07K16/10 , G01N33/569
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/34 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
摘要： Monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes or neuraminidase glycoprotein of N1 subtypes of avian influenza virus (AIV) are provided. The monoclonal antibodies and related binding proteins are useful for the detection of H5 and N1 subtypes of AIV, including H5N1 subtypes and provide means for the diagnosis, surveillance and treatment of dangerous viral infections.
摘要翻译： 提供了与禽流感病毒（AIV）N1亚型的H5亚型或神经氨酸酶糖蛋白的包膜糖蛋白特异性结合的单克隆抗体和相关结合蛋白。 单克隆抗体和相关结合蛋白可用于检测A5的H5和N1亚型，包括H5N1亚型，并为危险病毒感染的诊断，监测和治疗提供手段。
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9.发明申请H5 Subtype-Specific Binding Proteins Useful for H5 Avian Influenza Diagnosis and Surveillance 有权H5亚型特异性结合蛋白可用于H5禽流感诊断和监测公开(公告)号：US20110003278A1
公开(公告)日：2011-01-06
申请号：US12599616
申请日：2007-05-11
申请人： Yuen Fern Ho , Qing Yun Du , Fang He , Jimmy Hwei-Sing Kwang
发明人： Yuen Fern Ho , Qing Yun Du , Fang He , Jimmy Hwei-Sing Kwang
CPC分类号： G01N33/56983 , C07K16/1018 , C07K2317/34 , C07K2317/76 , G01N2333/11
摘要： The invention provides monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes of avian influenza virus (“AIV”). The monoclonal antibodies and related binding proteins are useful for the detection of H5 subtypes of AIV, including the pathogenic H5N1 subtypes. Virus may be detected in formalin preserved, paraffin embeded specimens as well as frozen specimens and biological fluids. Accordingly, the invention provides means for the diagnosis and surveillance of dangerous viral infections.
摘要翻译： 本发明提供了与禽流感病毒（“AIV”）的H5亚型的包膜糖蛋白特异性结合的单克隆抗体和相关结合蛋白。 单克隆抗体和相关结合蛋白可用于检测AIV的H5亚型，包括致病性H5N1亚型。 可以在福尔马林保存的石蜡包埋样品以及冷冻标本和生物液体中检测病毒。 因此，本发明提供了用于诊断和监测危险病毒感染的手段。
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10.发明授权H5 subtype-specific binding proteins useful for H5 avian influenza diagnosis and surveillance 有权H5亚型特异性结合蛋白可用于H5禽流感诊断和监测公开(公告)号：US08637645B2
公开(公告)日：2014-01-28
申请号：US13613813
申请日：2012-09-13
申请人： Yuen Fern Ho , Qing Yun Du , Fang He , Jimmy Hwei-Sing Kwang
发明人： Yuen Fern Ho , Qing Yun Du , Fang He , Jimmy Hwei-Sing Kwang
IPC分类号： A61K39/395 , C12Q1/70 , C07K16/10 , C12N7/00 , G01N21/64 , G01N33/569 , G01N33/577 , A61K39/145 , A61K39/42
CPC分类号： G01N33/56983 , C07K16/1018 , C07K2317/34 , C07K2317/76 , G01N2333/11
摘要： The invention provides monoclonal antibodies and related binding proteins that bind specifically to the envelope glycoprotein of H5 subtypes of avian influenza virus (“AIV”). The monoclonal antibodies and related binding proteins are useful for the detection of H5 subtypes of AIV, including the pathogenic H5N1 subtypes. Virus may be detected in formalin preserved, paraffin embedded specimens as well as frozen specimens and biological fluids. Accordingly, the invention provides for the diagnosis and surveillance of dangerous viral infections.
摘要翻译： 本发明提供了与禽流感病毒（“AIV”）的H5亚型的包膜糖蛋白特异性结合的单克隆抗体和相关结合蛋白。 单克隆抗体和相关结合蛋白可用于检测AIV的H5亚型，包括致病性H5N1亚型。 可以在福尔马林保存，石蜡包埋的标本以及冷冻标本和生物液体中检测病毒。 因此，本发明提供危险病毒感染的诊断和监测。
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