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公开(公告)号：US20240279355A1
公开(公告)日：2024-08-22
申请号：US18318406
申请日：2023-05-16
Applicant: Hoffmann-La Roche Inc.
Inventor： Thomas HOFER , Maximiliane KOENIG , Ekkehard MOESSNER , Jens NIEWOEHNER , Tina WEINZIERL , Laurent LARIVIERE
CPC classification number: C07K16/3069 , A61P35/00 , C07K16/2809 , C07K2317/31 , C07K2317/55 , C07K2317/565
Abstract: The present invention generally relates to antibodies that bind to STEAP-1, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.
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公开(公告)号：US20230192793A1
公开(公告)日：2023-06-22
申请号：US17787168
申请日：2020-12-18
Applicant: Hoffmann-La Roche Inc. , Monash University
Inventor： Georg TIEFENTHALER , Alexander BUJOTZEK , Laurent LARIVIERE , Felix SCHUMACHER , Andrew ELLISDON , Claudia NOLD , Marcel NOLD , James WHISSTOCK
CPC classification number: C07K14/54 , A61K47/6811 , C12N15/85
Abstract: The present invention relates to polypeptides, particularly fusion protein variants comprising interleukin-37 (IL-37) and related therapeutics and compositions thereof. More particularly, the invention relates to fusion proteins comprising a mutant IL-37 polypeptide and an Fc region of an antibody. The biophysical stability such as thermal stability of said fusion proteins can be improved compared to a reference IL-37 construct, such as a wild-type IL-37 polypeptide or a mutant variant of an IL-37 polypeptide. It also relates to the fusion polypeptide variants and compositions for use in treating inflammatory diseases or conditions. In addition, the present invention relates to nucleic acid molecules encoding such fusion proteins, and vectors and host cells comprising such nucleic acid molecules.
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公开(公告)号：US20240317879A1
公开(公告)日：2024-09-26
申请号：US18732998
申请日：2024-06-04
Applicant: Hoffmann-La Roche Inc.
Inventor： Harald DUERR , Sebastian FENN , Ulrich GOEPFERT , Sabine IMHOF-JUNG , Christian KLEIN , Laurent LARIVIERE , Michael MOLHOJ , Joerg Thomas REGULA , Petra RUEGER , Wolfgang SCHAEFER
CPC classification number: C07K16/2887 , A61P25/00 , C07K16/2881 , C07K2317/31 , C07K2317/515 , C07K2317/522 , C07K2317/55 , C07K2317/66 , C07K2317/92 , C07K2317/94
Abstract: Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.
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Patent Agency Ranking
公开(公告)号：US20180282409A1
公开(公告)日：2018-10-04
申请号：US15763868
申请日：2016-09-30
Applicant: Hoffmann-La Roche Inc.
Inventor： Claudia FERRARA KOLLER , Guy GEORGES , Alexander HAAS , Hubert KETTENBERGER , Ekkehard MOESSNER , Tilman SCHLOTHAUER , Michael MOLHOJ , Laurent LARIVIERE
IPC: C07K16/28
Abstract: Herein is reported an antibody that specifically binds to human CD 19, wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO: 03, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO: 11, (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO: 05, (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO: 20 or 28, (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO: 07, and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO: 08, as well as methods of using the same.
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公开(公告)号：US20180222993A1
公开(公告)日：2018-08-09
申请号：US15941524
申请日：2018-03-30
Applicant: Hoffmann-La Roche Inc.
Inventor： Harald DUERR , Sebastian FENN , Ulrich GOEPFERT , Sabine IMHOF-JUNG , Christian KLEIN , Laurent LARIVIERE , Michael MOLHOJ , Joerg Thomas REGULA , Petra RUEGER , Wolfgang SCHAEFER
CPC classification number: C07K16/2887 , A61P25/00 , C07K16/2881 , C07K2317/31 , C07K2317/515 , C07K2317/522 , C07K2317/55 , C07K2317/66 , C07K2317/92 , C07K2317/94
Abstract: Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US20230331796A1
公开(公告)日：2023-10-19
申请号：US17850922
申请日：2022-06-27
Applicant: Hoffmann-La Roche Inc.
Inventor： Alexander KNAUPP , Laurent LARIVIERE , Petra RUEGER , Tilman SCHLOTHAUER , Stefan SEEBER
CPC classification number: C07K14/472 , B01D15/3809 , C07K1/22 , C07K16/18 , C07K2317/92 , C07K2317/94 , C07K2319/00
Abstract: Herein is reported a fusion polypeptide according to formula I (TAG-X1-C1qA-X2-C1qB-X3-C1qC-X4), comprising a fragment of SEQ ID NO: 01 (C1qA), a fragment of SEQ ID NO: 03 (C1qB), a fragment of SEQ ID NO: 05 (C1qC) and optionally a tag (TAG).
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公开(公告)号：US20220306761A1
公开(公告)日：2022-09-29
申请号：US17664609
申请日：2022-05-23
Applicant: Hoffmann-La Roche Inc.
Inventor： Harald DUERR , Sebastian FENN , Ulrich GOEPFERT , Sabine IMHOF-JUNG , Christian KLEIN , Laurent LARIVIERE , Michael MOLHOJ , Joerg Thomas REGULA , Petra RUEGER , Wolfgang SCHAEFER
Abstract: Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US20200216554A1
公开(公告)日：2020-07-09
申请号：US16822972
申请日：2020-03-18
Applicant: Hoffmann-La Roche Inc.
Inventor： Harald DUERR , Sebastian FENN , Ulrich GOEPFERT , Sabine IMHOF-JUNG , Christian KLEIN , Laurent LARIVIERE , Michael MOLHOJ , Joerg Thomas REGULA , Petra RUEGER , Wolfgang SCHAEFER
Abstract: Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.
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