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公开(公告)号：US20240317879A1
公开(公告)日：2024-09-26
申请号：US18732998
申请日：2024-06-04
Applicant: Hoffmann-La Roche Inc.
Inventor： Harald DUERR , Sebastian FENN , Ulrich GOEPFERT , Sabine IMHOF-JUNG , Christian KLEIN , Laurent LARIVIERE , Michael MOLHOJ , Joerg Thomas REGULA , Petra RUEGER , Wolfgang SCHAEFER
CPC classification number: C07K16/2887 , A61P25/00 , C07K16/2881 , C07K2317/31 , C07K2317/515 , C07K2317/522 , C07K2317/55 , C07K2317/66 , C07K2317/92 , C07K2317/94
Abstract: Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US20240117049A1
公开(公告)日：2024-04-11
申请号：US18457729
申请日：2023-08-29
Applicant: Hoffmann-La Roche Inc.
Inventor： Maria AMANN , Juergen Peter BACHL , Alexander BUJOTZEK , Carina CANTRILL , Harald DUERR , Janine FAIGLE , Sabine IMHOF-JUNG , Christian KLEIN , Thomas KRAFT , Estelle MARRER-BERGER , Ekkehard MOESSNER , Laurene POUSSE , Petra RUEGER , Johannes SAM , Roland STAACK , Dietrich TUERCK , Pablo UMANA , Joerg ZIELONKA
CPC classification number: C07K16/2809 , A61K45/06 , A61P35/00 , C07K16/2878 , C07K16/30 , C07K16/468 , C12N15/63 , A61K2039/505
Abstract: The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.
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公开(公告)号：US20210324108A1
公开(公告)日：2021-10-21
申请号：US16760820
申请日：2018-10-31
Applicant: Hoffmann-La Roche Inc.
Inventor： Maria AMANN , Claudia FERRARA KOLLER , Reto FLURY , Guy GEORGES , Sandra GRAU-RICHARDS , Alexander HAAS , Friederike HESSE , Sabine IMHOF-JUNG , Christian KLEIN
Abstract: The invention relates to novel bispecific antibodies consisting of two fusion polypeptides comprising two antigen binding domains capable of specific binding to a first target and one antigen binding domain capable of specific binding to a second target, and to methods of producing these molecules and to methods of using the same.
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公开(公告)号：US20210309730A1
公开(公告)日：2021-10-07
申请号：US17105181
申请日：2020-11-25
Applicant: Hoffmann-La Roche Inc.
Inventor： Wolfgang SCHAEFER , Christian KLEIN , Sabine IMHOF-JUNG , Stefan KLOSTERMANN , Michael MOLHOJ , Joerg Thomas REGULA
Abstract: The present invention relates to multispecific antibodies, their manufacture and use.
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公开(公告)号：US20250051429A1
公开(公告)日：2025-02-13
申请号：US18797664
申请日：2024-08-08
Applicant: Hoffmann-La Roche Inc.
Inventor： Per-Ola FRESKGARD , Guy GEORGES , Sabine IMHOF-JUNG , Markus NEUBAUER , Jens NIEWOEHNER , Petra RUEGER
Abstract: Herein is reported an antibody that binds to human A-beta protein, wherein the antibody comprises a heavy chain variable domain (VH) and a light chain variable domain comprising CDRs selected from (1) CDRs of SEQ ID NO: 85, 86, 87, 81, 82 and 83; or (2) CDRs of SEQ ID NO: 85, 89, 87, 81, 82 and 83; or (3) CDRs of SEQ ID NO: 85, 86, 87, 81, 82 and 91; or (4) CDRs of SEQ ID NO: 85, 89, 87, 81, 82 and 91.
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Patent Agency Ranking
公开(公告)号：US20230227584A1
公开(公告)日：2023-07-20
申请号：US17937440
申请日：2022-09-30
Applicant: Hoffmann-La Roche Inc.
Inventor： Maria AMANN , Ali BRANSI , Peter BRUENKER , Janine FAIGLE , Sabine IMHOF-JUNG , Roland STAACK , Joerg ZIELONKA
CPC classification number: C07K16/468 , C12N15/63 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/522
Abstract: The present invention relates to bispecific antibodies comprising a modified C-terminal crossfab fragment that have reduced or no reactivity against preexisting antidrug antibodies.
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公开(公告)号：US20220363771A1
公开(公告)日：2022-11-17
申请号：US17586455
申请日：2022-01-27
Applicant: Hoffmann-La Roche Inc.
Inventor： Joerg Thomas REGULA , Wolfgang SCHAEFER , Michael MOLHOJ , Sabine IMHOF-JUNG , Christian KLEIN
Abstract: The present invention relates to multispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies and uses thereof.
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公开(公告)号：US20220267463A1
公开(公告)日：2022-08-25
申请号：US17625719
申请日：2020-07-10
Applicant: Hoffmann-La Roche Inc.
Inventor： Pablo UMANA , Sabine IMHOF-JUNG , Alexander HAAS , Christian KLEIN , Sofia FROST , Felix BORMANN , Guy GEORGES , Sebastian FENN , Florian LIPSMEIER , Daniela MATSCHEKO , Joerg MOELLEKEN , Barbara WEISER
Abstract: The present invention relates to antibodies which bind to antigens on target cells and which target radionuclides to said cells, and to methods of using the same.
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公开(公告)号：US20200347147A1
公开(公告)日：2020-11-05
申请号：US16937536
申请日：2020-07-23
Applicant: Hoffmann-La Roche Inc.
Inventor： Marina BACAC , Tanja FAUTI , Sabine IMHOF-JUNG , Christian KLEIN , Stefan KLOSTERMANN , Ekkehard MOESSNER , Michael MOLHOJ , Christiane NEUMANN , Joerg Thomas REGULA , Wolfgang SCHAEFER , Pablo UMANA
Abstract: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号：US20240082437A1
公开(公告)日：2024-03-14
申请号：US18271835
申请日：2022-01-10
Applicant: Hoffmann-La Roche Inc.
Inventor： Christian KLEIN , Alexander HAAS , Sabine IMHOF-JUNG , Sofia FROST
CPC classification number: A61K51/1048 , A61P35/00 , C07K16/3007
Abstract: The present invention relates to antibodies which bind to antigens on target cells and which target effector moieties to said cells, and to methods of using the same.
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