公开(公告)号：US5415695A

公开(公告)日：1995-05-16

申请号：US175184

申请日：1993-12-29

申请人： Hendrikus W. Weterings ,  Hendrik Pluim

发明人： Hendrikus W. Weterings ,  Hendrik Pluim

IPC分类号： C07H3/04 ,  A61K31/70 ,  C07H1/06 ,  C13K13/00 ,  C13F1/02 ,  C07H1/00 ,  C08B37/00 ,  C13F3/00

CPC分类号： C13K13/005 ,  A61K31/70

摘要： The invention relates to a method of preparing solid forms of administration of lactulose by evaporating lactulose syrup to a water content of at most 10%, preferably 2 to 6%, cooling the thick, evaporated syrup, grinding and sieving, or breaking the solid product.

摘要翻译： 本发明涉及通过将乳果糖糖浆蒸发至至多10％，优选2-6％的水含量来制备乳果糖的固体形式的施用方法，冷却浓稠蒸发的糖浆，研磨和筛分，或破碎固体产物 。

公开(公告)号：US5026430A

公开(公告)日：1991-06-25

申请号：US566314

申请日：1990-08-13

申请人： Walterus T. de Haar ,  Hendrik Pluim

发明人： Walterus T. de Haar ,  Hendrik Pluim

IPC分类号： C07H3/04

CPC分类号： C07H3/04

摘要： The invention relates to a new method of preparing lactulose by basic isomerization of lactose. According to the invention the reaction mixture is treated with hydrogen peroxide or sodium chlorite to obtain lactulose of an acceptable color for a pharmaceutical product.Preferably 0.5-5 g of hydrogen peroxide are used per kg of lactose.1H.sub.2 O.

公开(公告)号：US5725749A

公开(公告)日：1998-03-10

申请号：US740398

申请日：1996-10-29

申请人： Hendrik Pluim

发明人： Hendrik Pluim

IPC分类号： C07H1/06 ,  A23C20060101 ,  B01D20060101 ,  B01D61/44 ,  B01D61/48 ,  C02F1/469 ,  C07B63/00 ,  C07H3/04 ,  C13D20060101 ,  C13K20060101 ,  C13K5/00 ,  C13K13/00

CPC分类号： B01D61/445 ,  C13K13/00 ,  C13K13/002

摘要： The invention relates to a process for the separation of lactulose from a mixture of lactulose and lactose in the presence of a weak acid capable of reversibly forming a complex with lactulose, by using an electrodialysis equipment including an anode and a cathode compartment separated by a plurality of parallel compartments comprising alternating diluate and concentrate compartments, wherein adjacent compartments are separated from each other by permselective membranes; which process is characterized by: (a) continuously passing an alkaline aqueous solution of lactulose, lactose and said complex forming weak acid through the diluate compartments, each diluate compartment being bound by a bipolar membrane at its lateral side facing the cathode and at its opposite lateral side by an anion exchange membrane, separating said compartment from its adjacent concentrate compartment; (b) continuously passing a carrier fluid through the concentrate compartments, each concentrate compartment being bound at its lateral side facing the anode by a bipolar membrane and at its opposite lateral side by said anion exchange membrane; and (c) maintaining an electric potential between anode and cathode which transports complexed lactulose preferentially to lactose from said diluate compartments to said concentrate compartments, in order to enrich the carrier fluid with complexed lactulose. The invention further relates to an electrodialysis equipment for use in the above process.

摘要翻译： 本发明涉及通过使用包括由多个分离的阳极和阴极室的电渗析设备，在能够可逆地与乳果糖形成复合物的弱酸存在下，从乳果糖和乳糖的混合物中分离乳果糖的方法 平行隔室包括交替的稀释区和浓缩室，其中相邻隔室通过选择性选择膜彼此分开; 该方法的特征在于：（a）将乳果糖，乳糖和形成弱酸的所述络合物的碱性水溶液连续通过稀释室，每个稀释隔室在其面向阴极的侧面与双极膜结合，并且在其相对的 侧面由阴离子交换膜，将所述隔室与其相邻的浓缩物室隔开; （b）使载体流体连续地通过浓缩物室，每个浓缩物隔室在其横向面上通过双极性膜结合在其阳离子的侧面，并在其相对的侧面由所述阴离子交换膜结合; 和（c）保持阳极和阴极之间的电位，其将络合的乳果糖优先地从所述稀释室到所述浓缩物室输送到乳糖，以便用络合的乳果糖富集载体流体。 本发明还涉及用于上述方法的电渗析设备。